(Q46019370)

18 December 2017

title

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models. (English)

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18 December 2017

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Yadong Huang

1

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18 December 2017

publication date

1 August 2011

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18 December 2017

Biochemical Society Transactions

published in

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18 December 2017

volume

39

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18 December 2017

issue

4

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18 December 2017

page(s)

924-932

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18 December 2017

The molecular pathology of Alzheimer's disease

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Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E

21 January 2018

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Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

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Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

21 January 2018

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Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue

21 January 2018

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Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

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Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner.

21 January 2018

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

21 January 2018

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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

21 January 2018

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Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

21 January 2018

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Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function

21 January 2018

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Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice

21 January 2018

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Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.

21 January 2018

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Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

21 January 2018

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Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice.

21 January 2018

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Specific regional transcription of apolipoprotein E in human brain neurons

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390924

Regionally specific neuronal expression of human APOE gene in transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390924

Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390924

Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction.

21 January 2018

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Synthesis and processing of apolipoprotein E in human brain cultures

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390924

ApoE synthesis in human neuroblastoma cells.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390924

Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390924

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

21 January 2018

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Apolipoprotein E and cognitive performance

21 January 2018

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Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond

21 January 2018

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Apolipoprotein E, a gene with complex biological interactions in the aging brain

21 January 2018

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Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease

21 January 2018

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Clearing the brain's amyloid cobwebs

21 January 2018

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

21 January 2018

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Truncated apoE forms tangle-like structures in a neuronal cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Cellular uptake of the tat protein from human immunodeficiency virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Structural and functional variations in human apolipoprotein E3 and E4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Use of cytoplasmic hybrid cell lines for elucidating the role of mitochondrial dysfunction in Alzheimer's disease and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Differentiated Alzheimer's disease transmitochondrial cybrid cell lines exhibit reduced organelle movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Deficiency in Mitochondrial Aldehyde Dehydrogenase Increases the Risk for Late-Onset Alzheimer's Disease in the Japanese Population

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Cerebral glucose metabolism in patients with AD and different APOE genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

The role of apolipoprotein E in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Oxidative protein damage in cells engaged in beta-amyloidosis is related to apoE genotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Apolipoprotein E receptors: linking brain development and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Multiple pathways of apolipoprotein E signaling in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST0390924

21 January 2018

Identifiers

DOI

10.1042/BST0390924

1 reference

18 December 2017

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18 December 2017