(Q64056540)

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26 April 2020

2 references

8 February 2021

29 April 2021

Potential Applications of NRF2 Inhibitors in Cancer Therapy (English)

1 reference

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26 April 2020

1 reference

8 February 2021

nuclear factor erythroid 2-related factor 2

1 reference

29 April 2021

1

1 reference

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26 April 2020

Luciano Saso

series ordinal

2

1 reference

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26 April 2020

author name string

Emiliano Panieri

series ordinal

1

0 references

Luciano Saso

series ordinal

2

0 references

language of work or name

English

0 references

publication date

11 April 2019

3 references

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26 April 2020

8 February 2021

29 April 2021

Oxidative medicine and cellular longevity

3 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31097977%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

8 February 2021

29 April 2021

2019

1 reference

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26 April 2020

page(s)

8592348

1 reference

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Creative Commons Attribution 4.0 International

26 April 2020

copyright license

2 references

8 February 2021

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element

29 April 2021

cites work

1 reference

12 December 2020

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.

1 reference

12 December 2020

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

1 reference

12 December 2020

Antioxidant-inducible genes

1 reference

12 December 2020

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

12 December 2020

Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis

1 reference

12 December 2020

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

12 December 2020

Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

1 reference

12 December 2020

Targets of oncogenes and tumor suppressors: key for understanding basic mechanisms of carcinogenesis.

1 reference

12 December 2020

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

12 December 2020

Functional characterization of transcription regulators that interact with the electrophile response element

1 reference

12 December 2020

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

1 reference

12 December 2020

Rules for making human tumor cells

1 reference

12 December 2020

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

1 reference

12 December 2020

Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

1 reference

12 December 2020

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

1 reference

12 December 2020

Akt stimulates aerobic glycolysis in cancer cells

1 reference

12 December 2020

Cancer genes and the pathways they control

1 reference

12 December 2020

Redox activation of p21Cip1/WAF1/Sdi1: a multifunctional regulator of cell survival and death

1 reference

12 December 2020

Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin

1 reference

12 December 2020

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

1 reference

12 December 2020

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

1 reference

12 December 2020

Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells.

1 reference

12 December 2020

The consensus coding sequences of human breast and colorectal cancers

1 reference

12 December 2020

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

1 reference

12 December 2020

Mechanisms of cell death in oxidative stress

1 reference

12 December 2020

The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease

1 reference

12 December 2020

Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells

1 reference

12 December 2020

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

1 reference

12 December 2020

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

1 reference

12 December 2020

Protein damage by reactive electrophiles: targets and consequences

1 reference

12 December 2020

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

1 reference

12 December 2020

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

1 reference

12 December 2020

Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines

1 reference

12 December 2020

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

1 reference

12 December 2020

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

1 reference

12 December 2020

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

1 reference

12 December 2020

Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer

1 reference

12 December 2020

The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease

1 reference

12 December 2020

Prospective type 1 and type 2 disulfides of Keap1 protein.

1 reference

12 December 2020

1 reference

12 December 2020

Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes

1 reference

12 December 2020

In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica.

1 reference

12 December 2020

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

1 reference

12 December 2020

Bruceine D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase.

1 reference

12 December 2020

Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer

1 reference

12 December 2020

A new triterpenoid from Brucea javanica.

1 reference

12 December 2020

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

1 reference

12 December 2020

Cysteine-based regulation of the CUL3 adaptor protein Keap1

1 reference

12 December 2020

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

1 reference

12 December 2020

Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations

1 reference

12 December 2020

Targeting NRF2 signaling for cancer chemoprevention

1 reference

12 December 2020

NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation

1 reference

12 December 2020

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model

1 reference

12 December 2020

Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2

1 reference

12 December 2020

Silencing MRP4 by small interfering RNA reverses acquired DDP resistance of gastric cancer cell

1 reference

12 December 2020

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

1 reference

12 December 2020

Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice

1 reference

12 December 2020

Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.

1 reference

12 December 2020

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

1 reference

12 December 2020

Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer

1 reference

12 December 2020

A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells

1 reference

12 December 2020

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway

1 reference

12 December 2020

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

1 reference

12 December 2020

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

1 reference

12 December 2020

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

1 reference

12 December 2020

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.

1 reference

12 December 2020

High levels of Nrf2 determine chemoresistance in type II endometrial cancer

1 reference

12 December 2020

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

1 reference

12 December 2020

Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

1 reference

12 December 2020

Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome

1 reference

12 December 2020

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

1 reference

12 December 2020

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

1 reference

12 December 2020

KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma

1 reference

12 December 2020

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

1 reference

12 December 2020

Hallmarks of Cancer: The Next Generation

1 reference

12 December 2020

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs.

1 reference

12 December 2020

NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease.

1 reference

12 December 2020

Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines

1 reference

12 December 2020

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

1 reference

12 December 2020

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

1 reference

12 December 2020

miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells

1 reference

12 December 2020

Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities.

1 reference

12 December 2020

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer

1 reference

12 December 2020

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

1 reference

12 December 2020

Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer

1 reference

12 December 2020

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

1 reference

12 December 2020

Beneficial role of Nrf2 in regulating NADPH generation and consumption

1 reference

12 December 2020

The heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signal

1 reference

12 December 2020

Association of keap1 and nrf2 genetic mutations and polymorphisms with endometrioid endometrial adenocarcinoma survival

1 reference

12 December 2020

Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract

1 reference

12 December 2020

miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells

1 reference

12 December 2020

NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer

1 reference

12 December 2020

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma

1 reference

12 December 2020

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

1 reference

12 December 2020

Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein

1 reference

12 December 2020

Astroglial pentose phosphate pathway rates in response to high-glucose environments.

1 reference

12 December 2020

Methylation of the KEAP1 gene promoter region in human colorectal cancer

1 reference

12 December 2020

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

1 reference

12 December 2020

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

1 reference

12 December 2020

Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-α in breast cancer cells

1 reference

12 December 2020

NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity

1 reference

12 December 2020

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

1 reference

12 December 2020

Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response

1 reference

12 December 2020

1 reference

12 December 2020

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis

1 reference

12 December 2020

MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas

1 reference

12 December 2020

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

1 reference

12 December 2020

NRF2 and cancer: the good, the bad and the importance of context.

1 reference

12 December 2020

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

1 reference

12 December 2020

Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks

1 reference

12 December 2020

A possible gene silencing mechanism: hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells

1 reference

12 December 2020

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

1 reference

12 December 2020

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

1 reference

12 December 2020

Synergistic inhibition of mesothelioma cell growth by the combination of clofarabine and resveratrol involves Nrf2 downregulation

1 reference

12 December 2020

Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells

1 reference

12 December 2020

Aberrant Keap1 methylation in breast cancer and association with clinicopathological features

1 reference

12 December 2020

The noncytotoxic dose of sorafenib sensitizes Bel-7402/5-FU cells to 5-FU by down-regulating 5-FU-induced Nrf2 expression

1 reference

12 December 2020

Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells.

1 reference

12 December 2020

CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma

1 reference

12 December 2020

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination

1 reference

12 December 2020

Regulation of Nrf2-an update

1 reference

12 December 2020

MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis

1 reference

12 December 2020

Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway

1 reference

12 December 2020

Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner

1 reference

12 December 2020

Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis

1 reference

12 December 2020

Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer

1 reference

12 December 2020

KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells

1 reference

12 December 2020

Parthenolide: from plant shoots to cancer roots

1 reference

12 December 2020

Feedback loop between p66(Shc) and Nrf2 promotes lung cancer progression

1 reference

12 December 2020

Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways

1 reference

12 December 2020

ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells

1 reference

12 December 2020

Identification of driver genes in hepatocellular carcinoma by exome sequencing

1 reference

12 December 2020

Involvement of Nrf2-mediated upregulation of heme oxygenase-1 in mollugin-induced growth inhibition and apoptosis in human oral cancer cells

1 reference

12 December 2020

Novel hematopoietic target genes in the NRF2-mediated transcriptional pathway

1 reference

12 December 2020

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

1 reference

12 December 2020

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis.

1 reference

12 December 2020

A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance

1 reference

12 December 2020

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

1 reference

12 December 2020

Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway

1 reference

12 December 2020

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy

1 reference

12 December 2020

Understanding the role of NRF2-regulated miRNAs in human malignancies.

1 reference

12 December 2020

Keap1 mutations in lung cancer patients

1 reference

12 December 2020

Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer

1 reference

12 December 2020

DNA damage and oxidative stress in human disease

1 reference

12 December 2020

Nrf2 overexpression predicts prognosis and 5-FU resistance in gastric cancer

1 reference

12 December 2020

Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer

1 reference

12 December 2020

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.

1 reference

12 December 2020

Retinoids and their biological effects against cancer

1 reference

12 December 2020

The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors

1 reference

12 December 2020

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination

1 reference

12 December 2020

Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine

1 reference

12 December 2020

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

1 reference

12 December 2020

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

1 reference

12 December 2020

Convallatoxin, a dual inducer of autophagy and apoptosis, inhibits angiogenesis in vitro and in vivo

1 reference

12 December 2020

Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells

1 reference

12 December 2020

Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress

1 reference

12 December 2020

Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation

1 reference

12 December 2020

Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo.

1 reference

12 December 2020

The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.

1 reference

12 December 2020

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy

1 reference

12 December 2020

Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma

1 reference

12 December 2020

The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer.

1 reference

12 December 2020

Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis.

1 reference

12 December 2020

The PTEN/NRF2 axis promotes human carcinogenesis

1 reference

12 December 2020

The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2.

1 reference

12 December 2020

Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents.

1 reference

12 December 2020

Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells

1 reference

12 December 2020

Knockdown of nuclear factor erythroid 2-related factor 2 by lentivirus induces differentiation of glioma stem-like cells.

1 reference

12 December 2020

Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP501 in vitro

1 reference

12 December 2020

AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells

1 reference

12 December 2020

Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways

1 reference

12 December 2020

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes

1 reference

12 December 2020

Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer

1 reference

12 December 2020

Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?

1 reference

12 December 2020

RETRACTED: Nrf2/p62 signaling in apoptosis resistance and its role in cadmium-induced carcinogenesis

1 reference

12 December 2020

Estrogen increases Nrf2 activity through activation of the PI3K pathway in MCF-7 breast cancer cells

1 reference

12 December 2020

Cytoprotection "gone astray": Nrf2 and its role in cancer

1 reference

12 December 2020

The sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencing

1 reference

12 December 2020

MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis

1 reference

12 December 2020

Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway.

1 reference

12 December 2020

Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer

1 reference

12 December 2020

p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system.

1 reference

12 December 2020

SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation

1 reference

12 December 2020

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

1 reference

12 December 2020

Oncogenic KRAS confers chemoresistance by upregulating NRF2.

1 reference

12 December 2020

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.

1 reference

12 December 2020

The single N-glycan deletion mutant of soluble ErbB3 protein attenuates heregulin β1-induced tumor progression by blocking of the HIF-1 and Nrf2 pathway.

1 reference

12 December 2020

Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer

1 reference

12 December 2020

miR-340 reverses cisplatin resistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway

1 reference

12 December 2020

Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells

1 reference

12 December 2020

Impact of nuclear factor erythroid-derived 2-like 2 and p62/sequestosome expression on prognosis of patients with gliomas.

1 reference

12 December 2020

MiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil

1 reference

12 December 2020

The emerging role of Nrf2 in mitochondrial function

1 reference

12 December 2020

Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation

1 reference

12 December 2020

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

1 reference

12 December 2020

A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer

1 reference

12 December 2020

Aberrantly elevated redox sensing factor Nrf2 promotes cancer stem cell survival via enhanced transcriptional regulation of ABCG2 and Bcl-2/Bmi-1 genes.

1 reference

12 December 2020

Methylseleninic acid activates Keap1/Nrf2 pathway via up-regulating miR-200a in human oesophageal squamous cell carcinoma cells

1 reference

12 December 2020

miRNA Influences in NRF2 Pathway Interactions within Cancer Models

1 reference

12 December 2020

Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract

1 reference

12 December 2020

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

1 reference

12 December 2020

Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway

1 reference

12 December 2020

Reactive oxygen species mediate oridonin-induced apoptosis through DNA damage response and activation of JNK pathway in diffuse large B cell lymphoma

1 reference

12 December 2020

The complexity of the Nrf2 pathway: beyond the antioxidant response

1 reference

12 December 2020

MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression

1 reference

12 December 2020

UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis

1 reference

12 December 2020

Monitoring the Antioxidant Mediated Chemosensitization and ARE-Signaling in Triple Negative Breast Cancer Therapy

1 reference

12 December 2020

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic.

1 reference

12 December 2020

Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells

1 reference

12 December 2020

Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.

1 reference

12 December 2020

Downregulation of Nrf2 by the combination of TRAIL and Valproic acid induces apoptotic cell death of TRAIL-resistant papillary thyroid cancer cells via suppression of Bcl-xL.

1 reference

12 December 2020

Dehydroepiandrosterone triggers autophagic cell death in human hepatoma cell line HepG2 via JNK-mediated p62/SQSTM1 expression.

1 reference

12 December 2020

Inhibition of heme oxygenase-1 enhances the chemosensitivity of laryngeal squamous cell cancer Hep-2 cells to cisplatin

1 reference

12 December 2020

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway

1 reference

12 December 2020

NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming.

1 reference

12 December 2020

Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.

1 reference

12 December 2020

MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer

1 reference

12 December 2020

Oridonin inhibits the proliferation of human colon cancer cells by upregulating BMP7 to activate p38 MAPK.

1 reference

12 December 2020

Oxidative stress and lipotoxicity

1 reference

12 December 2020

MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis.

1 reference

12 December 2020

Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib

1 reference

12 December 2020

NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG

1 reference

12 December 2020

Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis

1 reference

12 December 2020

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

1 reference

12 December 2020

Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma

1 reference

12 December 2020

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

1 reference

12 December 2020

PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species

1 reference

12 December 2020

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

1 reference

12 December 2020

Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation.

1 reference

12 December 2020

Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma

1 reference

12 December 2020

The Dual Roles of NRF2 in Cancer.

1 reference

12 December 2020

Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters.

1 reference

12 December 2020

NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells

1 reference

12 December 2020

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

1 reference

12 December 2020

Brusatol Enhances the Radiosensitivity of A549 Cells by Promoting ROS Production and Enhancing DNA Damage

1 reference

12 December 2020

Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS.

1 reference

12 December 2020

Regulation and function of AMPK in physiology and diseases

1 reference

12 December 2020

miR-144 reverses chemoresistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway

1 reference

12 December 2020

Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer

1 reference

12 December 2020

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

1 reference

12 December 2020

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

1 reference

12 December 2020

Anticancer activity of Honokiol against lymphoid malignant cells via activation of ROS-JNK and attenuation of Nrf2 and NF-κB.

1 reference

12 December 2020

Involvement of NRF2 Signaling in Doxorubicin Resistance of Cancer Stem Cell-Enriched Colonospheres

1 reference

12 December 2020

Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression

1 reference

12 December 2020

Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer

1 reference

12 December 2020

Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming

1 reference

12 December 2020

Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells.

1 reference

12 December 2020

Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance.

1 reference

12 December 2020

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

1 reference

12 December 2020

Targeting of the Glutathione, Thioredoxin, and Nrf2 Antioxidant Systems in Head and Neck Cancer

1 reference

12 December 2020

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.

1 reference

12 December 2020

TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin

1 reference

12 December 2020

Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells

1 reference

12 December 2020

Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells.

1 reference

12 December 2020

Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment

1 reference

12 December 2020

Brusatol overcomes chemoresistance through inhibition of protein translation.

1 reference

12 December 2020

Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.

1 reference

12 December 2020

NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway

1 reference

12 December 2020

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma.

1 reference

12 December 2020

Elevated expression of Nrf2 mediates multidrug resistance in CD133(+) head and neck squamous cell carcinoma stem cells

1 reference

12 December 2020

ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells

1 reference

12 December 2020

Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia.

1 reference

12 December 2020

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

1 reference

12 December 2020

RETRACTED ARTICLE: Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation

1 reference

12 December 2020

Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.

1 reference

12 December 2020

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.

1 reference

12 December 2020

The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment.

1 reference

12 December 2020

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.

1 reference

12 December 2020

Diosmetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury through Activating the Nrf2 Pathway and Inhibiting the NLRP3 Inflammasome

1 reference

12 December 2020

Role of Nrf2 signaling pathway in the radiation tolerance of patients with head and neck squamous cell carcinoma: an in vivo and in vitro study

1 reference

12 December 2020

Enforced miR-144-3p Expression as a Non-Invasive Biomarker for the Acute Myeloid Leukemia Patients Mainly by Targeting NRF2.

1 reference

12 December 2020

Nrf2 promotes progression of non-small cell lung cancer through activating autophagy.

1 reference

12 December 2020

NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.

1 reference

12 December 2020

Brusatol inhibits growth and induces apoptosis in pancreatic cancer cells via JNK/p38 MAPK/NF-κb/Stat3/Bcl-2 signaling pathway.

1 reference

12 December 2020

Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans.

1 reference

12 December 2020

Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling

1 reference

12 December 2020

PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy.

1 reference

12 December 2020

A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer

1 reference

12 December 2020

Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2

1 reference

12 December 2020

Synergistic anti-tumor activity of Nimotuzumab in combination with Trastuzumab in HER2-positive breast cancer

1 reference

12 December 2020

RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

1 reference

12 December 2020

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.

1 reference

12 December 2020

Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop

1 reference

12 December 2020

The Wnt inhibitor LGK-974 enhances radiosensitivity of HepG2 cells by modulating Nrf2 signaling

1 reference

12 December 2020

MicroRNA-144 modulates oxidative stress tolerance in SH-SY5Y cells by regulating nuclear factor erythroid 2-related factor 2-glutathione axis

1 reference

12 December 2020

MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells.

1 reference

12 December 2020

The see-saw of Keap1-Nrf2 pathway in cancer

1 reference

12 December 2020

NRF2 overexpression in mesenchymal stem cells induces stem-cell marker expression and enhances osteoblastic differentiation

1 reference

12 December 2020

miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1.

1 reference

12 December 2020

The roles of NRF2 in modulating cellular iron homeostasis.

1 reference

12 December 2020

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

1 reference

12 December 2020

Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.

1 reference

12 December 2020

Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas.

1 reference

12 December 2020

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

1 reference

12 December 2020

Camptothecin suppresses NRF2-ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs

1 reference

12 December 2020

Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells

1 reference

12 December 2020

FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4-GSK3β-Nrf2 Signaling.

1 reference

12 December 2020

Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy

1 reference

12 December 2020

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

1 reference

12 December 2020

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.

1 reference

12 December 2020

ROS-independent Nrf2 activation in prostate cancer

1 reference

12 December 2020

Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells

1 reference

12 December 2020

High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

1 reference

12 December 2020

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action.

1 reference

12 December 2020

Procyanidins from Cinnamomi Cortex promote proteasome-independent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells

1 reference

12 December 2020

Regulation of Keap1-Nrf2 signaling: The role of epigenetics

1 reference

12 December 2020

Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells

1 reference

12 December 2020

Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance

1 reference

12 December 2020

Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics.

1 reference

12 December 2020

Nrf2 induces cisplatin resistance via suppressing the iron export related gene SLC40A1 in ovarian cancer cells

1 reference

12 December 2020

Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities.

1 reference

12 December 2020

Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway

1 reference

12 December 2020

Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis

1 reference

12 December 2020

Nrf2 promotes oesophageal cancer cell proliferation via metabolic reprogramming and detoxification of reactive oxygen species.

1 reference

12 December 2020

CDCA4, a downstream gene of the Nrf2 signaling pathway, regulates cell proliferation and apoptosis in the MCF‑7/ADM human breast cancer cell line

1 reference

12 December 2020

NRF2 facilitates breast cancer cell growth via HIF1ɑ-mediated metabolic reprogramming

1 reference

12 December 2020

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.

1 reference

12 December 2020

NFE2L2/NRF2 silencing-inducible miR-206 targets c-MET/EGFR and suppresses BCRP/ABCG2 in cancer cells

1 reference

12 December 2020

Repurposing of the CDK inhibitor PHA-767491 as a NRF2 inhibitor drug candidate for cancer therapy via redox modulation.

1 reference

12 December 2020

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway

1 reference

12 December 2020

Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin.

1 reference

12 December 2020

NRF2 Regulates HER1 Signaling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to Lapatinib and Erlotinib.

1 reference

12 December 2020

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells.

1 reference

12 December 2020

The Crosstalk between Nrf2 and Inflammasomes.

1 reference

12 December 2020

Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway.

1 reference

12 December 2020

Oncogenic mutations in KEAP1 disturbing inhibitory Nrf2-Keap1 interaction: Activation of antioxidative pathway in papillary thyroid carcinoma.

1 reference

12 December 2020

Sulforaphane Attenuated the Pro-Inflammatory State Induced by Hydrogen Peroxide in SH-SY5Y Cells Through the Nrf2/HO-1 Signaling Pathway

1 reference

12 December 2020

Nrf-2 transcriptionally activates P21Cip/WAF1 and promotes A549 cell survival against oxidative stress induced by H2O2.

1 reference

12 December 2020

Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).

1 reference

12 December 2020

Suppression of Nrf2 confers chemosensitizing effect through enhanced oxidant-mediated mitochondrial dysfunction

1 reference

12 December 2020

miR-148b Functions as a Tumor Suppressor by Targeting Endoplasmic Reticulum Metallo Protease 1 in Human Endometrial Cancer Cells

1 reference

12 December 2020

Redox-Sensitive Transcription Factor NRF2 Enhances Trophoblast Differentiation via Induction of miR-1246 and Aromatase.

1 reference

12 December 2020

A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance.

1 reference

12 December 2020

Clinical and pathological characteristics of KEAP1- and NFE2L2- mutated non-small cell lung carcinoma (NSCLC).

1 reference

12 December 2020

Impact of Nrf2 on tumor growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo.

1 reference

12 December 2020

2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells.

1 reference

12 December 2020

Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs.

1 reference

12 December 2020

Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation

1 reference

12 December 2020

Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway.

1 reference

12 December 2020

UVA Irradiation Enhances Brusatol-Mediated Inhibition of Melanoma Growth by Downregulation of the Nrf2-Mediated Antioxidant Response.

1 reference

12 December 2020

Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling

1 reference

12 December 2020

High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance.

1 reference

12 December 2020

NRF2 and the Hallmarks of Cancer

1 reference

12 December 2020

GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells.

1 reference

12 December 2020

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation

1 reference

12 December 2020

Sulfiredoxin-1 enhances cardiac progenitor cell survival against oxidative stress via the upregulation of the ERK/NRF2 signal pathway

1 reference

12 December 2020

Metformin Induces Apoptosis and Alters Cellular Responses to Oxidative Stress in Ht29 Colon Cancer Cells: Preliminary Findings.

1 reference

12 December 2020

Small-Molecule Screening for Genetic Diseases.

1 reference

12 December 2020

Resistance to gefitinib and cross-resistance to irreversible EGFR-TKIs mediated by disruption of the Keap1-Nrf2 pathway in human lung cancer cells.

1 reference

12 December 2020

Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway.

1 reference

12 December 2020

Inhibition of PDGFR by CP-673451 induces apoptosis and increases cisplatin cytotoxicity in NSCLC cells via inhibiting the Nrf2-mediated defense mechanism

1 reference

12 December 2020

Suppression of NRF2/ARE by convallatoxin sensitises A549 cells to 5-FU-mediated apoptosis

1 reference

12 December 2020

Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism

1 reference

12 December 2020

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

1 reference

12 December 2020

Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.

1 reference

12 December 2020

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells.

1 reference

12 December 2020

Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells.

1 reference

12 December 2020

Activation of the KEAP1‑NRF2‑ARE signaling pathway reduces oxidative stress in Hep2 cells.

1 reference

12 December 2020

KEAP1/NRF2 signaling pathway mutations in cervical cancer

1 reference

12 December 2020

Novel Neohesperidin Dihydrochalcone Analogue Inhibits Adipogenic Differentiation of Human Adipose-Derived Stem Cells through the Nrf2 Pathway

1 reference

12 December 2020

Nrf2 activation attenuates the early suppression of mitochondrial respiration due to the α-synuclein overexpression

1 reference

12 December 2020

A catalogue of somatic NRF2 gain-of-function mutations in cancer

1 reference

12 December 2020

High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling.

1 reference

12 December 2020

Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages

1 reference

12 December 2020

Identifiers

DOI

10.1155/2019/8592348

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31097977%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31097977%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

1 reference