(Q83230171)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31294695%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

title

The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells (English)

1 reference

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24 April 2020

0 references

1

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24 April 2020

Courtney L Andersen

3

1 reference

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24 April 2020

Jacob E Corn

11

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24 April 2020

author name string

Justin Cidado

2

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24 April 2020

Cortni Dick

4

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24 April 2020

Pei-Chun Lin

5

1 reference

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24 April 2020

Therese Mitros

6

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24 April 2020

Hong Ma

7

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24 April 2020

Seung Hyun Baik

8

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24 April 2020

Matthew A Belmonte

9

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24 April 2020

Lisa Drew

10

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24 April 2020

language of work or name

English

0 references

publication date

11 July 2019

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24 April 2020

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24 April 2020

volume

8

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describes a project that uses

24 April 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6701926/fullTextXML

inferred from PubMed Central ID database lookup

cites work

In vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins

1 reference

12 December 2020

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

1 reference

12 December 2020

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

12 December 2020

VDAC2 inhibits BAK activation and mitochondrial apoptosis

1 reference

12 December 2020

Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissues

1 reference

12 December 2020

T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 gene

1 reference

12 December 2020

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

1 reference

12 December 2020

Function and regulation of cullin-RING ubiquitin ligases

1 reference

12 December 2020

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

1 reference

12 December 2020

EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors

1 reference

12 December 2020

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

1 reference

12 December 2020

Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases

1 reference

12 December 2020

DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis

1 reference

12 December 2020

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification

1 reference

12 December 2020

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

1 reference

12 December 2020

Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex

1 reference

12 December 2020

Resveratrol enhances anti-proliferative effect of VACM-1/cul5 in T47D cancer cells

1 reference

12 December 2020

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines

1 reference

12 December 2020

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

1 reference

12 December 2020

The essential role of evasion from cell death in cancer

1 reference

12 December 2020

MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5.

1 reference

12 December 2020

The Role of Elongin BC-Containing Ubiquitin Ligases

1 reference

12 December 2020

Structure-guided design of a selective BCL-X(L) inhibitor

1 reference

12 December 2020

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia

1 reference

12 December 2020

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

1 reference

12 December 2020

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin

1 reference

12 December 2020

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

1 reference

12 December 2020

Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1.

1 reference

12 December 2020

Efficacy of cyclin-dependent-kinase 9 inhibitors in a murine model of mixed-lineage leukemia

1 reference

12 December 2020

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

1 reference

12 December 2020

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

1 reference

12 December 2020

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

1 reference

12 December 2020

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

1 reference

12 December 2020

CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo.

1 reference

12 December 2020

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

1 reference

12 December 2020

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

1 reference

12 December 2020

Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design

1 reference

12 December 2020

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression

1 reference

12 December 2020

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor

1 reference

12 December 2020

Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer

1 reference

12 December 2020

Cancer statistics, 2016

1 reference

12 December 2020

The role of cullin 5-containing ubiquitin ligases

1 reference

12 December 2020

Copy-number variation of MCL1 predicts overall survival of non-small-cell lung cancer in a Southern Chinese population.

1 reference

12 December 2020

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis

1 reference

12 December 2020

Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.

1 reference

12 December 2020

The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation.

1 reference

12 December 2020

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

1 reference

12 December 2020

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

1 reference

12 December 2020

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

1 reference

12 December 2020

Production of Purified CasRNPs for Efficacious Genome Editing

1 reference

12 December 2020

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.

1 reference

12 December 2020

MCL-1 is a prognostic indicator and drug target in breast cancer

1 reference

12 December 2020

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

1 reference

12 December 2020

VDAC2 enables BAX to mediate apoptosis and limit tumor development

1 reference

12 December 2020

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

1 reference

12 December 2020

Identifiers

DOI

10.7554/ELIFE.44288

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31294695%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

1 reference

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24 April 2020

PubMed publication ID

31294695

1 reference