(Q44559365)

English

Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt

scientific article published on 20 August 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 December 2017

Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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1 reference

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object named as

Meriem Hasmim

2

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Olivier Dormond

object named as

Olivier Dormond

4

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author name string

Manuela Bezzi

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Grégory Bieler

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Curzio Rüegg

5

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Europe PubMed Central

PubMed publication ID

4 December 2017

language of work or name

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publication date

20 August 2003

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Europe PubMed Central

PubMed publication ID

4 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

4 December 2017

278

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Europe PubMed Central

PubMed publication ID

4 December 2017

44

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

43603-43614

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Overview of bisphosphonates

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Developments in the therapeutic applications of bisphosphonates

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Bisphosphonates in cancer therapy

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Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

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Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

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21 January 2018

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.

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The anti-tumour activity of bisphosphonates.

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Antitumor effects of bisphosphonates

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Angiogenesis in cancer and other diseases

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Angiogenesis in health and disease

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Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid

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Bone resorption by osteoclasts

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Integrins and cancer

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Vascular integrins: pleiotropic adhesion and signaling molecules in vascular homeostasis and angiogenesis.

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Integrins: versatility, modulation, and signaling in cell adhesion

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Osteoclasts, integrins, and osteoporosis.

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alpha(v)beta(3) Integrin antagonists as inhibitors of bone resorption

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NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.

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Pulse treatment of human vascular endothelial cells with high doses of tumor necrosis factor and interferon-gamma results in simultaneous synergistic and reversible effects on proliferation and morphology

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Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro

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EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion

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21 January 2018

Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain

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21 January 2018

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

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Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again

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Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement

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21 January 2018

Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation

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21 January 2018

Focal adhesion kinase affects the sensitivity of human hepatocellular carcinoma cell line SMMC-7721 to tumor necrosis factor-alpha/cycloheximide-induced apoptosis by regulating protein kinase B levels

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21 January 2018

Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cells

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21 January 2018

DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon-gamma

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21 January 2018

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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21 January 2018

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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21 January 2018

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

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Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts.

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21 January 2018

The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation

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21 January 2018

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

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21 January 2018

Inhibition of phosphatidylinositol-3 kinase/Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-alpha cytotoxicity

1 reference

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A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

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21 January 2018

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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Four deaths and a funeral: from caspases to alternative mechanisms.

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Bisphosphonates induce breast cancer cell death in vitro

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The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro.

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Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

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Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro

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BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

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Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

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Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility

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Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

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Insulin-induced tyrosine dephosphorylation of paxillin and focal adhesion kinase requires active phosphotyrosine phosphatase 1D.

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21 January 2018

The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin.

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21 January 2018

Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase

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21 January 2018

A decision between life and death during TNF-alpha-induced signaling

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NF-kappaB signals induce the expression of c-FLIP.

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21 January 2018

Biochemical signals and biological responses elicited by the focal adhesion kinase

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21 January 2018

Ten years of protein kinase B signalling: a hard Akt to follow

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Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

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The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells

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Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells

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The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel

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The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate

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ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

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Therapeutic applications of vacuum biopsy

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Mechanisms of action of bisphosphonates

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Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes

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Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

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Integrin affinity modulation

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Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma

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Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone

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Decreased tyrosine phosphorylation of focal adhesion kinase after estradiol treatment of MCF-7 human breast carcinoma cells

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Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity

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Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells

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Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells

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Clinical applications of TNF-alpha in cancer

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Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines

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Identifiers

10.1074/JBC.M308114200

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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