(Q44555224)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927549%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

GTPase catalysis by Ras and other G-proteins: insights from Substrate Directed SuperImposition (English)

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7 November 2019

1

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7 November 2019

author name string

Zvi Selinger

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927549%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

language of work or name

English

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publication date

1 August 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927549%20AND%20SRC:MED&resulttype=core&format=json

Journal of Molecular Biology

7 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927549%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

331

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927549%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

issue

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927549%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

page(s)

1157-1170

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927549%20AND%20SRC:MED&resulttype=core&format=json

G protein mechanisms: insights from structural analysis

7 November 2019

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Substrate assisted catalysis -- application to G proteins.

7 January 2021

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G proteins, effectors and GAPs: structure and mechanism

7 January 2021

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GTPase-activating proteins: helping hands to complement an active site

7 January 2021

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GTPase-activating proteins and their complexes.

7 January 2021

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The many faces of Ras: recognition of small GTP-binding proteins

7 January 2021

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The guanine nucleotide-binding switch in three dimensions

7 January 2021

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Signaling mechanistics: aluminum fluoride for molecule of the year

7 January 2021

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A study into the effects of protein binding on nucleotide conformation

7 January 2021

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Protein recognition of adenylate: an example of a fuzzy recognition template

7 January 2021

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A method to search for similar protein local structures at ligand binding sites and its application to adenine recognition

7 January 2021

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Structural motif of phosphate-binding site common to various protein superfamilies: all-against-all structural comparison of protein-mononucleotide complexes

7 January 2021

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Conserved positions for ribose recognition: importance of water bridging interactions among ATP, ADP and FAD-protein complexes

7 January 2021

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Lectin-carbohydrate interactions: different folds, common recognition principles

7 January 2021

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An approach for visualization of the active site of enzymes with unknown three-dimensional structures

7 January 2021

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On the molecular discrimination between adenine and guanine by proteins

7 January 2021

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Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1

7 January 2021

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How the Pseudomonas aeruginosa ExoS toxin downregulates Rac

7 January 2021

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Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

7 January 2021

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Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

7 January 2021

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Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

7 January 2021

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The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins

7 January 2021

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Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

7 January 2021

1 reference

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Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

7 January 2021

1 reference

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Molecular dynamics simulation of the solution structures of Ha-ras-p21 GDP and GTP complexes: flexibility, possible hinges, and levers of the conformational transition.

7 January 2021

1 reference

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Ligand-induced conformational changes in ras p21: a normal mode and energy minimization analysis.

7 January 2021

1 reference

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Structural changes induced in p21Ras upon GAP-334 complexation as probed by ESEEM spectroscopy and molecular-dynamics simulation

7 January 2021

1 reference

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Mechanical force generation by G proteins

7 January 2021

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Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue

7 January 2021

1 reference

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Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin.

7 January 2021

1 reference

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

7 January 2021

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Biological and biochemical properties of human rasH genes mutated at codon 61.

7 January 2021

1 reference

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Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

7 January 2021

1 reference

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Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1

7 January 2021

1 reference

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Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product

7 January 2021

1 reference

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Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

7 January 2021

1 reference

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X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis

7 January 2021

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Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism

7 January 2021

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Guanosine triphosphatase stimulation of oncogenic Ras mutants

7 January 2021

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Raman difference studies of GDP and GTP binding to c-Harvey ras.

7 January 2021

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Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate

7 January 2021

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The mechanism of GTP hydrolysis by Ras probed by Fourier transform infrared spectroscopy

7 January 2021

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Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time

7 January 2021

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Ras catalyzes GTP hydrolysis by shifting negative charges from gamma- to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy

7 January 2021

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Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21.

7 January 2021

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Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative

7 January 2021

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Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity

7 January 2021

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The P-loop--a common motif in ATP- and GTP-binding proteins

7 January 2021

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Phosphoryl transfer by a concerted reaction mechanism in UMP/CMP-kinase

7 January 2021

1 reference

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Movie of the structural changes during a catalytic cycle of nucleoside monophosphate kinases

7 January 2021

1 reference

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Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

7 January 2021

1 reference

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How does GAP catalyze the GTPase reaction of Ras? A computer simulation study

7 January 2021

1 reference

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Enzyme dynamics during catalysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900847-7

Impact of enzyme motion on activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900847-7

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900847-7

The conserved arginine in rho-GTPase-activating protein is essential for efficient catalysis but not for complex formation with Rho.GDP and aluminum fluoride

7 January 2021

1 reference

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Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

7 January 2021

1 reference

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Why have mutagenesis studies not located the general base in ras p21.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900847-7

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900847-7

Mechanistic analysis of the observed linear free energy relationships in p21ras and related systems.

7 January 2021

1 reference

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Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.

7 January 2021

1 reference

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Vibrational structure of GDP and GTP bound to RAS: an isotope-edited FTIR study

7 January 2021

1 reference

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Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites

7 January 2021

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Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

7 January 2021

1 reference

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GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

7 January 2021

1 reference

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Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

7 January 2021

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Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant

7 January 2021

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The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1

7 January 2021

1 reference

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The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

7 January 2021

1 reference

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The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900847-7

Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex

7 January 2021

1 reference

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pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog

7 January 2021

1 reference

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10.1016/S0022-2836(03)00847-7

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927549%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference