(Q38629855)

4 September 2017

title

Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology (English)

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4 September 2017

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Kira J Weissman

1

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4 September 2017

publication date

10 November 2015

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4 September 2017

published in

Natural Product Reports

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4 September 2017

volume

33

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4 September 2017

issue

2

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4 September 2017

page(s)

203-230

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Natural product and natural product derived drugs in clinical trials.

4 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Discovering new bioactive molecules from microbial sources.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Modular organization of genes required for complex polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A tylosin ketoreductase reveals how chirality is determined in polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A Bacillus subtilis large ORF coding for a polypeptide highly similar to polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Biosynthesis of polyketides by trans-AT polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A multifunctional polyketide-peptide synthetase essential for albicidin biosynthesis in Xanthomonas albilineans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Computational identification and analysis of orphan assembly-line polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Isoprenoid-like alkylations in polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Evolutionary implications of bacterial polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Combinatorial approaches to polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Combinatorial biosynthesis of reduced polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Progress challenges and opportunities for the re-engineering of trans-AT polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Mutasynthesis - uniting chemistry and genetics for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Biological variation of microbial metabolites by precursor-directed biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Bacteriophage recombination systems and biotechnical applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A new enzyme superfamily - the phosphopantetheinyl transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A new logic for DNA engineering using recombination in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Expanding the Biologist's Toolkit with CRISPR-Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

CRISPR-Cas9-assisted recombineering in Lactobacillus reuteri

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

CRISPR-Cas9 Based Engineering of Actinomycetal Genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Methods and options for the heterologous production of complex natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Production of the potent antibacterial polyketide erythromycin C in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Engineered polyketide biosynthesis and biocatalysis in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Approaches to capturing and designing biologically active small molecules produced by uncultured microbes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A multiplasmid approach to preparing large libraries of polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Enzymatic assembly of DNA molecules up to several hundred kilobases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A one pot, one step, precision cloning method with high throughput capability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Steps towards the synthetic biology of polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Merging chemical synthesis and biosynthesis: a new chapter in the total synthesis of natural products and natural product libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

An erythromycin analog produced by reprogramming of polyketide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Active-site residue, domain and module swaps in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Insights into the stereospecificity of ketoreduction in a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Divergence of multimodular polyketide synthases revealed by a didomain structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A polylinker approach to reductive loop swaps in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

The biochemical basis for stereochemical control in polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Engineering the acyltransferase substrate specificity of assembly line polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Origin of starter units for erythromycin biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Intermediates released from a polyether-producing polyketide synthase provide insight into the mechanism of oxidative cyclization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Engineering broader specificity into an antibiotic-producing polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Engineering of the spinosyn PKS: directing starter unit incorporation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Production of a novel polyketide through the construction of a hybrid polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Doramectin--a potent novel endectocide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Production of doramectin by rational engineering of the avermectin biosynthetic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

The structure of docking domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Freedom and constraint in engineered noncolinear polyketide assembly lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Multifactorial control of iteration events in a modular polyketide assembly line

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

DKxanthene biosynthesis--understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Biosynthesis of crocacin involves an unusual hydrolytic release domain showing similarity to condensation domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

The structural basis for docking in modular polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

The origins of specificity in polyketide synthase protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Multienzyme docking in hybrid megasynthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Structure of a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

The Lego-ization of polyketide biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Rational design and assembly of synthetic trimodular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Structural rearrangements of a polyketide synthase module during its catalytic cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Metamorphic enzyme assembly in polyketide diversification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

An enzymatic domain for the formation of cyclic ethers in complex polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Poly specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Establishing a toolkit for precursor-directed polyketide biosynthesis: exploring substrate promiscuities of acid-CoA ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A hybrid non-ribosomal peptide/polyketide synthetase containing fatty-acyl ligase (FAAL) synthesizes the β-amino fatty acid lipopeptides puwainaphycins in the Cyanobacterium Cylindrospermum alatosporum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00109A

A Novel Erythromycin, 6-Desmethyl Erythromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase

21 January 2018

1 reference

COCI

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.56.543

Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity

12 April 2024

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.51.1029

Identifiers

DOI

10.1039/C5NP00109A

1 reference

4 September 2017

1 reference