(Q47568436)

4 February 2018

title

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers (English)

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4 February 2018

author

Attila Gursoy

3

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4 February 2018

Ruth Nussinov

5

object named as

Ruth Nussinov

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4 February 2018

1

Hyunbum Jang

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4 February 2018

Özlem Keskin

4

object named as

Ozlem Keskin

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4 February 2018

Serena Muratcioglu

2

object named as

Serena Muratcioglu

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4 February 2018

language of work or name

English

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publication date

7 April 2016

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4 February 2018

number of pages

14

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inferred from page(s)

published in

Biochemical Journal

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4 February 2018

volume

473

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4 February 2018

issue

12

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4 February 2018

page(s)

1719-1732

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4 February 2018

Molecular dynamics simulation of the gramicidin channel in a phospholipid bilayer

cites work

1 reference

12 December 2020

Functional interactions in bacteriorhodopsin: a theoretical analysis of retinal hydrogen bonding with water

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12 December 2020

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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12 December 2020

Structure, energetics, and dynamics of lipid-protein interactions: A molecular dynamics study of the gramicidin A channel in a DMPC bilayer

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12 December 2020

Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane

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12 December 2020

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

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12 December 2020

Formation of the Ras dimer is essential for Raf-1 activation

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12 December 2020

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

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12 December 2020

Free energy calculations on dimer stability of the HIV protease using molecular dynamics and a continuum solvent model

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12 December 2020

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

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12 December 2020

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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12 December 2020

Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes.

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12 December 2020

On the nonpolar hydration free energy of proteins: surface area and continuum solvent models for the solute-solvent interaction energy.

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12 December 2020

Identification of residues and domains of Raf important for function in vivo and in vitro

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12 December 2020

Single-molecule imaging analysis of Ras activation in living cells

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12 December 2020

How environment supports a state: molecular dynamics simulations of two states in bacteriorhodopsin suggest lipid and water compensation

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12 December 2020

The RAF proteins take centre stage

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12 December 2020

Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.

1 reference

12 December 2020

PRISM: protein interactions by structural matching

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12 December 2020

Ras signaling from plasma membrane and endomembrane microdomains

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12 December 2020

Study of the insulin dimerization: binding free energy calculations and per-residue free energy decomposition

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12 December 2020

Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding

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12 December 2020

Scalable molecular dynamics with NAMD

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12 December 2020

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

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12 December 2020

Plasma membrane nanoswitches generate high-fidelity Ras signal transduction

1 reference

12 December 2020

Interactions of Ras proteins with the plasma membrane and their roles in signaling.

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12 December 2020

Galectin-1 is a novel structural component and a major regulator of h-ras nanoclusters

1 reference

12 December 2020

Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.

1 reference

12 December 2020

Ras oncogenes: split personalities

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12 December 2020

A dimerization-dependent mechanism drives RAF catalytic activation

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12 December 2020

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

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12 December 2020

Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

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12 December 2020

β-Barrel topology of Alzheimer's β-amyloid ion channels

1 reference

12 December 2020

RAS Interaction with PI3K: More Than Just Another Effector Pathway

1 reference

12 December 2020

The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery

1 reference

12 December 2020

Predicting protein-protein interactions on a proteome scale by matching evolutionary and structural similarities at interfaces using PRISM.

1 reference

12 December 2020

Regulating the regulator: post-translational modification of RAS

1 reference

12 December 2020

Raf inhibitors target ras spatiotemporal dynamics

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12 December 2020

Organization, dynamics, and segregation of Ras nanoclusters in membrane domains

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12 December 2020

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

1 reference

12 December 2020

N-Ras forms dimers at POPC membranes

1 reference

12 December 2020

It takes two to tango--signalling by dimeric Raf kinases

1 reference

12 December 2020

The spatial structure of cell signaling systems

1 reference

12 December 2020

The importance of Raf dimerization in cell signaling

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12 December 2020

Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling

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12 December 2020

Discovery and saturation analysis of cancer genes across 21 tumour types

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12 December 2020

H-Ras forms dimers on membrane surfaces via a protein-protein interface.

1 reference

12 December 2020

Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs

1 reference

12 December 2020

Dragging ras back in the ring

1 reference

12 December 2020

Oligomerization and nanocluster organization render specificity

1 reference

12 December 2020

Ras nanoclusters: Versatile lipid-based signaling platforms

1 reference

12 December 2020

Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region

1 reference

12 December 2020

GTP-Dependent K-Ras Dimerization

1 reference

12 December 2020

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

1 reference

12 December 2020

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

1 reference

12 December 2020

The Ras G Domain Lacks the Intrinsic Propensity to Form Dimers

1 reference

12 December 2020

Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target

1 reference

12 December 2020

Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.

1 reference

12 December 2020

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site

1 reference

12 December 2020

Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation

1 reference

12 December 2020

A New View of Ras Isoforms in Cancers

1 reference

12 December 2020

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

1 reference

12 December 2020

The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding

1 reference

12 December 2020

The higher level of complexity of K-Ras4B activation at the membrane

1 reference

12 December 2020

Identifiers

DOI

10.1042/BCJ20160031

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4 February 2018

PMC publication ID

7830773

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1 reference

4 February 2018