(Q48696412)

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Expression Pattern of Scavenger Receptors and Amyloid-β Phagocytosis of Astrocytes and Microglia in Culture are Modified by Acidosis: Implications for Alzheimer's Disease.

scientific article published on 30 May 2016

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3 April 2020

Expression Pattern of Scavenger Receptors and Amyloid-β Phagocytosis of Astrocytes and Microglia in Culture are Modified by Acidosis: Implications for Alzheimer's Disease (English)

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3 April 2020

Alzheimer's disease

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Francisca Cornejo

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3 April 2020

Rommy von Bernhardi

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Jaime Eugenín

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3 April 2020

Andrea Vecchiola

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Paola Murgas

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Pablo Arroyo

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1 May 2016

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3 April 2020

Journal of Alzheimer's Disease

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857-873

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3 April 2020

Pathways towards and away from Alzheimer's disease

1 reference

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Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease

1 reference

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Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice.

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Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology

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Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

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Neurovascular regulation in the normal brain and in Alzheimer's disease

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Cerebrovascular damage as a cause for Alzheimer's disease

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Hypothesis on the relationship between the change in intracellular pH and incidence of sporadic Alzheimer's disease or vascular dementia.

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Effects of acidosis on the distribution of processing of the beta-amyloid precursor protein in cultured hippocampal neurons.

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

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Quantification and distribution of beta-secretase alternative splice variants in the rat and human brain

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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Lactic acid induces aberrant amyloid precursor protein processing by promoting its interaction with endoplasmic reticulum chaperone proteins

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

1 reference

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21 January 2018

Acidic pH promotes the formation of toxic fibrils from beta-amyloid peptide

1 reference

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21 January 2018

Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.

1 reference

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21 January 2018

Biochemical studies of nerve cells and energy metabolism in Alzheimer's disease

1 reference

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21 January 2018

Reduction of beta-amyloid-induced neurotoxicity on hippocampal cell cultures by moderate acidosis is mediated by transforming growth factor beta.

1 reference

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21 January 2018

The role of Na(+)/h (+) exchanger isoform 1 in inflammatory responses: maintaining H(+) homeostasis of immune cells

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21 January 2018

Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis

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21 January 2018

Physiology of microglia

1 reference

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Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain

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21 January 2018

Intracellular pH as a regulatory signal in astrocyte metabolism

1 reference

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21 January 2018

TRP channels are involved in mediating hypercapnic Ca2+ responses in rat glia-rich medullary cultures independent of extracellular pH.

1 reference

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21 January 2018

Astrocytes control breathing through pH-dependent release of ATP

1 reference

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21 January 2018

Voltage-gated proton channel HV1 in microglia.

1 reference

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21 January 2018

Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes

1 reference

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21 January 2018

Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism

1 reference

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21 January 2018

CO₂directly modulates connexin 26 by formation of carbamate bridges between subunits

1 reference

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21 January 2018

Glial cell dysregulation: a new perspective on Alzheimer disease

1 reference

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21 January 2018

The role of apolipoprotein E in Alzheimer's disease

1 reference

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21 January 2018

The mechanism of memory impairment induced by Aβ chronic administration involves imbalance between cytokines and neurotrophins in the rat hippocampus

1 reference

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21 January 2018

Cytokines, chemokines, and cytokine receptors in human microglia

1 reference

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21 January 2018

Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro.

1 reference

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21 January 2018

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

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21 January 2018

Microglial cell dysregulation in brain aging and neurodegeneration

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21 January 2018

Protection of rat primary hippocampal cultures from A beta cytotoxicity by pro-inflammatory molecules is mediated by astrocytes.

1 reference

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21 January 2018

The microglial "activation" continuum: from innate to adaptive responses

1 reference

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21 January 2018

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

1 reference

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21 January 2018

NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease

1 reference

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21 January 2018

Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid

1 reference

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21 January 2018

Age-dependent changes on TGFβ1 Smad3 pathway modify the pattern of microglial cell activation

1 reference

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21 January 2018

Inflammation and Alzheimer's disease

1 reference

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21 January 2018

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

1 reference

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21 January 2018

Role of scavenger receptors in glia-mediated neuroinflammatory response associated with Alzheimer's disease.

1 reference

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21 January 2018

Aβ potentiates inflammatory activation of glial cells induced by scavenger receptor ligands and inflammatory mediators in culture.

1 reference

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21 January 2018

Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages

1 reference

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21 January 2018

Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system

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21 January 2018

CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils

1 reference

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21 January 2018

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

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21 January 2018

Neurovascular mechanisms of Alzheimer's neurodegeneration

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21 January 2018

Neurovascular unit dysfunction: a vascular component of Alzheimer disease?

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Important aspects of Toll-like receptors, ligands and their signaling pathways

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21 January 2018

SR-A regulates the inflammatory activation of astrocytes

1 reference

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Alzheimer's Disease

1 reference

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21 January 2018

Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q.

1 reference

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21 January 2018

Transforming growth factor-beta 1 produced by hippocampal cells modulates microglial reactivity in culture.

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21 January 2018

Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.

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21 January 2018

Mechanisms underlying inflammation in neurodegeneration

1 reference

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21 January 2018

Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia.

1 reference

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21 January 2018

Type 2 diabetes as a risk factor for Alzheimer's disease: the confounders, interactions, and neuropathology associated with this relationship

1 reference

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21 January 2018

Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer's disease

1 reference

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21 January 2018

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1 reference

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21 January 2018

Diabetic ketoacidosis in juvenile rats is associated with reactive gliosis and activation of microglia in the hippocampus

1 reference

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21 January 2018

Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats

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21 January 2018

Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases.

1 reference

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21 January 2018

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1 reference

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21 January 2018

Effect of different degrees of brain ischemia and tissue lactic acidosis on the short-term recovery of neurophysiologic and metabolic variables.

1 reference

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21 January 2018

Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease

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21 January 2018

Beta-amyloid expression, release and extracellular deposition in aged rat brain slices

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21 January 2018

Role of hyperglycaemia-related acidosis in ischaemic brain damage

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21 January 2018

Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo.

1 reference

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21 January 2018

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.

1 reference

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21 January 2018

Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

1 reference

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21 January 2018

Astrocytes are active players in cerebral innate immunity

1 reference

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21 January 2018

Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture

1 reference

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21 January 2018

Changes in macrophage function modulated by the lipid environment

1 reference

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21 January 2018

Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke

1 reference

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21 January 2018

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1 reference

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21 January 2018

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21 January 2018

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Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways

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21 January 2018

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1 reference

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21 January 2018

The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia.

1 reference

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21 January 2018

Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

1 reference

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21 January 2018

Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid

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Expression of macrophage MARCO receptor induces formation of dendritic plasma membrane processes

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21 January 2018

Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease

1 reference

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21 January 2018

Scavenger receptor mRNAs in rat brain microglia are induced by kainic acid lesioning and by cytokines

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21 January 2018

Identifiers

10.3233/JAD-160083

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27258416%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27258416%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

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