(Q47595394)

4 February 2018

title

Small-cell lung cancer: what we know, what we need to know and the path forward. (English)

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4 February 2018

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Adi F Gazdar

1

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4 February 2018

Paul A Bunn

series ordinal

2

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4 February 2018

John D Minna

series ordinal

3

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4 February 2018

language of work or name

English

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publication date

27 October 2017

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4 February 2018

published in

Nature Reviews Cancer

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4 February 2018

volume

17

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4 February 2018

issue

12

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4 February 2018

page(s)

725-737

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4 February 2018

https://scigraph.springernature.com/pub.10.1038/nrc.2017.87

exact match

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21 January 2018

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Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers

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21 January 2018

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21 January 2018

Chromosome fragile sites

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NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas

21 January 2018

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A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

21 January 2018

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From fly wings to targeted cancer therapies: a centennial for notch signaling

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Is the Canonical RAF/MEK/ERK Signaling Pathway a Therapeutic Target in SCLC?

21 January 2018

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Targeting the cancer epigenome for therapy

21 January 2018

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The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells

21 January 2018

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DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2.

21 January 2018

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EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway

21 January 2018

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Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours.

21 January 2018

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Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Targeting EZH2 in cancer

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Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

21 January 2018

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Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).

21 January 2018

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Bromodomain and hedgehog pathway targets in small cell lung cancer

21 January 2018

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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

21 January 2018

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Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.

21 January 2018

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EZH2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation

21 January 2018

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Developing EZH2-Targeted Therapy for Lung Cancer

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Antitumor activity of LSD1 inhibitors in lung cancer

21 January 2018

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A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.

21 January 2018

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Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

21 January 2018

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NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer

21 January 2018

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Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients

21 January 2018

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Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility

21 January 2018

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Opening a Chromatin Gate to Metastasis

21 January 2018

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Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression.

21 January 2018

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Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer.

21 January 2018

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The schlafen family of proteins and their regulation by interferons

21 January 2018

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21 January 2018

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21 January 2018

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MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway.

21 January 2018

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CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib.

21 January 2018

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Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

21 January 2018

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21 January 2018

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p53: a frequent target for genetic abnormalities in lung cancer.

21 January 2018

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Pathogenesis of lung cancer signalling pathways: roadmap for therapies

21 January 2018

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21 January 2018

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21 January 2018

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CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

21 January 2018

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The clinical utility of circulating tumour cells in patients with small cell lung cancer

21 January 2018

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Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation.

21 January 2018

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Lung cancer-initiating cells: a novel target for cancer therapy

21 January 2018

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Paraneoplastic syndromes associated with lung cancer

21 January 2018

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Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

21 January 2018

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Somatostatin Receptors in Lung Cancer: From Function to Molecular Imaging and Therapeutics

21 January 2018

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Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies.

21 January 2018

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Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.

21 January 2018

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History of small-cell lung cancer

21 January 2018

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Ectopic ACTH production in carcinoma of the lung

21 January 2018

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Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung

21 January 2018

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Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

21 January 2018

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Mouse models for human lung cancer

21 January 2018

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The International Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung ca

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Possible roles of DLK1 in the Notch pathway during development and disease

21 January 2018

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The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells

21 January 2018

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Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

21 January 2018

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ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers

21 January 2018

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Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2.

21 January 2018

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Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells

21 January 2018

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Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

21 January 2018

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Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations

21 January 2018

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21 January 2018

Mouse models of cancer

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From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers

21 January 2018

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Genetically engineered mouse models: closing the gap between preclinical data and trial outcomes

21 January 2018

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Preclinical Murine Models for Lung Cancer: Clinical Trial Applications

21 January 2018

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Mouse models of chemically-induced lung carcinogenesis

21 January 2018

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Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma

21 January 2018

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Evaluation of novel orthotopic nude mouse models for human small-cell lung cancer

21 January 2018

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Clinical relevance of human cancer xenografts as a tool for preclinical assessment: example of in-vivo evaluation of topotecan-based chemotherapy in a panel of human small-cell lung cancer xenografts

21 January 2018

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New metastatic model of human small-cell lung cancer by orthotopic transplantation in mice

21 January 2018

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Heterotransplantation of small-cell carcinoma of the lung into nude mice: Comparison of intracranial and subcutaneous routes

21 January 2018

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One mouse, one patient paradigm: New avatars of personalized cancer therapy

21 January 2018

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5-Hydroxytryptophan Uptake by Dog Thyroid ‘C’ Cells, and its Possible Significance in Polypeptide Hormone Production

21 January 2018

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Amplification and expression of the c-myc oncogene in human lung cancer cell lines

21 January 2018

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L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

21 January 2018

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Oat-cell carcinoma of the lung. Its origin and relationship to bronchial carcinoid

21 January 2018

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The diffuse neuroendocrine system: peptides, amines, placodes and the APUD theory.

31 March 2020

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"APUD" cells: fact and fiction

31 March 2020

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TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies

31 March 2020

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Small cell, big problem! Stem cells, root cause?

31 March 2020

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Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model

31 March 2020

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Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23)

31 March 2020

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Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2017.87

A genetic snapshot of small cell lung cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2017.87

The serum-free establishment and in vitro growth properties of classic and variant small cell lung cancer cell lines

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2017.87

Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target

31 March 2020

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7 January 2021

Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer.

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https://api.crossref.org/works/10.1038%2FNRC.2017.87

7 January 2021

Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitonin

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https://api.crossref.org/works/10.1038%2FNRC.2017.87

7 January 2021

NCI series of cell lines: an historical perspective

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7 January 2021

Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

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7 January 2021

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

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12 December 2020

Molecular changes in the bronchial epithelium of patients with small cell lung cancer

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12 December 2020

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12 December 2020

Intracranial Growth of Pulmonary Small Cell Carcinoma Cells in Nude Athymic Mice

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12 December 2020

Liquid biopsies in lung cancer: the new ambrosia of researchers.

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12 December 2020

A new floating cell line derived from human pulmonary carcinoma of oat cell type

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12 December 2020

Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives

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12 December 2020

Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential

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12 December 2020

Growth of human small cell (oat cell) carcinoma of the lung in serum-free growth factor-supplemented medium

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12 December 2020

Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer

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12 December 2020

Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties

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12 December 2020

In vitro radiation and chemotherapy sensitivity of established cell lines of human small cell lung cancer and its large cell morphological variants

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12 December 2020

Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities.

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12 December 2020

Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties

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12 December 2020

Keynote address on biostatistics and data retrieval.

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12 December 2020

Paraneoplastic syndromes: the way to an early diagnosis of lung cancer

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12 December 2020

The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium

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12 December 2020

Establishment and identification of small cell lung cancer cell lines having classic and variant features.

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12 December 2020

NCI-Navy Medical Oncology Branch cell line data base

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12 December 2020

myc family DNA amplification in tumors and tumor cell lines from patients with small-cell lung cancer

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12 December 2020

Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.

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12 December 2020

Cancer stem cells in small cell lung cancer

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12 December 2020

Cancer stem cells and tumor transdifferentiation: implications for novel therapeutic strategies

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12 December 2020

High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints

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12 December 2020

myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens

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Identifiers

DOI

10.1038/NRC.2017.87

1 reference

4 February 2018

1 reference

4 February 2018