(Q34473453)

2 August 2017

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title

Replication stress and cancer (English)

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2 August 2017

Tatiana García-Muse

2

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Hélène Gaillard

object named as

Hélène Gaillard

series ordinal

1

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Andrés Aguilera

object named as

Andrés Aguilera

series ordinal

3

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language of work or name

English

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publication date

1 May 2015

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2 August 2017

published in

Nature Reviews Cancer

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2 August 2017

volume

15

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2 August 2017

issue

5

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2 August 2017

page(s)

276-289

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https://scigraph.springernature.com/pub.10.1038/nrc3916

2 August 2017

exact match

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cites work

Oxidative DNA damage, antioxidants, and cancer

1 reference

The landscape of somatic copy-number alteration across human cancers

31 March 2020

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DNA replication and oncogene-induced replicative stress

31 March 2020

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

1 reference

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

1 reference

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

31 March 2020

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

31 March 2020

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Mutational landscape and significance across 12 major cancer types

31 March 2020

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Replication stress induces tumor-like microdeletions in FHIT/FRA3B

31 March 2020

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Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

31 March 2020

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Causes of genome instability

31 March 2020

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Activation of the replicative DNA helicase: breaking up is hard to do.

31 March 2020

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How dormant origins promote complete genome replication

31 March 2020

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ATR and ATM regulate the timing of DNA replication origin firing

31 March 2020

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

31 March 2020

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

31 March 2020

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ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

31 March 2020

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

31 March 2020

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Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

31 March 2020

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Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

31 March 2020

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Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells

31 March 2020

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Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer

31 March 2020

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An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

31 March 2020

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Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis.

31 March 2020

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Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.

31 March 2020

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Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

31 March 2020

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Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.

31 March 2020

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A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice.

31 March 2020

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Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

31 March 2020

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Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites

31 March 2020

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Deregulation of cyclin E in human cells interferes with prereplication complex assembly

31 March 2020

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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

31 March 2020

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Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.

31 March 2020

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A p53-dependent checkpoint pathway prevents rereplication

31 March 2020

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Loss of Geminin induces rereplication in the presence of functional p53

31 March 2020

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Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior

31 March 2020

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Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

31 March 2020

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The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells.

31 March 2020

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KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors

31 March 2020

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MYC and the control of DNA replication

31 March 2020

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Non-transcriptional control of DNA replication by c-Myc

31 March 2020

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Cdc45 is a critical effector of myc-dependent DNA replication stress.

31 March 2020

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The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing

31 March 2020

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Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

31 March 2020

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Nucleotide deficiency promotes genomic instability in early stages of cancer development

31 March 2020

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Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase

31 March 2020

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Checking on DNA damage in S phase

31 March 2020

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How the fanconi anemia pathway guards the genome

31 March 2020

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Transcription-associated genome instability

31 March 2020

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Transcription-associated recombination is dependent on replication in Mammalian cells

31 March 2020

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Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

31 March 2020

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Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates.

31 March 2020

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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

31 March 2020

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Genome instability and transcription elongation impairment in human cells depleted of THO/TREX

31 March 2020

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A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability

31 March 2020

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Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes

31 March 2020

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The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts

31 March 2020

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BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

31 March 2020

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c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells

31 March 2020

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Transcriptional amplification in tumor cells with elevated c-Myc.

31 March 2020

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Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.

31 March 2020

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DNA helicases involved in DNA repair and their roles in cancer

31 March 2020

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Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

31 March 2020

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RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures

31 March 2020

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RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress

31 March 2020

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Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

31 March 2020

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Role for BLM in replication-fork restart and suppression of origin firing after replicative stress

31 March 2020

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The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks

31 March 2020

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Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes

31 March 2020

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The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

31 March 2020

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FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

31 March 2020

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FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress

31 March 2020

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The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation

31 March 2020

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A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression.

31 March 2020

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Structural and functional relationships of the XPF/MUS81 family of proteins

31 March 2020

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

31 March 2020

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Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin

31 March 2020

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FANCD2 and CtIP cooperate to repair DNA interstrand crosslinks

31 March 2020

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Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.

31 March 2020

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BRCA1 is required for postreplication repair after UV-induced DNA damage

31 March 2020

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Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

31 March 2020

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Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

31 March 2020

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BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

31 March 2020

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Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

31 March 2020

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A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

31 March 2020

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FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling.

31 March 2020

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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

31 March 2020

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Involvement of Brca2 in DNA repair

31 March 2020

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Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

31 March 2020

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

31 March 2020

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Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

31 March 2020

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BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair

31 March 2020

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The consequences of Rad51 overexpression for normal and tumor cells

31 March 2020

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DNA polymerases and cancer.

31 March 2020

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Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers.

31 March 2020

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Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks

31 March 2020

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Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.

31 March 2020

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Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication

31 March 2020

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DNA polymerase zeta is required for proliferation of normal mammalian cells

31 March 2020

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Regulation of PCNA-protein interactions for genome stability

31 March 2020

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SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis

31 March 2020

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Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

31 March 2020

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HLTF gene silencing in human colon cancer

31 March 2020

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

31 March 2020

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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

31 March 2020

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The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

31 March 2020

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Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions

31 March 2020

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End-joining, translocations and cancer

31 March 2020

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Analysis of PALB2/FANCN-associated breast cancer families

31 March 2020

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Breast-cancer risk in families with mutations in PALB2

31 March 2020

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Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.

31 March 2020

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Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.

31 March 2020

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Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

31 March 2020

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Aberrant chromosome morphology in human cells defective for Holliday junction resolution

31 March 2020

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Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

31 March 2020

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Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations

31 March 2020

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Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells.

31 March 2020

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Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

31 March 2020

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DNA breaks and chromosome pulverization from errors in mitosis

31 March 2020

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

31 March 2020

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Molecular mechanisms underlying RB protein function

31 March 2020

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Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion

31 March 2020

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BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges

31 March 2020

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Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

31 March 2020

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The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

31 March 2020

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MUS81 promotes common fragile site expression.

31 March 2020

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ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

31 March 2020

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Replication stress links structural and numerical cancer chromosomal instability

31 March 2020

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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

31 March 2020

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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

31 March 2020

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Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

31 March 2020

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Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress.

31 March 2020

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Selective killing of cancer cells by suppression of geminin activity

31 March 2020

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NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells

31 March 2020

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The DNA-damage response in human biology and disease

31 March 2020

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UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

31 March 2020

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Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.

31 March 2020

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Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase

31 March 2020

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Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

31 March 2020

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

31 March 2020

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Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.

31 March 2020

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

31 March 2020

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

31 March 2020

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Predictive biomarkers for cancer therapy with PARP inhibitors.

31 March 2020

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Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint

31 March 2020

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Break-induced replication repair of damaged forks induces genomic duplications in human cells.

31 March 2020

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Eukaryotic chromosome DNA replication: where, when, and how?

31 March 2020

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31 March 2020

Chromosome fragile sites

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Common fragile sites: mechanisms of instability revisited.

31 March 2020

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Expanded CAG repeats activate the DNA damage checkpoint pathway

31 March 2020

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ATR Regulates Fragile Site Stability

31 March 2020

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Constitutive fragile sites and cancer.

31 March 2020

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Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites

31 March 2020

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Signatures of mutation and selection in the cancer genome

31 March 2020

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Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

31 March 2020

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DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells

31 March 2020

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A role for common fragile site induction in amplification of human oncogenes

31 March 2020

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The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers.

31 March 2020

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The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

31 March 2020

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Targeted deletion of Wwox reveals a tumor suppressor function

31 March 2020

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Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

31 March 2020

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Molecular profiling of common fragile sites in human fibroblasts.

31 March 2020

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Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

31 March 2020

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Identification of early replicating fragile sites that contribute to genome instability

31 March 2020

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Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

31 March 2020

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Transcription and recombination: when RNA meets DNA.

31 March 2020

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Oncogenic potential of the DNA replication licensing protein CDT1

31 March 2020

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Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53.

31 March 2020

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Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer.

31 March 2020

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Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression

31 March 2020

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Fen1 mutations result in autoimmunity, chronic inflammation and cancers

31 March 2020

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Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.

31 March 2020

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Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms

31 March 2020

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Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme

31 March 2020

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Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas

31 March 2020

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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

31 March 2020

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Atm-deficient mice: a paradigm of ataxia telangiectasia

31 March 2020

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

31 March 2020

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Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

31 March 2020

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Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

31 March 2020

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Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage

31 March 2020

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Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.

31 March 2020

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Loss of DNA polymerase zeta enhances spontaneous tumorigenesis

31 March 2020

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RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

31 March 2020

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Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome

31 March 2020

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Cancer predisposition caused by elevated mitotic recombination in Bloom mice

31 March 2020

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Functional Interplay of p53 and Mus81 in DNA Damage Responses and Cancer

31 March 2020

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Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair

31 March 2020

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

31 March 2020

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Tumorigenesis in mice carrying a truncating Brca1 mutation

31 March 2020

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Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

31 March 2020

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Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice

31 March 2020

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

31 March 2020

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12 December 2020

Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors

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12 December 2020

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

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12 December 2020

Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.

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12 December 2020

Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.

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12 December 2020

Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice

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12 December 2020

Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma

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12 December 2020

Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability

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12 December 2020

Identifiers

DOI

10.1038/NRC3916

1 reference

Dimensions Publication ID

2 August 2017

1004022288

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