(Q50918265)

25 March 2018

title

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase. (English)

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25 March 2018

main subject

TSC1-TSC2 complex

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Gene Ontology release 2020-05-02

Masahiro Uritani

1

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25 March 2018

Hidetoshi Hidaka

2

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25 March 2018

Yukari Hotta

3

1 reference

25 March 2018

Masaru Ueno

4

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25 March 2018

Takashi Ushimaru

5

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25 March 2018

Takashi Toda

6

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25 March 2018

publication date

1 December 2006

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25 March 2018

published in

Genes to Cells

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25 March 2018

volume

11

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25 March 2018

issue

12

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25 March 2018

page(s)

1367-1379

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25 March 2018

Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

FAT: a novel domain in PIK-related kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Gene ste20 controls amiloride sensitivity and fertility in Schizosaccharomyces pombe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Tor signalling in bugs, brain and brawn

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

A wat1 mutant of fission yeast is defective in cell morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

HEAT repeats mediate plasma membrane localization of Tor2p in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

The expanding TOR signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

A starvation-specific serine protease gene, isp6 +, is involved in both autophagy and sexual development in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

The ATRs, ATMs, and TORs are giant HEAT repeat proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2443.2006.01025.X

10.1111/J.1365-2443.2006.01025.X

21 January 2018

Identifiers

DOI

1 reference

25 March 2018

PubMed ID

17121544

1 reference

25 March 2018