(Q56338497)

5

object named as

Stephen P. Bottomley

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author name string

James A. Irving

1

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Lisa D. Cabrita

2

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Robert N. Pike

4

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James C. Whisstock

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

6

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language of work or name

1 reference

April 2003

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published in

Structure

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volume

11

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issue

4

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page(s)

387-397

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Ovalbumin and angiotensinogen lack serpin S-R conformational change

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Crystal structure of uncleaved ovalbumin at 1.95 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Intrinsic fluorescence changes and rapid kinetics of proteinase deformation during serpin inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Serpin-protease complexes are trapped as stable acyl-enzyme intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Structure of a serpin-protease complex shows inhibition by deformation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Heterogeneity in serpin-protease complexes as demonstrated by differences in the mechanism of complex breakdown

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Principles that govern the folding of protein chains

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The F-helix of serpins plays an essential, active role in the proteinase inhibition mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Structural basis of latency in plasminogen activator inhibitor-1

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Biological implications of a 3 A structure of dimeric antithrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The anticoagulant activation of antithrombin by heparin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

A 2.6 A structure of a serpin polymer and implications for conformational disease

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Cleaved antitrypsin polymers at atomic resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Plasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular forms

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Molecular and structural characterization of the heat-resistant thyroxine-binding globulin-Chicago

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Identification of positively charged residues contributing to the stability of plasminogen activator inhibitor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Formation and properties of C1-inhibitor polymers

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Serpins in prokaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Cultural, morphological, and physiological characteristics of Thermomonospora fusca (strain 190Th)

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Thermoanaerobacter tengcongensis sp. nov., a novel anaerobic, saccharolytic, thermophilic bacterium isolated from a hot spring in Tengcong, China

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Effects of mutations in the hinge region of serpins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Regulation of protein function by native metastability

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Alkaline serine proteinase from Thermomonospora fusca YX. Stability to heat and denaturants

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

How do thermophilic proteins deal with heat?

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Protein thermostability in extremophiles

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Elucidation of factors responsible for enhanced thermal stability of proteins: a structural genomics based study

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Factors enhancing protein thermostability

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Conformational Studies on Plasminogen Activator Inhibitor (PAI-1) in Active, Latent, Substrate, and Cleaved Forms

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Crystal structure of the apoptotic suppressor CrmA in its cleaved form

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Characterization and functional analysis of Serp3: a novel myxoma virus-encoded serpin involved in virulence.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Probing the equilibrium denaturation of the serpin alpha(1)-antitrypsin with single tryptophan mutants; evidence for structure in the urea unfolded state

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The effects of reactive centre loop length upon serpin polymerisation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The Z type variation of human alpha 1-antitrypsin causes a protein folding defect

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Three-state unfolding and self-association of maspin, a tumor-suppressing serpin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Probing the unfolding pathway of alpha1-antitrypsin.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Conformational change and intermediates in the unfolding of alpha 1-antichymotrypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Conformational disease

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Alpha1-antitrypsin deficiency--a model for conformational diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The finer things in X-ray diffraction data collection

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The Protein Data Bank

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

WHAT IF: a molecular modeling and drug design program

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Raster3D: photorealistic molecular graphics

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

The relation between the divergence of sequence and structure in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Protein structural alignments and functional genomics

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Determination and analysis of urea and guanidine hydrochloride denaturation curves

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

On the size of the active site in proteases. I. Papain

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Perturbation of a tertiary hydrogen bond in barstar by mutagenesis of the sole His residue to Gln leads to accumulation of at least one equilibrium folding intermediate.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021

Prevention of polymerization of M and Z alpha1-Antitrypsin (alpha1-AT) with trimethylamine N-oxide. Implications for the treatment of alpha1-at deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2803%2900057-1

7 January 2021