(Q43268650)

English

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potentia

scientific article published in February 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potentia (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

drug interaction

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drug metabolism

1 reference

based on heuristic

inferred from title

Peter I Mackenzie

object named as

Peter I Mackenzie

2

0 references

author name string

John O Miners

1

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

Kathleen M Knights

3

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

language of work or name

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publication date

1 February 2010

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Europe PubMed Central

PubMed publication ID

17 November 2017

Drug Metabolism Reviews

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Europe PubMed Central

PubMed publication ID

17 November 2017

42

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

196-208

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants

1 reference

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21 January 2018

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

In vitro-in vivo correlations for drugs eliminated by glucuronidation: investigations with the model substrate zidovudine

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

The glucuronidation of Delta4-3-Keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Relative importance of intestinal and hepatic glucuronidation-impact on the prediction of drug clearance

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Altered AZT (3'-azido-3'-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil).

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Pharmacogenomics of human UDP-glucuronosyltransferase enzymes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

In vitro and in vivo glucuronidation of midazolam in humans

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase 1A10.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Metabolism of 26,26,26,27,27,27-F6-1 alpha,23S,25-trihydroxyvitamin D3 by human UDP-glucuronosyltransferase 1A3.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Sulfinpyrazone C-glucuronidation is catalyzed selectively by human UDP-glucuronosyltransferase 1A9.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

UDP-glucuronosyltransferases and clinical drug-drug interactions

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivation.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Glucuronidation of olanzapine by cDNA-expressed human UDP-glucuronosyltransferases and human liver microsomes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Nonspecific binding of drugs to human liver microsomes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Drug glucuronidation in humans

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

In vitro metabolism study of buprenorphine: evidence for new metabolic pathways.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

In vitro approaches to investigate mechanism-based inactivation of CYP enzymes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Structural and functional studies of UDP-glucuronosyltransferases

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

The "albumin effect" and in vitro-in vivo extrapolation: sequestration of long-chain unsaturated fatty acids enhances phenytoin hydroxylation by human liver microsomal and recombinant cytochrome P450 2C9.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Characterization of the binding of drugs to human intestinal fatty acid binding protein (IFABP): potential role of IFABP as an alternative to albumin for in vitro-in vivo extrapolation of drug kinetic parameters.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

The importance of local chemical structure for chemical metabolism by human uridine 5'-diphosphate-glucuronosyltransferase.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by udp-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates.

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kine

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomes

1 reference

https://api.crossref.org/works/10.3109%2F03602530903210716

21 January 2018

Identifiers

10.3109/03602530903210716

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 November 2017

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