(Q47344527)

14 January 2018

review article

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title

Ribosome biogenesis in cancer: new players and therapeutic avenues (English)

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14 January 2018

Corrigendum: Ribosome biogenesis in cancer: new players and therapeutic avenues

corrigendum / erratum

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author name string

Joffrey Pelletier

series ordinal

1

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14 January 2018

George Thomas

series ordinal

2

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14 January 2018

Siniša Volarević

series ordinal

3

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14 January 2018

language of work or name

English

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publication date

1 December 2017

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14 January 2018

published in

Nature Reviews Cancer

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14 January 2018

volume

18

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14 January 2018

issue

1

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14 January 2018

page(s)

51-63

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14 January 2018

Evolution of protein synthesis from an RNA world

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Directed proteomic analysis of the human nucleolus

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Functional proteomic analysis of human nucleolus

21 January 2018

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Nucleolar proteome dynamics

21 January 2018

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Deciphering the human nucleolar proteome

21 January 2018

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Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide

21 January 2018

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Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning

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Translating the genome in time and space: specialized ribosomes, RNA regulons, and RNA-binding proteins

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RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation

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Functional specificity among ribosomal proteins regulates gene expression

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A new system for naming ribosomal proteins

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Ribosome-omics of the human ribosome

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The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1

21 January 2018

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Differential Stoichiometry among Core Ribosomal Proteins

21 January 2018

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The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity

21 January 2018

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Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system

21 January 2018

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Nucleolar localization of a netrin-1 isoform enhances tumor cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis.

21 January 2018

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

21 January 2018

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HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

21 January 2018

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Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state

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Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.

21 January 2018

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Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.

21 January 2018

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The role of human ribosomal proteins in the maturation of rRNA and ribosome production

21 January 2018

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Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits

21 January 2018

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Quality control mechanisms during ribosome maturation

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Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.

21 January 2018

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Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

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Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis

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Dysregulation of ribosome biogenesis and translational capacity is associated with tumor progression of human breast cancer cells.

21 January 2018

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p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.

21 January 2018

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p53, a translational regulator: contribution to its tumour-suppressor activity.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

Profiling of 2'-O-Me in human rRNA reveals a subset of fractionally modified positions and provides evidence for ribosome heterogeneity

21 January 2018

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The cancerous translation apparatus

21 January 2018

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Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita

21 January 2018

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rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells.

21 January 2018

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H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation.

21 January 2018

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In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes

21 January 2018

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Ribosomal RNA gene repeats, their stability and cellular senescence

21 January 2018

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21 January 2018

Chromosome fragile sites

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21 January 2018

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21 January 2018

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Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

21 January 2018

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21 January 2018

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R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters

21 January 2018

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R loops: from transcription byproducts to threats to genome stability

21 January 2018

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Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.

21 January 2018

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DNA double-strand break repair within heterochromatic regions

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Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks.

21 January 2018

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A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage.

21 January 2018

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Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

21 January 2018

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Discovery and saturation analysis of cancer genes across 21 tumour types

21 January 2018

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The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

21 January 2018

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ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

21 January 2018

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The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

21 January 2018

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Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response.

21 January 2018

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Epigenetic control of RNA polymerase I transcription in mammalian cells

21 January 2018

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Exploiting replicative stress to treat cancer

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Replication stress and cancer

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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

21 January 2018

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The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

21 January 2018

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Loss of Bloom syndrome protein destabilizes human gene cluster architecture

21 January 2018

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Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus

21 January 2018

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Epigenetic control of rDNA loci in response to intracellular energy status

21 January 2018

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Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability

21 January 2018

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The NAD+ synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1) regulates ribosomal RNA transcription

21 January 2018

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Nucleolar repression facilitates initiation and maintenance of senescence

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mTOR Signaling in Growth, Metabolism, and Disease.

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Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

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mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

21 January 2018

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mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

21 January 2018

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Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells

21 January 2018

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Cancer biology: The director's cut.

21 January 2018

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

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A unifying model for mTORC1-mediated regulation of mRNA translation.

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

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21 January 2018

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Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

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AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

21 January 2018

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mTORC1 and mTORC2 in cancer and the tumor microenvironment

21 January 2018

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Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

21 January 2018

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Targeting the translation machinery in cancer

21 January 2018

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Proteome complexity and the forces that drive proteome imbalance.

21 January 2018

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Ribosome-associated protein quality control

21 January 2018

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A dual function for chaperones SSB-RAC and the NAC nascent polypeptide-associated complex on ribosomes

21 January 2018

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Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival

21 January 2018

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Coordinated regulation of protein synthesis and degradation by mTORC1

21 January 2018

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Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

Regulation of HDM2 activity by the ribosomal protein L11

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

21 January 2018

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Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The multifunctional nucleolus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Post-translational modification of p53 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Signaling to p53: ribosomal proteins find their way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2017.104

Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation

21 January 2018

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Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

21 January 2018

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An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

21 January 2018

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c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells

21 January 2018

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Transcriptional amplification in tumor cells with elevated c-Myc.

21 January 2018

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Intrinsic tumour suppression

21 January 2018

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Inhibition of c-Myc activity by ribosomal protein L11

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Inside and out: the activities of senescence in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

An oncogene-induced DNA damage model for cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

p53 and ribosome biogenesis stress: the essentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Structural insights into G-quadruplexes: towards new anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Chemotherapeutic drugs inhibit ribosome biogenesis at various levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Comprehensive molecular characterization of human colon and rectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The consensus molecular subtypes of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Targeting the ubiquitin proteasome system in haematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Modulation of RNA polymerase assembly dynamics in transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Cell cycle-dependent regulation of RNA polymerase I transcription: the nucleolar transcription factor UBF is inactive in mitosis and early G1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Temporal order of replication of mouse ribosomal RNA genes during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The chromatin remodeling complex NoRC controls replication timing of rRNA genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Separation of replication and transcription domains in nucleoli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The Human RNA Polymerase I Transcription Terminator Complex Acts as a Replication Fork Barrier That Coordinates the Progress of Replication with rRNA Transcription Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The epigenetics of rRNA genes: from molecular to chromosome biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The DNA damage checkpoint response to replication stress: A Game of Forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

p53 Activity Results in DNA Replication Fork Processivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Version 4.0 of PaxDb: Protein abundance data, integrated across model organisms, tissues, and cell-lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Cotranscriptional events in eukaryotic ribosome synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The structure and function of the eukaryotic ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Regulation of mammalian nucleotide metabolism and biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

An overview of pre-ribosomal RNA processing in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Powering through ribosome assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Building ribosomes: even more expensive than expected?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Deep proteome and transcriptome mapping of a human cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The quantitative proteome of a human cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

In the absence of ribosomal RNA synthesis, the ribosomal proteins of HeLa Cells are synthesized normally and degraded rapidly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

A quantitative spatial proteomics analysis of proteome turnover in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The relationship between the nucleolus and cancer: Current evidence and emerging paradigms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Quantitation of Human Ribosomal DNA: Hybridization of Human DNA with Ribosomal RNA for Quantitation and Fractionation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Human rRNA gene clusters are recombinational hotspots in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Inhibition of RNA synthesis by actinomycin D: Characteristic dose-response of different RNA species

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2017.104

Cellular and molecular pharmacology of oxaliplatin.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29192214

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC.2017.104

1 reference

14 January 2018

Dimensions Publication ID

1093093024

0 references

1 reference

14 January 2018