(Q57073168)

English

Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling

scientific article published on 01 January 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Parkinson's disease

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

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based on heuristic

inferred from title

parkinsonian syndrome

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based on heuristic

inferred from title

Andrii Domanskyi

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Rosanna Parlato

11

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Claus Rieker

1

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19 January 2020

David Engblom

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Grzegorz Kreiner

3

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Andreas Schober

5

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Stefanie Stotz

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Manuela Neumann

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Xuejun Yuan

8

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Ingrid Grummt

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Günther Schütz

10

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19 January 2020

language of work or name

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publication date

1 January 2011

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Europe PubMed Central

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19 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

31

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19 January 2020

2

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Europe PubMed Central

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19 January 2020

453-460

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6623444/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of translation initiation by FRAP/mTOR

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of HDM2 activity by the ribosomal protein L11

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of the TSC-mTOR pathway in human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular stress and nucleolar function

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radical medicine: treating ageing to cure disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TOR signaling in growth and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expanding insights of mitochondrial dysfunction in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics of Parkinson disease: paradigm shifts and future prospects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissecting p53-dependent apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival of DA neurons is independent of CREM upregulation in absence of CREB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multifunctional nucleolus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate receptors on dopamine neurons control the persistence of cocaine seeking.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial p53 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson's disease: from monogenic forms to genetic susceptibility factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generalized lacZ expression with the ROSA26 Cre reporter strain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21228155

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0590-10.2011

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21228155%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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