(Q47557278)

English

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.

scientific article published on 23 January 2018

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scholarly article

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12 March 2020

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Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms (English)

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biomedical investigative technique

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19 September 2019

human digestive system

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7 October 2019

circulatory system

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10 October 2019

integumentary system

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21 October 2019

6

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Delilah F G Hendriks

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author name string

Chris S Pridgeon

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Constanze Schlott

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Min Wei Wong

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Minne B Heringa

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Tobias Heckel

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Laurence Launay

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Vitalina Gryshkova

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Stefan Przyborski

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Rachel N Bearon

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Emma L Wilkinson

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Tahera Ansari

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John Greenman

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Sue Gibbs

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James Sidaway

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Rowena L Sison-Young

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Paul Walker

18

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Mike J Cross

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B Kevin Park

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Chris E P Goldring

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publication date

23 January 2018

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number of pages

13

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based on heuristic

inferred from page(s)

Archives of Toxicology

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29 June 2019

19 September 2019

7 October 2019

10 October 2019

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copyright license

Creative Commons Attribution 4.0 International

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29 June 2019

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copyright status

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0 references

Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail

1 reference

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22 May 2018

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

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Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

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State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies

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22 May 2018

Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues

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22 May 2018

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

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Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats

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A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

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22 May 2018

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

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Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

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In silico toxicology: computational methods for the prediction of chemical toxicity

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Novel in vitro and mathematical models for the prediction of chemical toxicity

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Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

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Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

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Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts

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MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure.

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A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents.

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Human iPSC-based cardiac microphysiological system for drug screening applications.

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Biomimetic 3D Tissue Models for Advanced High-Throughput Drug Screening.

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Implementation of quantitative and systems pharmacology in large pharma

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Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

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Dermal xenobiotic metabolism: a comparison between native human skin, four in vitro skin test systems and a liver system

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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

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Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors

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The use of skin models in drug development

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The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

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The concept of multispecies testing in industrial toxicology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818581

14 August 2018

Characterization of a new tissue-engineered human skin equivalent with hair.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Information needed to conduct first-in-human oncology trials in the United States: a view from a former FDA medical reviewer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analytical pharmacology: the impact of numbers on pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The European Medicines Agency: an overview of its mission, responsibilities, and recent initiatives in cancer drug regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? II. Construction and analysis of a consolidated database

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterisation of porcine dermis scaffolds decellularised using a novel non-enzymatic method for biomedical applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lessons from the fatal French study BIA-10-2474

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00204-018-2152-9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29362863%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29362863%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29362863%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

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