(Q45716125)

15 December 2017

title

A systematic investigation of iminosugar click clusters as pharmacological chaperones for the treatment of Gaucher disease (English)

1 reference

15 December 2017

0 references

1 reference

1 reference

Antoine Joosten

1

1 reference

15 December 2017

Camille Decroocq

2

1 reference

15 December 2017

Julien de Sousa

3

1 reference

15 December 2017

Jérémy P Schneider

4

1 reference

15 December 2017

Emile Etamé

5

1 reference

15 December 2017

Anne Bodlenner

6

1 reference

15 December 2017

Terry D Butters

7

1 reference

15 December 2017

Philippe Compain

8

1 reference

15 December 2017

publication date

20 December 2013

1 reference

15 December 2017

1 reference

15 December 2017

volume

15

1 reference

15 December 2017

issue

2

1 reference

15 December 2017

page(s)

309-319

1 reference

Chemical chaperones--a new concept in drug research

15 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

What are pharmacological chaperones and why are they interesting?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Molecular chaperones as therapeutic targets to counteract proteostasis defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

A contradictory treatment for lysosomal storage disorders: inhibitors enhance mutant enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Pharmacologic chaperoning as a strategy to treat Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Enzyme replacement and enhancement therapies for lysosomal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Emerging drugs for lysosomal storage diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Identification and characterization of pharmacological chaperones to correct enzyme deficiencies in lysosomal storage disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Pharmacological chaperone therapy for Gaucher disease: a patent review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Pharmacological chaperones as therapeutics for lysosomal storage diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Glucocerebrosidase inhibitors for the treatment of Gaucher disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

The molecular basis of lysosomal storage diseases and their treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Protein misfolding disorders: pathogenesis and intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Lysosomal storage diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Sphingolipid metabolism diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Glycosphingolipidoses: beyond the enzymatic defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Glycosphingolipids--nature, function, and pharmacological modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Pharmacological small molecules for the treatment of lysosomal storage disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Limitations of enzyme replacement therapy: current and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Enzyme replacement therapy for lysosomal diseases: lessons from 20 years of experience and remaining challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Therapeutic applications of imino sugars in lysosomal storage disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Substrate reduction therapy for glycosphingolipid storage disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Substrate reduction therapy in mouse models of the glycosphingolipidoses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Substrate reduction therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Treatment options for lysosomal storage disorders: developing insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

New directions in the treatment of Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Gaucher disease: unmet treatment needs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Miglustat as a therapeutic agent: prospects and caveats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Isofagomine induced stabilization of glucocerebrosidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Impaired trafficking of mutants of lysosomal glucocerebrosidase in Gaucher's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

One step at a time: endoplasmic reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Gaucher disease paradigm: from ERAD to comorbidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

X-ray and biochemical analysis of N370S mutant human acid β-glucosidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Pharmacological chaperones facilitate the post-ER transport of recombinant N370S mutant β-glucocerebrosidase in plant cells: evidence that N370S is a folding mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Iminosugars past, present and future: medicines for tomorrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Correlation between enzyme activity and substrate storage in a cell culture model system for Gaucher disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Ex vivo and in vivo effects of isofagomine on acid β-glucosidase variants and substrate levels in Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Glycosidase inhibition with fullerene iminosugar balls: a dramatic multivalent effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

The multivalent effect in glycosidase inhibition: probing the influence of valency, peripheral ligand structure, and topology with cyclodextrin-based iminosugar click clusters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Cu-catalyzed azide-alkyne cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Diverse motifs of mannoside clustering on a beta-cyclodextrin core

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Multivalency in supramolecular chemistry and nanofabrication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300442

21 January 2018

Identifiers

DOI

10.1002/CBIC.201300442

1 reference

15 December 2017

1 reference