(Q52840129)

8 May 2018

title

Projection of exposure and efficacious dose prior to first-in-human studies: how successful have we been? (English)

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8 May 2018

author name string

Christine Huang

1

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8 May 2018

Ming Zheng

2

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8 May 2018

Zheng Yang

3

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8 May 2018

A David Rodrigues

4

1 reference

8 May 2018

Punit Marathe

5

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8 May 2018

publication date

25 September 2007

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8 May 2018

published in

Pharmaceutical Research

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8 May 2018

volume

25

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8 May 2018

issue

4

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8 May 2018

page(s)

713-726

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8 May 2018

Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?

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In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

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Interspecies pharmacokinetic scaling and the Dedrick plots

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12 December 2020

10.1007/S11095-007-9411-4

Identifiers

DOI

1 reference

8 May 2018

1 reference

8 May 2018