(Q80768190)

English

Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition

scientific article published on 01 August 2007

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

author name string

Kun Zou

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Haruyasu Yamaguchi

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Hiroyasu Akatsu

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Takaaki Sakamoto

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Mihee Ko

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Kazushige Mizoguchi

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Jian-Sheng Gong

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Wenxin Yu

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Takayuki Yamamoto

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Kenji Kosaka

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Katsuhiko Yanagisawa

11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Makoto Michikawa

12

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

publication date

1 August 2007

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

27

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

8628-8635

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

32

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The production of amyloid beta peptide is a critical requirement for the viability of central neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic-controlled hydrolysis of Leu-Val-Val-hemorphin-7 catalyzed by angiotensin-converting enzyme from rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer disease risk and genetic variation in ACE: a meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dementia and antihypertensive treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PEN-2 enhances gamma-cleavage after presenilin heterodimer formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin and Alzheimer's disease: therapeutic prospects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antihypertensive medication use and incident Alzheimer disease: the Cache County Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptidyl dipeptidase A: angiotensin I-converting enzyme.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression and tissue localization of the two isoforms of angiotensin I converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble multimeric Alzheimer beta(1-40) pre-amyloid complexes in dilute solution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17687040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1549-07.2007

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17687040%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q80768190&oldid=1399514592"