(Q48299636)

10 February 2018

http://europepmc.org/abstract/MED/28133950

title

Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides (English)

1 reference

10 February 2018

http://europepmc.org/abstract/MED/28133950

main subject

UFKHAWLCPNOJCK-CMNRWXDESA-N

1 reference

inferred from

reverse claim

(14S,15S,16S,17R,29S,30R,33R,35S,37S,41R,43S,45R,47S,51S,55R)-58-amino-15,17,29,33,35,37,41,43,45,47,51,55-dodecahydroxy-14,16,30-trimethyl-31-oxooctapentaconta-2,4,6,8,12,18,20,22,24,26,38,48,52-tridecaenoic acid

1 reference

inferred from

reverse claim

(16S,17S,18S,19R,31S,32R,35R,37S,41R,43S,47R,49S,53S,55R,57S,61R)-64-amino-17,19,31,35,37,41,43,47,49,53,55,61-dodecahydroxy-4,16,18,32,57-pentamethyl-33-oxotetrahexaconta-2,4,6,8,10,14,20,22,24,26,28,38,50,58-tetradecaenoic acid

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28133950%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Bin Qin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28133950%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Kazuo Shin-ya

16

1 reference

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10 June 2020

Ikuro Abe

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28133950%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

12

Shunji Takahashi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28133950%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Takuya Hashimoto

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28133950%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Junko Hashimoto

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28133950%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ikuko Kozone

5

1 reference

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10 June 2020

Teppei Kawahara

6

1 reference

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10 June 2020

Masahiro Okada

7

1 reference

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10 June 2020

Takayoshi Awakawa

8

1 reference

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10 June 2020

Takuya Ito

9

1 reference

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10 June 2020

Yoshinori Asakawa

10

1 reference

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10 June 2020

Masashi Ueki

11

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10 June 2020

Hiroyuki Osada

13

1 reference

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10 June 2020

Toshiyuki Wakimoto

14

1 reference

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10 June 2020

Haruo Ikeda

15

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10 June 2020

language of work or name

English

0 references

publication date

11 January 2017

1 reference

10 February 2018

http://europepmc.org/abstract/MED/28133950

published in

Angewandte Chemie International Edition

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28133950%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

56

1 reference

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10 June 2020

issue

7

1 reference

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10 June 2020

page(s)

1740-1745

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Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

10 June 2020

cites work

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The biosynthetic logic of polyketide diversity

21 January 2018

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Strategies for the discovery of new natural products by genome mining

21 January 2018

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Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology

21 January 2018

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Harnessing the Biosynthetic Potential of Modular Polyketide Synthases

21 January 2018

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Combinatorial approaches to polyketide biosynthesis

21 January 2018

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Molecular engineering approaches to peptide, polyketide and other antibiotics

21 January 2018

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Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation

21 January 2018

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Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology

21 January 2018

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Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases

21 January 2018

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Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

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Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis

21 January 2018

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Evolution of polyketide synthases in bacteria

21 January 2018

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A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis

21 January 2018

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Synthetic biology to access and expand nature's chemical diversity

21 January 2018

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A common origin for guanidinobutanoate starter units in antifungal natural products

21 January 2018

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An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics

21 January 2018

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Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

21 January 2018

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Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

21 January 2018

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Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites

21 January 2018

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Stereocontrol within polyketide assembly lines

21 January 2018

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A tylosin ketoreductase reveals how chirality is determined in polyketides

21 January 2018

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Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

21 January 2018

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Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation

21 January 2018

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Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

21 January 2018

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Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

21 January 2018

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Desertomycin, a New Crystalline Antibiotic with Antibacterial and Cytostatic Action

21 January 2018

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Polyene Antibiotics fromStreptomyces mediocidicus

21 January 2018

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9 March 2024

https://opencitations.net/index/api/v1/references/10.1002/ANIE.201611371

Tetrafibricin, a novel fibrinogen receptor antagonist. II. Structural elucidation

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9 March 2024

https://opencitations.net/index/api/v1/references/10.1002/ANIE.201611371

The structure of lienomycin, a pentaene macrolide antitumor antibiotic. II. The location of the pentaene chromophore and of six isolated double bonds. The complete structure of the antibiotic

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9 March 2024

https://opencitations.net/index/api/v1/references/10.1002/ANIE.201611371

Die biosynthetische Grundlage der Polyketid-Vielfalt

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9 March 2024

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Pironetin, a Novel Plant Growth Regulator Produced by Streptomyces sp. NK10958 III. Biosynthesis.

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9 March 2024

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Comprehensive in Vitro Analysis of Acyltransferase Domain Exchanges in Modular Polyketide Synthases and Its Application for Short-Chain Ketone Production.

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9 March 2024

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Clethramycin, a new inhibitor of pollen tube growth with antifungal activity from Streptomyces hygroscopicus TP-A0623. II. Physico-chemical properties and structure determination

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9 March 2024

https://opencitations.net/index/api/v1/references/10.1002/ANIE.201611371

Complete stereochemistry of tetrafibricin

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9 March 2024

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Linearmycin A, a novel linear polyene antibiotic

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9 March 2024

https://opencitations.net/index/api/v1/references/10.1002/ANIE.201611371

Identifiers

DOI

10.1002/ANIE.201611371

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28133950%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference