(Q55315206)

1 July 2018

title

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions. (English)

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1 July 2018

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4

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1 July 2018

Magnus Ingelman-Sundberg

series ordinal

3

object named as

Magnus Ingelman-Sundberg

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1 July 2018

1

Sabine U Vorrink

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1 July 2018

Yitian Zhou

2

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1 July 2018

publication date

1 June 2018

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1 July 2018

published in

Toxicological Sciences

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1 July 2018

volume

163

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1 July 2018

issue

2

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1 July 2018

page(s)

655-665

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1 July 2018

Creative Commons Attribution 4.0 International

copyright license

start time

24 March 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

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Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.

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Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

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3 July 2018

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3 July 2018

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3 July 2018

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3 July 2018

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3 July 2018

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Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.

3 July 2018

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Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds

3 July 2018

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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

3 July 2018

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3 July 2018

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Hepatotoxicity related to antirheumatic drugs

3 July 2018

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3 July 2018

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Clozapine-induced fatal fulminant hepatic failure: a case report

3 July 2018

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Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Emergency liver transplantation in amodiaquine-induced fulminant hepatitis

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Idiosyncratic drug hepatotoxicity

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Antimalarial Drug Toxicity

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Nefazodone (Serzone) withdrawn because of hepatotoxicity.

3 July 2018

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Timing of new black box warnings and withdrawals for prescription medications

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Concordance of the toxicity of pharmaceuticals in humans and in animals

3 July 2018

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Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration

3 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Diclofenac induced hepatitis. 3 cases with features of autoimmune chronic active hepatitis

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Clinical pharmacokinetics of tacrine.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Roles of mitogen-activated protein kinases in the regulation of CYP genes.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Drug-induced autoimmune hepatitis: clinical characteristics and prognosis.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Drugs associated with hepatotoxicity and their reporting frequency of liver adverse events in VigiBase: unified list based on international collaborative work.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Cellular imaging predictions of clinical drug-induced liver injury

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Results of European post-marketing surveillance of bosentan in pulmonary hypertension.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

FDA-approved drug labeling for the study of drug-induced liver injury

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5974779

Small intestinal sulphoxidation of Albendazole

30 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29590495

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparison of potentially hepatotoxic drugs among major US drug compendia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29590495

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/TOXSCI/KFY058

1 reference

1 July 2018

PMC publication ID

5974779

1 reference

1 July 2018

PubMed publication ID

29590495

1 reference

1 July 2018