(Q34569422)

English

RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

Parkinson's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Cristina Malagelada

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

author name string

Elizabeth J Ryu

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

Subhas C Biswas

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

Lloyd A Greene

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

Vernice Jackson-Lewis

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

language of work or name

0 references

publication date

1 September 2006

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

26

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

39

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

9996-10005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

Discordant effects of rapamycin on proliferation and p70S6 kinase phosphorylation in normal and neoplastic rat chromaffin cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-2 mediates neuronal cell death induced by beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive loss of cardiac sympathetic innervation in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone-induced Gene 2 (dig2) Is a Novel Pro-survival Stress Gene Induced Rapidly by Diverse Apoptotic Signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson's disease: mechanisms and models

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Pathways of Neurodegeneration in Parkinson's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of toxicity in rotenone models of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initiation of neuronal damage by complex I deficiency and oxidative stress in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of oxygen-induced retinopathy in RTP801-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of gene expression changes in a cellular model of Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TOR signaling: an odyssey from cellular stress to the cell growth machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfate through CCAA/enhancer binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheb binds and regulates the mTOR kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mTOR and cell growth in response to energy stress by REDD1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TOR signaling in growth and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A clinicopathologic study of 100 cases of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autonomic dysfunction in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medical treatment of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17005863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3292-06.2006

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674487&resulttype=core&format=json

11 May 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34569422&oldid=1598858498"