(Q38699324)

2 July 2019

title

Regulated necrosis: disease relevance and therapeutic opportunities (English)

1 reference

2 July 2019

Jose Pedro Friedmann Angeli

author

object named as

José Pedro Friedmann Angeli

2

0 references

Marcus Conrad

object named as

Marcus Conrad

1

0 references

Peter Vandenabeele

object named as

Peter Vandenabeele

3

0 references

author name string

Brent R Stockwell

4

1 reference

2 July 2019

publication date

18 January 2016

1 reference

2 July 2019

Nature Reviews Drug Discovery

published in

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2 July 2019

volume

15

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2 July 2019

issue

5

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2 July 2019

page(s)

348-366

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2 July 2019

https://scigraph.springernature.com/pub.10.1038/nrd.2015.6

exact match

0 references

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31 March 2020

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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

31 March 2020

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RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

31 March 2020

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Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

31 March 2020

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Inhibition of cystine uptake disrupts the growth of primary brain tumors

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Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway

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31 March 2020

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Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

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Altretamine (hexamethylmelamine) in the treatment of platinum-resistant ovarian cancer: a phase II study

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Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

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Poly(ADP-ribose) signaling in cell death

31 March 2020

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Therapeutic applications of PARP inhibitors: anticancer therapy and beyond

31 March 2020

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ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress

31 March 2020

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Mitochondrial and nuclear cross talk in cell death: parthanatos

31 March 2020

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Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

31 March 2020

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31 March 2020

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PARP inhibition attenuates histopathological lesion in ischemia/reperfusion renal mouse model after cold prolonged ischemia.

31 March 2020

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PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.

31 March 2020

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Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents

31 March 2020

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The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

31 March 2020

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31 March 2020

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A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primar

31 March 2020

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Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

31 March 2020

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Cyclophilin D gene ablation protects mice from ischemic renal injury.

31 March 2020

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Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

31 March 2020

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Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis

31 March 2020

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Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency

31 March 2020

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Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis

31 March 2020

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Dimers of mitochondrial ATP synthase form the permeability transition pore

31 March 2020

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Novel insights into the mitochondrial permeability transition

31 March 2020

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Cell biology. Metabolic control of cell death

31 March 2020

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p53 opens the mitochondrial permeability transition pore to trigger necrosis

31 March 2020

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Is p53 the Long-Sought Molecular Trigger for Cyclophilin D–Regulated Mitochondrial Permeability Transition Pore Formation and Necrosis?

31 March 2020

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

31 March 2020

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

31 March 2020

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Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

31 March 2020

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Inhibition of cell cycle progression by the novel cyclophilin ligand sanglifehrin A is mediated through the NFkappa B-dependent activation of p53.

31 March 2020

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Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A.

31 March 2020

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Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

31 March 2020

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Cyclosporine in acute ischemic stroke.

31 March 2020

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Calcineurin inhibitors in heart transplantation

31 March 2020

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Necroptosis and parthanatos are involved in remote lung injury after receiving ischemic renal allografts in rats.

31 March 2020

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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

31 March 2020

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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

31 March 2020

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Mechanisms and functions of inflammasomes

31 March 2020

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Pyroptosis: host cell death and inflammation

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Mechanisms of necroptosis in T cells

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Virus inhibition of RIP3-dependent necrosis

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31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Oxytosis: A novel form of programmed cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Baicalein and 12/15-lipoxygenase in the ischemic brain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

AIF depletion provides neuroprotection through a preconditioning effect.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Caspase 8 inhibits programmed necrosis by processing CYLD

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Smac mimetics as IAP antagonists

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of L-glutamate and L-cystine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Neuroprotection by the PARP inhibitor PJ34 modulates cerebral and circulating RAGE levels in rats exposed to focal brain ischemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Benzamide, a poly(ADP-ribose) polymerase inhibitor, is neuroprotective against soman-induced seizure-related brain damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Novel inhibitors of poly(ADP-ribose) synthetase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Novel lipoxygenase inhibitors as neuroprotective reagents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

31 March 2020

A history of vitamin E.

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Synergistic protective effect of cyclosporin A and rotenone against hypoxia-reoxygenation in cardiomyocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.6

Proceedings: Experimental manipulation of the specific activity of poly(ADP-ribose) polymerase

31 March 2020

1 reference

12 December 2020

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

1 reference

12 December 2020

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor

1 reference

12 December 2020

Changes in selenoprotein P in substantia nigra and putamen in Parkinson's disease

1 reference

12 December 2020

Mitochondrial permeability transition and cell death: the role of cyclophilin d

1 reference

12 December 2020

Exchange of cystine and glutamate across plasma membrane of human fibroblasts

1 reference

12 December 2020

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1 reference

12 December 2020

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis

1 reference

12 December 2020

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD.2015.6

1 reference

2 July 2019

PMCID

6531857

1 reference

2 July 2019

PubMed ID

26775689

1 reference

2 July 2019