(Q46802974)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

title

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity (English)

1 reference

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1 January 2020

1 reference

10

1 reference

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1 January 2020

Joseph A. Trapani

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Jane Oliaro

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

John Silke

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Olivia Susanto

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Douglas R. Green

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Phillip I. Bird

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

author name string

K A Sedelies

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

A Ciccone

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

C J P Clarke

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

V R Sutton

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

F L Scott

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

N J Waterhouse

13

1 reference

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1 January 2020

publication date

18 January 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18202705%20AND%20SRC:MED&resulttype=core&format=json

Cell Death & Differentiation

1 January 2020

published in

1 reference

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1 January 2020

volume

15

1 reference

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1 January 2020

issue

4

1 reference

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1 January 2020

page(s)

708-717

1 reference

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Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

1 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Disruption of Mcl-1.Bim complex in granzyme B-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Use of protease proteomics to discover granzyme B substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition

21 January 2018

1 reference

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Caspase activation: the induced-proximity model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Human and murine granzyme B exhibit divergent substrate preferences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

The major human and mouse granzymes are structurally and functionally divergent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

A central role for Bid in granzyme B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis

21 January 2018

1 reference

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Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Non-specific effects of methyl ketone peptide inhibitors of caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Calpain activation is upstream of caspases in radiation-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

Expression and purification of recombinant human granzyme B from Pichia pastoris

21 January 2018

1 reference

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A new quantitative assay for cytochrome c release in apoptotic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

7 January 2021

Lymphomas are sensitive to perforin-dependent cytotoxic pathways despite expression of PI-9 and overexpression of bcl-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

7 January 2021

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

7 January 2021

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402300

7 January 2021