(Q54631286)

1 June 2018

title

Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907. (English)

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8

Hans-Ulrich Häring

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10

Cora Weigert

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Erwin Schleicher

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object named as

Erwin D Schleicher

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1 June 2018

author name string

Louise Fritsche

1

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Sabine S Neukamm

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Rainer Lehmann

3

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Elisabeth Kremmer

4

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Anita M Hennige

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Andrea Hunder-Gugel

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Martin Schenk

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publication date

23 November 2010

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American Journal of Physiology - Endocrinology and Metabolism

published in

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volume

300

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issue

5

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page(s)

E824-36

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

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Phosphorylation of IRS proteins, insulin action, and insulin resistance

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Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

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siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

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Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation

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Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.

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Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

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A quantitative atlas of mitotic phosphorylation

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Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth

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Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

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MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632

21 January 2018

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The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis

21 January 2018

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Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress

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The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.

21 January 2018

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Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

21 January 2018

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

21 January 2018

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Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

21 January 2018

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Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

21 January 2018

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Prevention of fat-induced insulin resistance by salicylate

21 January 2018

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O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs

21 January 2018

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Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding

21 January 2018

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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

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Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.

21 January 2018

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Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling

21 January 2018

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Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle

21 January 2018

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IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

21 January 2018

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Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

21 January 2018

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Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

21 January 2018

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Identification, analysis, and prediction of protein ubiquitination sites

21 January 2018

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Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules

21 January 2018

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Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

21 January 2018

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

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Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

21 January 2018

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Chapter 4 Preparation of Isolated Rat Liver Cells

21 January 2018

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Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis

21 January 2018

1 reference

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Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

21 January 2018

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The function of GRB2 in linking the insulin receptor to Ras signaling pathways

21 January 2018

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Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

21 January 2018

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Role of IRS-2 in insulin and cytokine signalling

21 January 2018

1 reference

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Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

21 January 2018

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

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Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

21 January 2018

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Critical nodes in signalling pathways: insights into insulin action

21 January 2018

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Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver

21 January 2018

1 reference

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Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

21 January 2018

1 reference

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Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

21 January 2018

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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells

21 January 2018

1 reference

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Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00409.2010

10.1152/AJPENDO.00409.2010

21 January 2018

Identifiers

DOI

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