(Q53483899)

English

Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.

scientific article published in April 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Euphorbia peplus

1 reference

Ingenol-3-angelate

1 reference

Sandrine Faivre

4

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Steven M Ogbourne

object named as

Steven M Ogbourne

9

0 references

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Janet Lord

8

0 references

author name string

Maria Serova

1

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Aïda Ghoul

2

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Karim A Benhadji

3

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Christophe Le Tourneau

5

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Esteban Cvitkovic

6

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Francois Lokiec

7

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Fabien Calvo

10

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

Eric Raymond

11

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

publication date

1 April 2008

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

full work available at URL

https://aacrjournals.org/mct/article-pdf/7/4/915/1879696/915.pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1158/1535-7163.mct-07-2060?email=unpaywall_01@example.com

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

7

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

4

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

915-922

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

online access status

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1158/1535-7163.mct-07-2060?email=unpaywall_01@example.com

access restriction status

1 reference

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MAP kinase signalling pathways in cancer

1 reference

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Ceramide inactivates cellular protein kinase Calpha

1 reference

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Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

1 reference

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Identification of PKC-isoform-specific biological actions using pharmacological approaches

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Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms

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A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

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PKC-δ is an apoptotic lamin kinase

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Protein kinase C: structure, function, and regulation

1 reference

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Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death

1 reference

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Characterization of the interaction of ingenol 3-angelate with protein kinase C.

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Caspases: enemies within

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Caspase‐3 dependent proteolytic activation of protein kinase Cδ mediates and regulates 1‐methyl‐4‐phenylpyridinium (MPP+)‐induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration

1 reference

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Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

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Activation of PKC is sufficient to induce an apoptotic program in salivary gland acinar cells

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A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis

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Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression

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Protein kinase C isozymes as potential targets for anticancer therapy

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Involvement of protein kinase C, p38 MAP kinase and ERK in arachidonic acid-stimulated superoxide production in human neutrophils

1 reference

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HOME TREATMENT OF SKIN CANCER AND SOLAR KERATOSES

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Proceedings of the First International Conference on PEP005.

1 reference

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Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205.

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

1 reference

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PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.

2 references

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Protein kinase C inhibitors as novel anticancer drugs

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Regulation of Raf-1 activation and signalling by dephosphorylation

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Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta

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Signal perception and transduction: the role of protein kinases

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The catalytic domain of protein kinase Cdelta confers protection from down-regulation induced by bryostatin 1.

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Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway.

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A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate

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Identifiers

10.1158/1535-7163.MCT-07-2060

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18413805

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