(Q48134701)

29 June 2018

title

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures (English)

1 reference

29 June 2018

author

Sancha Martin

8

1 reference

29 June 2018

Paul N Span

Paul N Span

22

0 references

Sunil R Lakhani

Sunil R Lakhani

23

0 references

Anne-Lise Børresen-Dale

20

Anne-Lise Børresen-Dale

1 reference

29 June 2018

Peter T Simpson

11

0 references

Dominik Glodzik

Dominik Glodzik

2

0 references

Keiran Raine

13

Keiran Raine

1 reference

29 June 2018

33

Serena Nik-Zainal

1 reference

29 June 2018

19

Marc J van de Vijver

1 reference

29 June 2018

3

Sandro Morganella

1 reference

29 June 2018

24

Anne Vincent-Salomon

1 reference

29 June 2018

32

Michael R Stratton

1 reference

PMC publication ID

5833945

Hendrik Gerard Stunnenberg

29 June 2018

18

Hendrik G Stunnenberg

1 reference

29 June 2018

Helen Davies

1

Helen Davies

1 reference

29 June 2018

Sandrine Boyault

9

Sandrine Boyault

1 reference

29 June 2018

Anieta M Sieuwerts

10

Anieta M Sieuwerts

1 reference

29 June 2018

28

Steven Van Laere

1 reference

29 June 2018

30

Alain Viari

1 reference

29 June 2018

6

Xueqing Zou

1 reference

29 June 2018

25

Christos Sotiriou

1 reference

29 June 2018

7

Manasa Ramakrishna

1 reference

29 June 2018

Lucy R Yates

4

1 reference

29 June 2018

Johan Staaf

5

1 reference

29 June 2018

Tari A King

12

1 reference

29 June 2018

Jorunn E Eyfjord

14

1 reference

29 June 2018

Gu Kong

15

1 reference

29 June 2018

Åke Borg

16

1 reference

29 June 2018

John W M Martens

21

1 reference

29 June 2018

Andrew Tutt

26

1 reference

29 June 2018

Alastair M Thompson

27

1 reference

29 June 2018

Andrea L Richardson

29

1 reference

29 June 2018

Peter J Campbell

31

1 reference

29 June 2018

language of work or name

English

0 references

publication date

13 March 2017

1 reference

29 June 2018

published in

Nature Medicine

1 reference

29 June 2018

volume

23

1 reference

29 June 2018

issue

4

1 reference

29 June 2018

page(s)

517-525

1 reference

29 June 2018

The topography of mutational processes in breast cancer genomes

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Genomic analyses identify molecular subtypes of pancreatic cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Clock-like mutational processes in human somatic cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

A mutational signature in gastric cancer suggests therapeutic strategies

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Whole genomes redefine the mutational landscape of pancreatic cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients--a study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD).

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Two decades after BRCA: setting paradigms in personalized cancer care and prevention

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Genome-wide transcriptome profiling of homologous recombination DNA repair

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Signatures of mutational processes in human cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Classifications within molecular subtypes enables identification of BRCA1/BRCA2 mutation carriers by RNA tumor profiling

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Deciphering signatures of mutational processes operative in human cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Mutational processes molding the genomes of 21 breast cancers

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

The life history of 21 breast cancers

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

The DNA damage response and cancer therapy

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Genomic and phenotypic analysis of BRCA2 mutated breast cancers reveals co-occurring changes linked to progression

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Allele-specific copy number analysis of tumors

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Fast and accurate short read alignment with Burrows-Wheeler transform

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Accurate whole human genome sequencing using reversible terminator chemistry

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Velvet: algorithms for de novo short read assembly using de Bruijn graphs

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Resistance to therapy caused by intragenic deletion in BRCA2

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Whole-genome characterization of chemoresistant ovarian cancer.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

"The race" to clone BRCA1.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

DNA repair signature is associated with anthracycline response in triple negative breast cancer patients

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

A significant response to neoadjuvant chemotherapy in BRCA1/2 related breast cancer

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Prevalence and Predictors ofBRCA1andBRCA2Mutations in a Population-Based Study of Breast Cancer in White and Black American Women Ages 35 to 64 Years

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5833945

Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Anglian Breast Cancer Study Group

1 December 2018

1 reference

7 January 2021

Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers

1 reference

7 January 2021

Prediction of BRCA1-association in hereditary non-BRCA1/2 breast carcinomas with array-CGH

1 reference

7 January 2021

Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM.4292

1 reference

29 June 2018

PMC publication ID

5833945

1 reference

29 June 2018

PubMed publication ID

28288110

1 reference

29 June 2018