(Q44505963)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12850145%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

ZZ made EZ: influence of inhibitor configuration on enzyme selectivity (English)

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5 November 2019

1

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5 November 2019

Milton T Stubbs

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12850145%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

3

Jörg Stürzebecher

1 reference

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5 November 2019

author name string

Gerhard Klebe

series ordinal

2

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5 November 2019

language of work or name

English

0 references

publication date

1 July 2003

1 reference

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Journal of Molecular Biology

5 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12850145%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

volume

330

1 reference

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5 November 2019

issue

4

1 reference

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5 November 2019

page(s)

761-770

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12850145%20AND%20SRC:MED&resulttype=core&format=json

Synthetic inhibitors of thrombin and factor Xa: from bench to bedside

5 November 2019

cites work

1 reference

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Bioactive diversity and screening library selection via affinity fingerprinting

7 January 2021

1 reference

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Three-dimensional quantitative structure-activity relationship analyses using comparative molecular field analysis and comparative molecular similarity indices analysis to elucidate selectivity differences of inhibitors binding to trypsin, thrombin,

7 January 2021

1 reference

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Protease inhibitors: current status and future prospects

7 January 2021

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Strategies for the inhibition of serine proteases

7 January 2021

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Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

7 January 2021

1 reference

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pH-dependent binding modes observed in trypsin crystals: lessons for structure-based drug design

7 January 2021

1 reference

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Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.

7 January 2021

1 reference

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Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity

7 January 2021

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Trypsin mutants for structure-based drug design: expression, refolding and crystallisation.

7 January 2021

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Synthetic inhibitors of bovine factor Xa and thrombin comparison of their anticoagulant efficiency

7 January 2021

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Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

7 January 2021

1 reference

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(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.

7 January 2021

1 reference

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Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enz

7 January 2021

1 reference

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Design of benzamidine-type inhibitors of factor Xa

7 January 2021

1 reference

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X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

7 January 2021

1 reference

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(R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups

7 January 2021

1 reference

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Crystal structures of human factor Xa complexed with potent inhibitors

7 January 2021

1 reference

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Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Structural basis for chemical inhibition of human blood coagulation factor Xa

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Design, synthesis, and in vitro biological activity of benzimidazole based factor Xa inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Structure-based screening of low-affinity compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Discovering novel ligands for macromolecules using X-ray crystallographic screening

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Approaches to the description and prediction of the binding affinity of small-molecule ligands to macromolecular receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases

7 January 2021

1 reference

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The graphical determination of Km and Ki

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Processing of X-ray diffraction data collected in oscillation mode

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

Improved methods for building protein models in electron density maps and the location of errors in these models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900617-X

10.1016/S0022-2836(03)00617-X

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12850145%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference