(Q38319916)

2 September 2017

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title

Necroptosis and its role in inflammation (English)

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2 September 2017

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Manolis Pasparakis

1

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Peter Vandenabeele

object named as

Peter Vandenabeele

series ordinal

2

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language of work or name

English

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publication date

1 January 2015

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2 September 2017

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2 September 2017

517

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2 September 2017

311-320

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2 September 2017

7534

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https://scigraph.springernature.com/pub.10.1038/nature14191

2 September 2017

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cites work

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

1 reference

12 December 2020

RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein

1 reference

12 December 2020

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

1 reference

12 December 2020

Epithelial NEMO links innate immunity to chronic intestinal inflammation

1 reference

12 December 2020

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

1 reference

12 December 2020

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

1 reference

12 December 2020

cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis

1 reference

12 December 2020

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

1 reference

12 December 2020

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

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12 December 2020

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis

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12 December 2020

Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis

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12 December 2020

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

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12 December 2020

Functional complementation between FADD and RIP1 in embryos and lymphocytes

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12 December 2020

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

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12 December 2020

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

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12 December 2020

A plug release mechanism for membrane permeation by MLKL.

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12 December 2020

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

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12 December 2020

Mechanisms and functions of inflammasomes

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12 December 2020

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

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12 December 2020

Molecular mechanisms of necroptosis: an ordered cellular explosion

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12 December 2020

Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein

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12 December 2020

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

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12 December 2020

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

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12 December 2020

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

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12 December 2020

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

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12 December 2020

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

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12 December 2020

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

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12 December 2020

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

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12 December 2020

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

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12 December 2020

Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.

1 reference

12 December 2020

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

1 reference

12 December 2020

Single-cell imaging of caspase-1 dynamics reveals an all-or-none inflammasome signaling response.

1 reference

12 December 2020

RIPK3 as a potential therapeutic target for Gaucher's disease.

1 reference

12 December 2020

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.

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12 December 2020

A long-awaited merger of the pathways mediating host defence and programmed cell death.

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12 December 2020

Immunogenic cell death and DAMPs in cancer therapy

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12 December 2020

RIPK3-mediated necroptosis regulates cardiac allograft rejection.

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12 December 2020

Receptor-interacting protein kinase 3 deficiency inhibits immune cell infiltration and attenuates organ injury in sepsis

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12 December 2020

Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

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12 December 2020

Death receptor signal transducers: nodes of coordination in immune signaling networks

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12 December 2020

Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.

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12 December 2020

Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice

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12 December 2020

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

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12 December 2020

Fas/CD95-induced chemokines can serve as "find-me" signals for apoptotic cells

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12 December 2020

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

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12 December 2020

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

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12 December 2020

Apoptotic cell clearance: basic biology and therapeutic potential.

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12 December 2020

Pattern recognition receptors and inflammation

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12 December 2020

Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways

1 reference

12 December 2020

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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12 December 2020

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.

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12 December 2020

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

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12 December 2020

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

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12 December 2020

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

1 reference

12 December 2020

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

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12 December 2020

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

1 reference

12 December 2020

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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12 December 2020

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

1 reference

12 December 2020

NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling

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12 December 2020

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

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12 December 2020

The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair

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12 December 2020

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

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12 December 2020

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

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12 December 2020

Concepts of tissue injury and cell death in inflammation: a historical perspective.

1 reference

12 December 2020

Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection

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12 December 2020

Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α

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12 December 2020

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.

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12 December 2020

An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions.

1 reference

12 December 2020

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

1 reference

12 December 2020

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

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12 December 2020

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

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12 December 2020

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

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12 December 2020

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

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12 December 2020

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

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12 December 2020

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

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12 December 2020

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

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12 December 2020

Caspase 8 inhibits programmed necrosis by processing CYLD

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12 December 2020

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

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12 December 2020

Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein

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12 December 2020

Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells

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12 December 2020

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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12 December 2020

Necroptosis is active in children with inflammatory bowel disease and contributes to heighten intestinal inflammation

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12 December 2020

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

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12 December 2020

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

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12 December 2020

RIPK3-mediated necroptosis promotes donor kidney inflammatory injury and reduces allograft survival.

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12 December 2020

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

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12 December 2020

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

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12 December 2020

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

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12 December 2020

Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium

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12 December 2020

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration.

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12 December 2020

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

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12 December 2020

Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs

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12 December 2020

NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling

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12 December 2020

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

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12 December 2020

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

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12 December 2020

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

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12 December 2020

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

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12 December 2020

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8

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12 December 2020

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

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12 December 2020

Identification of RIP1 kinase as a specific cellular target of necrostatins

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12 December 2020

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

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12 December 2020

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

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12 December 2020

Control of life-or-death decisions by RIP1 kinase

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12 December 2020

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

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12 December 2020

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

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12 December 2020

Protective roles for caspase-8 and cFLIP in adult homeostasis.

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12 December 2020

Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner

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12 December 2020

A role of RIP3-mediated macrophage necrosis in atherosclerosis development.

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12 December 2020

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

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12 December 2020

Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8.

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12 December 2020

Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma.

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12 December 2020

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

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12 December 2020

TNF-alpha induces two distinct caspase-8 activation pathways

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12 December 2020

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

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12 December 2020

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

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12 December 2020

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

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12 December 2020

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

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12 December 2020

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

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12 December 2020

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

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12 December 2020

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

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12 December 2020

Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice

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12 December 2020

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.

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12 December 2020

FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

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12 December 2020

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.

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12 December 2020

RIP3 induces apoptosis independent of pronecrotic kinase activity

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Crossref

https://api.crossref.org/works/10.1038%2FNATURE14191

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE14191

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PubMed ID

25592536

Dimensions Publication ID

2 September 2017

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1 reference

PubMed ID

25592536