(Q55118610)

21 June 2018

title

Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein. (English)

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21 June 2018

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5

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21 June 2018

Xiang-Peng Kong

6

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21 June 2018

author name string

Jessica E Chukwu

1

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21 June 2018

Jan T Pedersen

2

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21 June 2018

Lars Ø Pedersen

3

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21 June 2018

Christiane Volbracht

4

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21 June 2018

language of work or name

English

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publication date

18 April 2018

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21 June 2018

published in

Scientific Reports

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21 June 2018

volume

8

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21 June 2018

issue

1

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21 June 2018

page(s)

6209

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21 June 2018

Creative Commons Attribution 4.0 International

copyright license

start time

18 April 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/s41598-018-24276-4

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cites work

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Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

22 June 2018

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Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

22 June 2018

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Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

22 June 2018

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22 June 2018

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Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

1 reference

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22 June 2018

1 reference

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An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity

22 June 2018

1 reference

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22 June 2018

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22 June 2018

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Structural characterization of the core of the paired helical filament of Alzheimer disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Tau protein binds to microtubules through a flexible array of distributed weak sites

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Tau protein pathology in neurodegenerative diseases

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

Alzheimer's disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase-2B (calcineurin).

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5906480

ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

13 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-018-24276-4

inferred from DOI database lookup

7 January 2021

based on heuristic

A double-labeling immunohistochemical study of tau exon 10 in Alzheimer's disease, progressive supranuclear palsy and Pick's disease

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-018-24276-4

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41598-018-24276-4

1 reference

21 June 2018

Dimensions Publication ID

1103361101

0 references

Fatcat ID

release_sg3zqoracrdchhxxcj2kdpqble

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/sg3zqoracrdchhxxcj2kdpqble

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

5906480

1 reference

21 June 2018

PubMed publication ID

29670132

1 reference

21 June 2018