(Q43752239)

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Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice

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26 November 2017

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice (English)

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Europe PubMed Central

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26 November 2017

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Nicolas Casadei

1

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26 November 2017

12

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26 November 2017

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Silke Nuber

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Olaf Riess

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26 November 2017

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Rejko Krüger

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26 November 2017

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Anne-Maria Pöhler

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26 November 2017

Cristina Tomás-Zapico

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26 November 2017

Jesús Torres-Peraza

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26 November 2017

Ivo Schwedhelm

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26 November 2017

Annemarie Witz

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26 November 2017

Irina Zamolo

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26 November 2017

Raymond De Heer

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26 November 2017

Berry Spruijt

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26 November 2017

Lucas P J J Noldus

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26 November 2017

Jochen Klucken

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26 November 2017

Philipp J Kahle

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26 November 2017

publication date

24 September 2013

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26 November 2017

Human Molecular Genetics

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26 November 2017

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3

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26 November 2017

767-781

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26 November 2017

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Lewy pathology and neurodegeneration in premotor Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Staging of brain pathology related to sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

The many faces of α-synuclein: from structure and toxicity to therapeutic target

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

In vivo demonstration that alpha-synuclein oligomers are toxic

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

α-Synuclein oligomers and clinical implications for Parkinson disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Structural and functional implications of C-terminal regions of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Ubiquitination of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Protein degradation, aggregation, and misfolding

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

α-Synuclein and protein degradation systems: a reciprocal relationship

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Protein degradation pathways in Parkinson's disease: curse or blessing

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Molecular determinants of selective clearance of protein inclusions by autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Impaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Aggresomes, inclusion bodies and protein aggregation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Monitoring autophagic degradation of p62/SQSTM1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

The Beclin 1 network regulates autophagy and apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Lysosomal degradation of alpha-synuclein in vivo.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

A role for ubiquitin in selective autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Endoproteolytic activity of the proteasome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Hassles with taking out the garbage: aggravating aggresomes.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Lipid rafts mediate the synaptic localization of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

The use of behavioral test batteries: effects of training history.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Gait dynamics in mouse models of Parkinson's disease and Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

NIH Image to ImageJ: 25 years of image analysis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT467

21 January 2018

Identifiers

10.1093/HMG/DDT467

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

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https://api.fatcat.wiki/v0/release/oaskvlrqjja4bp4ddwa3s7noze

24 November 2022

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Europe PubMed Central

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26 November 2017

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