(Q47111476)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

title

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Roberto Piñeiro

2

1 reference

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4 April 2020

Nicholas McGranahan

5

1 reference

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4 April 2020

Nicolai Juul Birkbak

8

1 reference

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4 April 2020

Shankar Srinivas

13

1 reference

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4 April 2020

Mariona Graupera

14

1 reference

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4 April 2020

Cheryl Scudamore

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

Charles Swanton

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

6

Sally M Dewhurst

1 reference

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4 April 2020

12

Nnennaya Kanu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

10

Laurent Sansregret

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

23

Bart Vanhaesebroeck

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

author name string

Inma M Berenjeno

1

1 reference

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4 April 2020

Sandra D Castillo

3

1 reference

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4 April 2020

Wayne Pearce

4

1 reference

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4 April 2020

Valerie Meniel

7

1 reference

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4 April 2020

Evelyn Lau

9

1 reference

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4 April 2020

Daniele Morelli

11

1 reference

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4 April 2020

Victoria E R Parker

15

1 reference

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4 April 2020

Karen G Montgomery

16

1 reference

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4 April 2020

Larissa S Moniz

17

1 reference

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4 April 2020

Robert K Semple

20

1 reference

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4 April 2020

Alan Clarke

21

1 reference

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4 April 2020

language of work or name

English

0 references

publication date

24 November 2017

1 reference

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4 April 2020

published in

Nature Communications

1 reference

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4 April 2020

volume

8

1 reference

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4 April 2020

issue

1

1 reference

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4 April 2020

page(s)

1773

1 reference

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Creative Commons Attribution 4.0 International

4 April 2020

copyright license

start time

24 November 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/s41467-017-02002-4

0 references

cites work

Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals

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Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate

23 May 2018

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Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy

23 May 2018

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Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival

23 May 2018

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Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.

23 May 2018

1 reference

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Molecules in medicine mini-review: isoforms of PI3K in biology and disease

23 May 2018

1 reference

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Centrosomes and cancer: revisiting a long-standing relationship

23 May 2018

1 reference

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Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.

23 May 2018

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Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

23 May 2018

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PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting

23 May 2018

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Cytokinesis failure triggers hippo tumor suppressor pathway activation.

23 May 2018

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Causes and consequences of centrosome abnormalities in cancer

23 May 2018

1 reference

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Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

23 May 2018

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PI3K and cancer: lessons, challenges and opportunities

23 May 2018

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Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

23 May 2018

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Pan-cancer patterns of somatic copy number alteration

23 May 2018

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Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors.

23 May 2018

1 reference

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Centrosomes, chromosome instability (CIN) and aneuploidy

23 May 2018

1 reference

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Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

23 May 2018

1 reference

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Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

23 May 2018

1 reference

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Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors

23 May 2018

1 reference

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Absolute quantification of somatic DNA alterations in human cancer

23 May 2018

1 reference

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Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

23 May 2018

p53: guardian of ploidy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

The causes and consequences of polyploidy in normal development and cancer

23 May 2018

1 reference

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A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts

23 May 2018

1 reference

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Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification.

23 May 2018

1 reference

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Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

23 May 2018

1 reference

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A mechanism linking extra centrosomes to chromosomal instability

23 May 2018

1 reference

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

23 May 2018

1 reference

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Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

23 May 2018

1 reference

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Oncogenes and tumour suppressors take on centrosomes

23 May 2018

1 reference

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Tetraploidy, aneuploidy and cancer

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Centrosome control of the cell cycle

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Mutated PI 3-kinases: cancer targets on a silver platter.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

High frequency of mutations of the PIK3CA gene in human cancers

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Managing the centrosome numbers game: from chaos to stability in cancer cell division

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

The PI3K-Akt mediates oncogenic Met-induced centrosome amplification and chromosome instability

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Ligand-activated Flpe for temporally regulated gene modifications

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Transgenic mouse line with green-fluorescent protein-labeled Centrin 2 allows visualization of the centrosome in living cells

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5701070

Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

15 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-017-02002-4

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41467-017-02002-4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29170395%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

PubMed publication ID

29170395

1 reference