(Q58090204)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

title

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

Heat shock protein 90 alpha family class B member 1

1 May 2020

main subject

1 reference

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Javier Oroz

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Bliss J Chang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Angel Pérez-Lara

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Laura J. Blair

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Chad A Dickey

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Markus Zweckstetter

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

11

Henning Urlaub

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

author name string

Piotr Wysoczanski

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Chung-Tien Lee

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Pijush Chakraborty

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Romina V Hofele

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Jeremy D Baker

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Jacek Biernat

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Eckhard Mandelkow

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

language of work or name

English

0 references

publication date

31 October 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

issue

1

1 reference

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1 May 2020

page(s)

4532

1 reference

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https://scigraph.springernature.com/pub.10.1038/s41467-018-06880-0

1 May 2020

exact match

0 references

cites work

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Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

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Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

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7 January 2021

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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

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7 January 2021

The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

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7 January 2021

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

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7 January 2021

Structural basis for the antifolding activity of a molecular chaperone

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7 January 2021

A molecular mechanism of chaperone-client recognition.

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7 January 2021

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

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7 January 2021

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

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7 January 2021

Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors

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7 January 2021

Hsp90: breaking the symmetry.

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7 January 2021

Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle

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7 January 2021

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

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7 January 2021

Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40

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7 January 2021

Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.

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7 January 2021

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

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7 January 2021

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7 January 2021

Structural Basis for Signal-Sequence Recognition by the Translocase Motor SecA as Determined by NMR

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7 January 2021

The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain

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7 January 2021

High-resolution four-dimensional 1H-13C NOE spectroscopy using methyl-TROSY, sparse data acquisition, and multidimensional decomposition

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7 January 2021

Large Rotation of the N-terminal Domain of Hsp90 Is Important for Interaction with Some but Not All Client Proteins.

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7 January 2021

Isolation of Hsp90 mutants by screening for decreased steroid receptor function

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7 January 2021

The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function

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7 January 2021

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

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7 January 2021

Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data

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7 January 2021

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.

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7 January 2021

Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.

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7 January 2021

Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.

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7 January 2021

Akt and CHIP coregulate tau degradation through coordinated interactions

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7 January 2021

Classification of intrinsically disordered regions and proteins

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7 January 2021

Binding Mechanisms of Intrinsically Disordered Proteins: Theory, Simulation, and Experiment

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7 January 2021

Fuzzy complexes: Specific binding without complete folding

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7 January 2021

Conformational dynamics of the molecular chaperone Hsp90

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7 January 2021

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

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7 January 2021

Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex

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7 January 2021

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle

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7 January 2021

Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy

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7 January 2021

Phosphorylation pattern of tau associated with distinct changes of the growth cone cytoskeleton.

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7 January 2021

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7 January 2021

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

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7 January 2021

Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease

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7 January 2021

Isotope labeling strategies for the study of high-molecular-weight proteins by solution NMR spectroscopy.

1 reference

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7 January 2021

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions

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7 January 2021

Structural polymorphism of 441-residue tau at single residue resolution

1 reference

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7 January 2021

Protein NMR using paramagnetic ions

1 reference

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7 January 2021

A pH-sensitive, colorful, lanthanide-chelating paramagnetic NMR probe

1 reference

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7 January 2021

Design, synthesis, and evaluation of a lanthanide chelating protein probe: CLaNP-5 yields predictable paramagnetic effects independent of environment.

1 reference

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7 January 2021

Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes.

1 reference

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7 January 2021

Sparse multidimensional iterative lineshape-enhanced (SMILE) reconstruction of both non-uniformly sampled and conventional NMR data

1 reference

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7 January 2021

Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes

1 reference

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7 January 2021

Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.

1 reference

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7 January 2021

Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90.

1 reference

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7 January 2021

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

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7 January 2021

Expanding the chemical cross-linking toolbox by the use of multiple proteases and enrichment by size exclusion chromatography

1 reference

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7 January 2021

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

1 reference

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7 January 2021

Insights into the activation of the helicase Prp43 by biochemical studies and structural mass spectrometry

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-06880-0

7 January 2021

Identification of cross-linked peptides from complex samples.

1 reference

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7 January 2021

The HADDOCK web server for data-driven biomolecular docking

1 reference

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7 January 2021

Scrambling free combinatorial labeling of alanine-β, isoleucine-δ1, leucine-proS and valine-proS methyl groups for the detection of long range NOEs

1 reference

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7 January 2021

Distance restraints from crosslinking mass spectrometry: mining a molecular dynamics simulation database to evaluate lysine-lysine distances

1 reference

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7 January 2021

Elucidating the mechanism of substrate recognition by the bacterial Hsp90 molecular chaperone

1 reference

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7 January 2021

Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements

1 reference

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7 January 2021

Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast.

1 reference

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7 January 2021

Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering

1 reference

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7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30382094

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41467-018-06880-0

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 May 2020

ADS bibcode

2018NatCo...9.4532O

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30382094%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PubMed publication ID

30382094

1 reference