(Q83388021)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21302295%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Tiam1 is recruited to β1-integrin complexes by 14-3-3ζ where it mediates integrin-induced Rac1 activation and motility (English)

1 reference

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22 January 2020

2

Katarzyna Bialkowska

1 reference

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22 January 2020

author name string

Timothy E O'Toole

series ordinal

1

1 reference

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22 January 2020

Xiaohong Li

series ordinal

3

1 reference

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22 January 2020

Joan E B Fox

series ordinal

4

1 reference

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22 January 2020

publication date

1 November 2011

1 reference

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Journal of Cellular Physiology

22 January 2020

published in

1 reference

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22 January 2020

volume

226

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22 January 2020

page(s)

2965-2978

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22 January 2020

issue

11

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describes a project that uses

22 January 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6385608/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins

1 reference

12 December 2020

Rho GTPases control polarity, protrusion, and adhesion during cell movement

1 reference

12 December 2020

Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation

1 reference

12 December 2020

CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration

1 reference

12 December 2020

Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid

1 reference

12 December 2020

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

1 reference

12 December 2020

Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration

1 reference

12 December 2020

Signaling networks linking integrins and rho family GTPases.

1 reference

12 December 2020

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

1 reference

12 December 2020

Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1

1 reference

12 December 2020

Identification of a novel interaction between integrin beta1 and 14-3-3beta

1 reference

12 December 2020

Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway

1 reference

12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

12 December 2020

Vav2 is required for cell spreading

1 reference

12 December 2020

Identification of a novel interaction of 14-3-3 with p190RhoGEF.

1 reference

12 December 2020

Assembly and mechanosensory function of focal contacts

1 reference

12 December 2020

Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes

1 reference

12 December 2020

Molecular complexity and dynamics of cell-matrix adhesions

1 reference

12 December 2020

14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation

1 reference

12 December 2020

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

1 reference

12 December 2020

Networks and crosstalk: integrin signalling spreads.

1 reference

12 December 2020

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

1 reference

12 December 2020

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

1 reference

12 December 2020

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

1 reference

12 December 2020

Specificity of 14-3-3 isoform dimer interactions and phosphorylation

1 reference

12 December 2020

Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts

1 reference

12 December 2020

Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis

1 reference

12 December 2020

The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis

1 reference

12 December 2020

Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin

1 reference

12 December 2020

Cellular motility driven by assembly and disassembly of actin filaments

1 reference

12 December 2020

Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

1 reference

12 December 2020

14-3-3 zeta mediates integrin-induced activation of Cdc42 and Rac. Platelet glycoprotein Ib-IX regulates integrin-induced signaling by sequestering 14-3-3 zeta

1 reference

12 December 2020

Regulation of Tiam1-Rac signalling.

1 reference

12 December 2020

The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface

1 reference

12 December 2020

The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration

1 reference

12 December 2020

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.

1 reference

12 December 2020

Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy

1 reference

12 December 2020

Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1.

1 reference

12 December 2020

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor

1 reference

12 December 2020

The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression

1 reference

12 December 2020

Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

1 reference

12 December 2020

Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex

1 reference

12 December 2020

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

1 reference

12 December 2020

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils

1 reference

12 December 2020

Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion

1 reference

12 December 2020

Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors

1 reference

12 December 2020

Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta

1 reference

12 December 2020

Polarized downregulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow

1 reference

12 December 2020

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms

1 reference

12 December 2020

Structure and function of the platelet integrin alphaIIbbeta3

1 reference

12 December 2020

The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration

1 reference

12 December 2020

AlphaPIX and betaPIX and their role in focal adhesion formation

1 reference

12 December 2020

Activation of Rac1 by RhoG regulates cell migration

1 reference

12 December 2020

Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migration

1 reference

12 December 2020

Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.

1 reference

12 December 2020

Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms

1 reference

12 December 2020

14-3-3 proteins: a historic overview

1 reference

12 December 2020

Does isoform diversity explain functional differences in the 14-3-3 protein family?

1 reference

12 December 2020

Myosin-X is a molecular motor that functions in filopodia formation

1 reference

12 December 2020

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling

1 reference

12 December 2020

Phosphorylation of the LFA-1 Integrin β2-Chain on Thr-758 Leads to Adhesion, Rac-1/Cdc42 Activation, and Stimulation of CD69 Expression in Human T Cells

1 reference

12 December 2020

14-3-3 Proteins Bind Both Filamin and Lbeta2 Integrin in Activated T Cells

1 reference

12 December 2020

The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development

1 reference

12 December 2020

Functional atlas of the integrin adhesome

1 reference

12 December 2020

Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding.

1 reference

12 December 2020

The functional interaction of 14-3-3 proteins with the ERK1/2 scaffold KSR1 occurs in an isoform-specific manner.

1 reference

12 December 2020

Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

1 reference

12 December 2020

PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway

1 reference

12 December 2020

Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1.

1 reference

12 December 2020

A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation.

1 reference

12 December 2020

Dimerization is essential for 14-3-3zeta stability and function in vivo

1 reference

12 December 2020

Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells.

1 reference

12 December 2020

Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells

1 reference

12 December 2020

Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib

1 reference

12 December 2020

Role of phosphorylation in mediating the association of myosin with the cytoskeletal structures of human platelets

1 reference

12 December 2020

Down regulation of talin alters cell adhesion and the processing of the alpha 5 beta 1 integrin

1 reference

12 December 2020

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.

1 reference

12 December 2020

Inhibition of cell motility after nm23 transfection of human and murine tumor cells

1 reference

12 December 2020

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

1 reference

12 December 2020

The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.

1 reference

12 December 2020

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain

1 reference

12 December 2020

Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C.

1 reference

12 December 2020

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

12 December 2020

Integrin-mediated signals regulated by members of the rho family of GTPases

1 reference

12 December 2020

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

1 reference

12 December 2020

Identifiers

DOI

10.1002/JCP.22644

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21302295%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21302295%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference