(Q51686167)

9 April 2018

title

A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility. (English)

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9 April 2018

2

Jirina Bartkova

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9 April 2018

7

Jiri Bartek

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9 April 2018

Claus Christensen

1

1 reference

9 April 2018

Martin Mistrík

3

1 reference

9 April 2018

Arnaldur Hall

4

1 reference

9 April 2018

Marina Krarup Lange

5

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9 April 2018

Ulrik Ralfkiær

6

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9 April 2018

Per Guldberg

8

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9 April 2018

language of work or name

English

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publication date

5 November 2014

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9 April 2018

published in

Nature Communications

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9 April 2018

volume

5

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9 April 2018

page(s)

5348

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9 April 2018

https://scigraph.springernature.com/pub.10.1038/ncomms6348

exact match

0 references

cites work

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Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

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Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells

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INK4a/ARF: a multifunctional tumor suppressor locus

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p53-independent functions of the p19(ARF) tumor suppressor

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Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis

21 January 2018

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p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways

21 January 2018

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

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Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death

21 January 2018

1 reference

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p53-Dependent and p53-independent activation of autophagy by ARF

21 January 2018

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Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

21 January 2018

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Germline p16 mutations in familial melanoma

21 January 2018

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High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL

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Genetic risk factors for melanoma

21 January 2018

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A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6348

A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.

21 January 2018

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Melanoma risk for CDKN2A mutation carriers who are relatives of population-based case carriers in Australia and the UK

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6348

Geographical variation in the penetrance of CDKN2A mutations for melanoma

21 January 2018

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The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study

21 January 2018

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

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Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.

21 January 2018

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Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein

21 January 2018

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The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6348

ARF induces autophagy by virtue of interaction with Bcl-xl.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6348

Telomere dysfunction induces metabolic and mitochondrial compromise.

21 January 2018

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6348

Mitochondria, oxidants, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6348

Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.

21 January 2018

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p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

21 January 2018

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6348

The p16(INK4A) tumor suppressor regulates cellular oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Mitochondrial p32 is a critical mediator of ARF-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Cancer and ageing: rival demons?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

ARF in the mitochondria: the last frontier?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Signatures of mutational processes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

A comprehensive catalogue of somatic mutations from a human cancer genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V 600 E) B-RAF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARβ signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Germline mutation of ARF in a melanoma kindred

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

inferred from DOI database lookup

7 January 2021

based on heuristic

Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

inferred from DOI database lookup

7 January 2021

based on heuristic

The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6348

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS6348

1 reference

9 April 2018

ADS bibcode

2014NatCo...5.5348C

0 references

1 reference

9 April 2018