(Q47659073)

4 February 2018

title

Necroptotic cell death in anti-cancer therapy (English)

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4 February 2018

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5

Claus Bachert

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4 February 2018

Dmitri V Krysko

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Katharina D'Herde

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Katharina D'Herde

4

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Peter Vandenabeele

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Peter Vandenabeele

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Valerian E. Kagan

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object named as

Valerian E Kagan

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4 February 2018

author name string

Olga Krysko

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4 February 2018

Tania Løve Aaes

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4 February 2018

Luc Leybaert

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4 February 2018

publication date

1 November 2017

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4 February 2018

published in

Immunological Reviews

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4 February 2018

volume

280

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4 February 2018

issue

1

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4 February 2018

page(s)

207-219

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4 February 2018

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

cites work

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

21 January 2018

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Necroptosis: Mechanisms and Relevance to Disease

21 January 2018

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Necroptosis and its role in inflammation

21 January 2018

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Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine.

21 January 2018

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Caspase-8: regulating life and death

21 January 2018

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

21 January 2018

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Ferroptosis: bug or feature?

21 January 2018

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Ferroptosis Inhibition: Mechanisms and Opportunities

21 January 2018

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Inflammasomes as polyvalent cell death platforms

21 January 2018

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DNA damage and the balance between survival and death in cancer biology

21 January 2018

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Immunogenic cell death and DAMPs in cancer therapy

21 January 2018

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Immunogenic cell death in cancer and infectious disease

21 January 2018

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Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

21 January 2018

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RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.

21 January 2018

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Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

21 January 2018

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Consensus guidelines for the detection of immunogenic cell death

21 January 2018

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Alarmins: chemotactic activators of immune responses

21 January 2018

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Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

21 January 2018

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Initiation and execution mechanisms of necroptosis: an overview

21 January 2018

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MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

21 January 2018

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Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

21 January 2018

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The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

21 January 2018

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ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences

21 January 2018

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Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

21 January 2018

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Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

21 January 2018

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

21 January 2018

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Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium

21 January 2018

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Emerging roles for lipids in non-apoptotic cell death

21 January 2018

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TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

21 January 2018

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Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

21 January 2018

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A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

21 January 2018

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Calreticulin exposure dictates the immunogenicity of cancer cell death

21 January 2018

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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors

21 January 2018

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Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

21 January 2018

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Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

21 January 2018

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Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

21 January 2018

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Caspase-8 in cancer biology and therapy

21 January 2018

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A dual role for Caspase8 and NF-κB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival

21 January 2018

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

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Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

21 January 2018

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Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice

21 January 2018

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Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

21 January 2018

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Induction of tumor cell apoptosis or necrosis by conditional expression of cell death proteins: analysis of cell death pathways and in vitro immune stimulatory potential.

21 January 2018

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Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

21 January 2018

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An Inflammatory Perspective on Necroptosis

21 January 2018

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Mechanisms of internalization of apoptotic and necrotic L929 cells by a macrophage cell line studied by electron microscopy

21 January 2018

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Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells

21 January 2018

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Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

21 January 2018

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PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.

21 January 2018

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RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1α release, and efficient paracrine dendritic cell activation

21 January 2018

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Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

21 January 2018

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Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo

21 January 2018

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Primary sterile necrotic cells fail to cross-prime CD8(+) T cells

21 January 2018

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Extracellular ATP and P₂X₇ receptor exert context-specific immunogenic effects after immunogenic cancer cell death.

21 January 2018

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Necrosis is associated with IL-6 production but apoptosis is not.

21 January 2018

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Protein synthesis persists during necrotic cell death

21 January 2018

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Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts

21 January 2018

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Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

21 January 2018

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

21 January 2018

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Phosphatidylserine exposure during early primary necrosis (oncosis) in JB6 cells as evidenced by immunogold labeling technique

21 January 2018

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Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms

21 January 2018

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Calcium-dependent phospholipid scrambling by TMEM16F

21 January 2018

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21 January 2018

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Necrosome core machinery: MLKL.

21 January 2018

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Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2

21 January 2018

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Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

21 January 2018

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Apoptosis and necrosis: detection, discrimination and phagocytosis

21 January 2018

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Methods for distinguishing apoptotic from necrotic cells and measuring their clearance

21 January 2018

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A real-time fluorometric method for the simultaneous detection of cell death type and rate

21 January 2018

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

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Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

21 January 2018

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Pro-necrotic molecules impact local immunosurveillance in human breast cancer

21 January 2018

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Receptor-interacting protein kinase 3 is a predictor of survival and plays a tumor suppressive role in colorectal cancer.

21 January 2018

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RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage

21 January 2018

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RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells

21 January 2018

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Absence of RIPK3 predicts necroptosis resistance in malignant melanoma

21 January 2018

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Killing AML: RIPK3 leads the way.

21 January 2018

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RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation

21 January 2018

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Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis

21 January 2018

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Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma.

21 January 2018

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Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

21 January 2018

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Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells.

21 January 2018

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Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

21 January 2018

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Adoptive cell transfer as personalized immunotherapy for human cancer

21 January 2018

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NecroX as a novel class of mitochondrial reactive oxygen species and ONOO⁻ scavenger.

21 January 2018

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T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

21 January 2018

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The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression.

21 January 2018

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RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.

21 January 2018

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RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation

21 January 2018

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Key roles of necroptotic factors in promoting tumor growth

21 January 2018

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Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.

21 January 2018

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Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

21 January 2018

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Dishonorable discharge: the oncogenic roles of cleaved E-cadherin fragments

21 January 2018

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RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function.

21 January 2018

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The evidence for and against different modes of tumour cell extravasation in the lung: diapedesis, capillary destruction, necroptosis, and endothelialization

21 January 2018

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Dendritic-cell-based therapeutic cancer vaccines

21 January 2018

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Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters

21 January 2018

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Clearance of dead cells: mechanisms, immune responses and implication in the development of diseases.

21 January 2018

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A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis

21 January 2018

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From regulation of dying cell engulfment to development of anti-cancer therapy

21 January 2018

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Exposure of anionic phospholipids serves as anti-inflammatory and immunosuppressive signal--implications for antiphospholipid syndrome and systemic lupus erythematosus.

21 January 2018

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Clearance of apoptotic and necrotic cells and its immunological consequences

21 January 2018

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Killing colon cancer cells through PCD pathways by a novel hyaluronic acid-modified shell-core nanoparticle loaded with RIP3 in combination with chloroquine

21 January 2018

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Ferroptosis: an iron-dependent form of nonapoptotic cell death

21 January 2018

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Regulated necrosis: disease relevance and therapeutic opportunities

21 January 2018

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

21 January 2018

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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

21 January 2018

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Ferroptosis: Oxidized PEs trigger death.

21 January 2018

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Iron addiction: a novel therapeutic target in ovarian cancer

21 January 2018

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Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

21 January 2018

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Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB.

21 January 2018

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MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome.

21 January 2018

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RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12583

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4 February 2018

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4 February 2018