(Q48762970)

15 February 2018

title

Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease. (English)

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15 February 2018

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9

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15 February 2018

Reinald Pamplona

10

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15 February 2018

Ester Aso

Ester Aso

1

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Mario Diaz

Mario Díaz

13

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Isidro Ferrer

14

Isidro Ferrer

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15 February 2018

Margarita Enid Ramírez Carmona

5

Margarita Carmona

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15 February 2018

Manuel Portero-Otin

11

Manuel Portero-Otin

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15 February 2018

author name string

Selene Lomoio

2

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15 February 2018

Irene López-González

3

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15 February 2018

Laura Joda

4

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15 February 2018

Núria Fernández-Yagüe

6

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15 February 2018

Jesús Moreno

7

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15 February 2018

Salvador Juvés

8

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15 February 2018

Virginia Martín

12

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15 February 2018

publication date

13 January 2012

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15 February 2018

published in

Brain Pathology

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15 February 2018

volume

22

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15 February 2018

issue

5

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15 February 2018

page(s)

636-653

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15 February 2018

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

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Current status on Alzheimer disease molecular genetics: from past, to present, to future

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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21 January 2018

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Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease

21 January 2018

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Widespread axonal damage in the brain of drug abusers as evidenced by accumulation of beta-amyloid precursor protein (beta-APP): an immunohistochemical investigation.

21 January 2018

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β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation

21 January 2018

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Oxidative inactivation of the proteasome in Alzheimer's disease.

21 January 2018

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Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred

21 January 2018

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Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice.

21 January 2018

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Dystrophic neurites of senile plaques are defective in proteins involved in exocytosis and neurotransmission.

21 January 2018

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Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

21 January 2018

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Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies

21 January 2018

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Beta-secretase activity increases with aging in human, monkey, and mouse brain.

21 January 2018

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

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The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders

21 January 2018

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21 January 2018

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Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

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Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

21 January 2018

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Mechanisms of tau-induced neurodegeneration

21 January 2018

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Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

21 January 2018

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ALZHEIMER'S DISEASE--AN ELECTRON MICROSCOPICAL STUDY

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Brain Cytochrome Oxidase in Alzheimer's Disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Core proteins of the secretory machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Molecular dissection of the 11S REG (PA28) proteasome activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Aggregation state and neurotoxic properties of alzheimer β-amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Alzheimer's disease: a lesson from mitochondrial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Characterization of the brain β-amyloid isoform pattern at different ages of Tg2576 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

The ubiquitin-proteasome system in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Dystrophic neurites of senile plaques in Alzheimer's disease are deficient in cytochrome c oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Association of a presenilin 1 S170F mutation with a novel Alzheimer disease molecular phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Functional implications of the association of tau with the plasma membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Role of protein phosphatase 2A in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

The catalytic core of gamma-secretase: presenilin revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Abeta inhibits the proteasome and enhances amyloid and tau accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Beta-secretase: structure, function, and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

The 26S proteasome: a molecular machine designed for controlled proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Energetics, epigenetics, mitochondrial genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

A beta oligomers - a decade of discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.2011.00560.X

10.1111/J.1750-3639.2011.00560.X

21 January 2018

Identifiers

DOI

1 reference

15 February 2018

1 reference

15 February 2018