(Q48252631)

10 February 2018

title

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases (English)

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10 February 2018

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Kunikazu Tanji

1

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10 February 2018

Atsushi Maruyama

2

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10 February 2018

Saori Odagiri

3

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10 February 2018

Fumiaki Mori

4

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10 February 2018

Ken Itoh

5

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10 February 2018

Akiyoshi Kakita

6

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10 February 2018

Hitoshi Takahashi

7

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10 February 2018

Koichi Wakabayashi

8

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10 February 2018

publication date

1 January 2013

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10 February 2018

Journal of Neuropathology & Experimental Neurology

published in

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10 February 2018

volume

72

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10 February 2018

issue

1

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10 February 2018

page(s)

18-28

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10 February 2018

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

cites work

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Nrf2-Keap1 defines a physiologically important stress response mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Subcellular localization and cytoplasmic complex status of endogenous Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Keap1 degradation by autophagy for the maintenance of redox homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Selective autophagy mediated by autophagic adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Expression of Nrf2 in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Neurodegenerative diseases and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Oxidative stress in ALS: key role in motor neuron injury and therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Zinc induces depletion and aggregation of endogenous TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E31827B5713

10.1097/NEN.0B013E31827B5713

21 January 2018

Identifiers

DOI

1 reference

10 February 2018

1 reference

10 February 2018