(Q47737258)

5 February 2018

title

NAD+ Deficits in Age-Related Diseases and Cancer (English)

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5 February 2018

author

Nabil Djouder

series ordinal

2

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5 February 2018

author name string

Amanda Garrido

series ordinal

1

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5 February 2018

publication date

3 July 2017

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5 February 2018

published in

Trends in cancer

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5 February 2018

volume

3

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5 February 2018

issue

8

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5 February 2018

page(s)

593-610

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5 February 2018

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice.

7 January 2021

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Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion

7 January 2021

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7 January 2021

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Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

7 January 2021

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Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

7 January 2021

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NAD+ metabolism in health and disease

7 January 2021

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CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells

7 January 2021

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Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

7 January 2021

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NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

7 January 2021

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7 January 2021

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7 January 2021

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NAD+ and sirtuins in aging and disease

7 January 2021

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NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer

7 January 2021

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Extension of human cell lifespan by nicotinamide phosphoribosyltransferase

7 January 2021

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NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice.

7 January 2021

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NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance

7 January 2021

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Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer.

7 January 2021

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A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT.

7 January 2021

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Regulative Effect of Nampt on Tumor Progression and Cell Viability in Human Colorectal Cancer.

7 January 2021

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DNA double strand break repair, aging and the chromatin connection.

7 January 2021

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DNA repair, genome stability, and aging

7 January 2021

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(ADP-ribose)n participates in DNA excision repair

7 January 2021

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PARP inhibition: PARP1 and beyond

7 January 2021

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The response of Parp knockout mice against DNA damaging agents.

7 January 2021

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Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation)

7 January 2021

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Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination

7 January 2021

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Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

7 January 2021

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Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression

7 January 2021

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

7 January 2021

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PARP-2 regulates SIRT1 expression and whole-body energy expenditure

7 January 2021

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Oncogene-induced NAD(+) depletion in tumorigenesis

7 January 2021

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Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

7 January 2021

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The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

7 January 2021

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Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

7 January 2021

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A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

7 January 2021

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Newly discovered anti-inflammatory properties of the benzamides and nicotinamides

7 January 2021

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Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Extrachromosomal rDNA circles--a cause of aging in yeast

7 January 2021

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Sirtuins in glucose and lipid metabolism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

HDL as a target in the treatment of atherosclerotic cardiovascular disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SRT1720 improves survival and healthspan of obese mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Sirt1 protects against high-fat diet-induced metabolic damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SirT1 gain of function increases energy efficiency and prevents diabetes in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Sirtuin-3 modulates Bak- and Bax-dependent apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SIRT6 promotes DNA repair under stress by activating PARP1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Sirt6 regulates dendritic cell differentiation, maturation, and function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The sirtuin SIRT6 regulates lifespan in male mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Global burden of cancer attributable to high body-mass index in 2012: a population-based study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Caloric restriction in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Elevation of blood NAD level after moderate exercise in young women and mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Caloric restriction alters the feeding response of key metabolic enzyme genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The effect of chronic and acute dietary restriction on the growth and protein turnover of fast and slow types of rat skeletal muscle.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The effects of aging and chronic dietary restriction on whole body growth and protein turnover in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The effects of ageing and chronic dietary restriction on in vivo hepatic protein synthesis in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Effect of age and restricted feeding on polypeptide chain assembly kinetics in liver protein synthesis in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

The influence of chronic dietary intervention on protein turnover and growth of the diaphragm and extensor digitorum longus muscles of the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

A protein restriction-dependent sulfur code for longevity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Endogenous hydrogen sulfide production is essential for dietary restriction benefits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Safety assessment of nicotinamide riboside, a form of vitamin B3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Nicotinamide riboside kinase structures reveal new pathways to NAD+

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Pathway analysis of NAD+metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

NAD+ as a signaling molecule modulating metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRECAN.2017.06.001

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.TRECAN.2017.06.001

1 reference

5 February 2018

1 reference

5 February 2018