(Q74355214)

English

RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome

scientific article published on 01 May 2002

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Europe PubMed Central

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10 November 2019

RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome (English)

1 reference

Europe PubMed Central

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10 November 2019

Li-Fraumeni syndrome

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10 November 2019

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Diane Crighton

2

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10 November 2019

John M Boyle

3

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10 November 2019

Jennifer M Varley

4

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10 November 2019

Robert J White

5

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10 November 2019

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1 May 2002

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10 November 2019

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10 November 2019

21

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10 November 2019

2961-2970

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10 November 2019

19

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10 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205372

0 references

Suppression of human colorectal carcinoma cell growth by wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

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Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

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Cyclin D1 as a cellular proto-oncogene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

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Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 is a general repressor of RNA polymerase III transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of neural BC200 RNA in human tumours.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of neural BC1 RNA: Induction in murine tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Gain of function mutations in p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

The p53-deficient mouse: a model for basic and applied cancer studies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for TAF3B2 in the repression of human RNA polymerase III transcription in nonproliferating cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Overproduction of p53 antigen makes established cells highly tumorigenic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild-type p53 activates transcription in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

The p53 proto-oncogene can act as a suppressor of transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild-type p53 can down-modulate the activity of various promoters

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemical properties and biological effects of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 mutations in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

S. cerevisiae TFIIIB is the transcription initiation factor proper of RNA polymerase III, while TFIIIA and TFIIIC are assembly factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of p53 as a sequence-specific DNA-binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Repression of the basal c-fos promoter by wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of RNA polymerase III transcription in cells transformed by simian virus 40

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

High metastatic potential in mice inheriting a targeted p53 missense mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptotic and growth-promoting activity of E2F modulated by MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 sends nucleotides to repair DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

The MDM2 gene amplification database

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Connections between growth and the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Survey and summary: transcription by RNA polymerases I and III.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of RNA polymerase III transcription during cell cycle entry

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild-type p53 binds to the TATA-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

The cellular response to p53: the decision between life and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of the in vitro transforming activities of human papillomavirus types.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of germline TP53 splicing mutations and their genetic and functional analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Li-Fraumeni syndrome--a molecular and clinical review

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of the cell cycle by viral oncoproteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

p53: death star

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitotic regulation of a TATA-binding-protein-containing complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of RNA polymerase III transcription in response to F9 embryonal carcinoma stem cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Repression of RNA polymerase III transcription by the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of tumor suppressors on cell cycle-regulatory genes: RB suppresses p34cdc2 expression and normal p53 suppresses cyclin A expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and classification of p53-regulated genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205372

7 January 2021

based on heuristic

inferred from DOI database lookup

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