(Q54738945)

3 June 2018

title

Cell cycle activation and CNS injury. (English)

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3 June 2018

author

Kimberly R. Byrnes

series ordinal

2

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3 June 2018

Bogdan A Stoica

object named as

Bogdan A Stoica

series ordinal

1

0 references

author name string

Alan I Faden

series ordinal

3

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3 June 2018

publication date

21 April 2009

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3 June 2018

published in

Neurotoxicity Research

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3 June 2018

volume

16

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3 June 2018

issue

3

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3 June 2018

page(s)

221-237

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3 June 2018

Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity

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The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death.

21 January 2018

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Cell cycle molecules define a pathway required for neuron death in development and disease

21 January 2018

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Altered distribution of cell cycle transcriptional regulators during Alzheimer disease.

21 January 2018

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Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene.

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12640-009-9050-0

The Microglial Reaction in the Rat Dorsal Hippocampus following Transient Forebrain Ischemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12640-009-9050-0

Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9050-0

Cell cycle machinery and stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9050-0

Chemistry and biochemistry of oxidative stress in neurodegenerative disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12640-009-9050-0

Cell cycle activation in postmitotic neurons is essential for DNA repair.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12640-009-9050-0

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12640-009-9050-0

Cell division in the CNS: protective response or lethal event in post-mitotic neurons?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12640-009-9050-0

Cdk5 and the non-catalytic arrest of the neuronal cell cycle

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12640-009-9050-0

Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease.

21 January 2018

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12 December 2020

The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.

1 reference

12 December 2020

Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity

1 reference

12 December 2020

Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia.

1 reference

12 December 2020

Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1.

1 reference

12 December 2020

Cell death: the significance of apoptosis

1 reference

12 December 2020

Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity

1 reference

12 December 2020

Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo

1 reference

12 December 2020

DNA damage response and neuroprotection

1 reference

12 December 2020

Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation

1 reference

12 December 2020

Alzheimer Disease in the US Population

1 reference

12 December 2020

Gene profiling in spinal cord injury shows role of cell cycle in neuronal death

1 reference

12 December 2020

Effects of Alzheimer's disease on different cortical layers: the role of intrinsic differences in Abeta susceptibility.

1 reference

12 December 2020

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1 reference

12 December 2020

Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene

1 reference

12 December 2020

Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription

1 reference

12 December 2020

RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis.

1 reference

12 December 2020

Efficient three-drug cocktail for disease induced by mutant superoxide dismutase

1 reference

12 December 2020

B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage

1 reference

12 December 2020

Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons

1 reference

12 December 2020

Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes

1 reference

12 December 2020

Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons

1 reference

12 December 2020

The induction of multiple cell cycle events precedes target-related neuronal death

1 reference

12 December 2020

Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease

1 reference

12 December 2020

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

1 reference

12 December 2020

Direct coupling of the cell cycle and cell death machinery by E2F.

1 reference

12 December 2020

Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia.

1 reference

12 December 2020

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression

1 reference

12 December 2020

A matter of life and cell death

1 reference

12 December 2020

Pro-apoptotic Bim Induction in Response to Nerve Growth Factor Deprivation Requires Simultaneous Activation of Three Different Death Signaling Pathways

1 reference

12 December 2020

Aging, mild cognitive impairment, and Alzheimer's disease

1 reference

12 December 2020

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

1 reference

12 December 2020

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease

1 reference

12 December 2020

Constitutive expression of functionally active cyclin-dependent kinases and their binding partners suggests noncanonical functions of cell cycle regulators in differentiated neurons

1 reference

12 December 2020

Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain

1 reference

12 December 2020

Death by suicide: one way to go in mammalian cellular development?

1 reference

12 December 2020

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

1 reference

12 December 2020

The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease

1 reference

12 December 2020

Cellular response to oxidative stress: signaling for suicide and survival

1 reference

12 December 2020

The p53-independent nuclear translocation of cyclin G1 in degenerating neurons by ischemic and traumatic insults

1 reference

12 December 2020

Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta

1 reference

12 December 2020

The mouse interferon-gamma transgene chronic hepatitis model (Review).

1 reference

12 December 2020

1 reference

12 December 2020

Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

1 reference

12 December 2020

Roscovitine targets, protein kinases and pyridoxal kinase

1 reference

12 December 2020

Microglia in health and disease

1 reference

12 December 2020

Complexities in the development of cyclin-dependent kinase inhibitor drugs

1 reference

12 December 2020

The inflammatory response in stroke

1 reference

12 December 2020

DNA strand breaks in Alzheimer's disease.

1 reference

12 December 2020

The fidelity of DNA polymerase beta during distributive and processive DNA synthesis

1 reference

12 December 2020

Role of cell cycle proteins in CNS injury

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12 December 2020

Regeneration beyond the glial scar

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12 December 2020

Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle

1 reference

12 December 2020

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.

1 reference

12 December 2020

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

1 reference

12 December 2020

Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease

1 reference

12 December 2020

Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons

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12 December 2020

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions

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12 December 2020

Aneuploidy in the normal and diseased brain.

1 reference

12 December 2020

Pathological proteins in senile plaques.

1 reference

12 December 2020

The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons.

1 reference

12 December 2020

Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage

1 reference

12 December 2020

Activation of cyclin A-dependent protein kinases during apoptosis

1 reference

12 December 2020

Divide and die: cell cycle events as triggers of nerve cell death.

1 reference

12 December 2020

Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

1 reference

12 December 2020

Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina.

1 reference

12 December 2020

Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain

1 reference

12 December 2020

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

1 reference

12 December 2020

Inflammation-induced GDNF improves locomotor function after spinal cord injury

1 reference

12 December 2020

Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid

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12 December 2020

Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death.

1 reference

12 December 2020

Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entry

1 reference

12 December 2020

Downregulation of CDC2 upon terminal differentiation of neurons

1 reference

12 December 2020

Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model

1 reference

12 December 2020

Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury.

1 reference

12 December 2020

Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation

1 reference

12 December 2020

Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat

1 reference

12 December 2020

Cell cycle molecules and vertebrate neuron death: E2F at the hub.

1 reference

12 December 2020

Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism.

1 reference

12 December 2020

Cyclin D1 and Cdk4 protein induction in motor neurons after transient spinal cord ischemia in rabbits

1 reference

12 December 2020

Increased nuclear DNA oxidation in the brain in Alzheimer's disease

1 reference

12 December 2020

Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury

1 reference

12 December 2020

Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats

1 reference

12 December 2020

E2F1 works as a cell cycle suppressor in mature neurons

1 reference

12 December 2020

1 reference

12 December 2020

Integrins mediate beta-amyloid-induced cell-cycle activation and neuronal death.

1 reference

12 December 2020

Linking DNA damage and neurodegeneration

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12 December 2020

Why do neurons enter the cell cycle?

1 reference

12 December 2020

Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

1 reference

12 December 2020

Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice

1 reference

12 December 2020

Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma

1 reference

12 December 2020

Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration

1 reference

12 December 2020

Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.

1 reference

12 December 2020

1 reference

12 December 2020

On the nature of a defect in cells from individuals with ataxia-telangiectasia

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12 December 2020

Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration

1 reference

12 December 2020

Neuroprotection and traumatic brain injury: theoretical option or realistic proposition

1 reference

12 December 2020

Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.

1 reference

12 December 2020

Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease

1 reference

12 December 2020

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death.

1 reference

12 December 2020

Transgenic mouse models of Alzheimer's disease

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12 December 2020

Increased expression of cyclin G1 and p21WAF1/CIP1 in neurons following transient forebrain ischemia: comparison with early DNA damage

1 reference

12 December 2020

Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats

1 reference

12 December 2020

Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes

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12 December 2020

Alzheimer's disease research enters a "new cycle": how significant?

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12 December 2020

DNA replication precedes neuronal cell death in Alzheimer's disease.

1 reference

12 December 2020

Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment.

1 reference

12 December 2020

Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

1 reference

12 December 2020

Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice

1 reference

12 December 2020

The genetics of the E2F family of transcription factors: shared functions and unique roles

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12 December 2020

Apoptosis in neurodegenerative disorders

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12 December 2020

Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death

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12 December 2020

Alzheimer's disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain

1 reference

12 December 2020

E2F1 induces cell death, calpain activation, and MDMX degradation in a transcription independent manner implicating a novel role for E2F1 in neuronal loss in SIV encephalitis

1 reference

12 December 2020

CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage.

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12 December 2020

Cell cycle activation linked to neuronal cell death initiated by DNA damage

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12 December 2020

Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons

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12 December 2020

Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration

1 reference

12 December 2020

E2F-1 and a cyclin-like DNA repair enzyme, uracil-DNA glycosylase, provide evidence for an autoregulatory mechanism for transcription

1 reference

12 December 2020

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1 reference

12 December 2020

The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

1 reference

12 December 2020

Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo.

1 reference

12 December 2020

Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons

1 reference

12 December 2020

Bim is a direct target of a neuronal E2F-dependent apoptotic pathway.

1 reference

12 December 2020

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

1 reference

12 December 2020

Genomic heterogeneity of DNA repair. Role in aging?

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12 December 2020

Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials

1 reference

12 December 2020

Phosphorylation of histone H3 is required for proper chromosome condensation and segregation

1 reference

12 December 2020

Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death.

1 reference

12 December 2020

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

12 December 2020

Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein

1 reference

12 December 2020

G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis

1 reference

12 December 2020

Constitutional aneuploidy in the normal human brain.

1 reference

12 December 2020

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

1 reference

12 December 2020

Marked improvement in adherence to traumatic brain injury guidelines in United States trauma centers

1 reference

12 December 2020

Changes in proliferating cell nuclear antigen, a protein involved in DNA repair, in vulnerable hippocampal neurons following global cerebral ischemia

1 reference

12 December 2020

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

1 reference

12 December 2020

Requirement for a functional Rb-1 gene in murine development

1 reference

12 December 2020

Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat

1 reference

12 December 2020

Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity

1 reference

12 December 2020

Thrombin in ischemic neuronal death

1 reference

12 December 2020

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

1 reference

12 December 2020

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis

1 reference

12 December 2020

Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment

1 reference

12 December 2020

Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.

1 reference

12 December 2020

DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3

1 reference

12 December 2020

Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia

1 reference

12 December 2020

The specificities of protein kinase inhibitors: an update

1 reference

12 December 2020

Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development

1 reference

12 December 2020

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

1 reference

12 December 2020

Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

1 reference

12 December 2020

Effects of an Rb mutation in the mouse

1 reference

12 December 2020

Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.

1 reference

12 December 2020

Mitotic signaling by beta-amyloid causes neuronal death

1 reference

12 December 2020

Acute inflammatory response in spinal cord following impact injury

1 reference

12 December 2020

Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models

1 reference

12 December 2020

The selectivity of protein kinase inhibitors: a further update

1 reference

12 December 2020

Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?

1 reference

12 December 2020

The origin recognition core complex regulates dendrite and spine development in postmitotic neurons

1 reference

12 December 2020

The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner

1 reference

12 December 2020

Astrocyte apoptosis: implications for neuroprotection

1 reference

12 December 2020

Neurite outgrowth inhibitors in gliotic tissue

1 reference

12 December 2020

Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine

1 reference

12 December 2020

Regulation of neuronal survival and death by E2F-dependent gene repression and derepression

1 reference

12 December 2020

Bax alpha perturbs T cell development and affects cell cycle entry of T cells

1 reference

12 December 2020

Evidence for stroke-induced neurogenesis in the human brain

1 reference

12 December 2020

Aneuploid neurons are functionally active and integrated into brain circuitry

1 reference

12 December 2020

Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis.

1 reference

12 December 2020

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

1 reference

12 December 2020

Incidence of traumatic brain injury in the United States, 2003.

1 reference

12 December 2020

Mechanisms of neural cell death: implications for development of neuroprotective treatment strategies

1 reference

12 December 2020

The role of the DNA damage response in neuronal development, organization and maintenance

1 reference

12 December 2020

10.1007/S12640-009-9050-0

Identifiers

DOI

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3 June 2018

1 reference

3 June 2018