(Q85007868)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Tumorigenesis in Down's syndrome: big lessons from a small chromosome (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

Dean Nižetić

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Jürgen Groet

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

publication date

21 September 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

page(s)

721-732

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc3355

13 February 2020

exact match

0 references

cites work

Prenatal screening for Down's syndrome: editorial responsibilities

1 reference

Changes in yearly birth prevalence rates of children with Down syndrome in the period 1986-2007 in The Netherlands.

31 March 2020

1 reference

How far can prenatal screening go in preventing birth defects?

31 March 2020

1 reference

Risks of leukaemia and solid tumours in individuals with Down's syndrome.

31 March 2020

1 reference

Simultaneous occurrence of mongolism and leukemia; report of a nationwide survey

31 March 2020

1 reference

Leukemia in Down syndrome: a review

31 March 2020

1 reference

Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

31 March 2020

1 reference

Incidence and treatment of potentially lethal diseases in transient leukemia of Down syndrome: Pediatric Oncology Group Study

31 March 2020

1 reference

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

31 March 2020

1 reference

Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker.

31 March 2020

1 reference

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

31 March 2020

1 reference

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

31 March 2020

1 reference

Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder

31 March 2020

1 reference

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

31 March 2020

1 reference

Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia.

31 March 2020

1 reference

Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group

31 March 2020

1 reference

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.

31 March 2020

1 reference

Intracranial germinoma with Down's syndrome: a case report and review of the literature

31 March 2020

1 reference

Cancers and immune related diseases associated with Down's syndrome: a record linkage study.

31 March 2020

1 reference

Pattern of malignant disorders in individuals with Down's syndrome.

31 March 2020

1 reference

Mortality and cancer incidence in persons with Down's syndrome, their parents and siblings

31 March 2020

1 reference

Mortality and cancer incidence among individuals with Down syndrome

31 March 2020

1 reference

Cancer incidence of persons with down syndrome in Finland: A population-based study

31 March 2020

1 reference

Testicular germ cell tumours: predisposition genes and the male germ cell niche.

31 March 2020

1 reference

Seminoma associated with bilateral cryptorchidism in Down's syndrome: a case report.

31 March 2020

1 reference

Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors

31 March 2020

1 reference

Incidence of leukemia and other cancers in Down syndrome subjects in Israel

31 March 2020

1 reference

Congenital malformations and childhood cancer

31 March 2020

1 reference

Leukemia and other Cancers, Anomalies and Infections as Causes of Death in Down's Syndrome in the United States during 1976

31 March 2020

1 reference

Mortality and causes of death in persons with Down syndrome in California

31 March 2020

1 reference

Are solid tumours different in children with Down's syndrome?

31 March 2020

1 reference

Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

31 March 2020

1 reference

Causes and consequences of aneuploidy in cancer.

31 March 2020

1 reference

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

31 March 2020

1 reference

Molecular cytogenetic characteristics of Down syndrome newborns

31 March 2020

1 reference

Telomere aggregates in trisomy 21 amniocytes

31 March 2020

1 reference

Increased low-level chromosome 21 mosaicism in older individuals with Down syndrome.

31 March 2020

1 reference

Age-associated chromosome 21 loss in Down syndrome: possible relevance to mosaicism and Alzheimer disease.

31 March 2020

1 reference

Low level chromosome instability in embryonic cells of primary aneuploid mice

31 March 2020

1 reference

Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13

31 March 2020

1 reference

Constitutional aneuploidy and cancer predisposition

31 March 2020

1 reference

Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study

31 March 2020

1 reference

Mortality and cancer incidence in persons with numerical sex chromosome abnormalities: a cohort study

31 March 2020

1 reference

Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study

31 March 2020

1 reference

ETS gene fusions in prostate cancer

31 March 2020

1 reference

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

31 March 2020

1 reference

Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia

31 March 2020

1 reference

Increased lipid peroxidation in Down's syndrome mouse models.

31 March 2020

1 reference

Reactive oxygen species generation in gingival fibroblasts of Down syndrome patients detected by electron spin resonance spectroscopy.

31 March 2020

1 reference

DNA damage and repair in children with Down's syndrome

31 March 2020

1 reference

Age-dependent oxidative stress-induced DNA damage in Down's lymphocytes.

31 March 2020

1 reference

Down's syndrome fibroblasts anticipate the accumulation of specific ageing-related mtDNA mutations

31 March 2020

1 reference

Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide.

31 March 2020

1 reference

Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis

31 March 2020

1 reference

Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome

31 March 2020

1 reference

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway.

31 March 2020

1 reference

Decreased repair of x-ray induced DNA single-strand breaks in lymphocytes in Down's syndrome

31 March 2020

1 reference

Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome

31 March 2020

1 reference

Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients.

31 March 2020

1 reference

Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome

31 March 2020

1 reference

Infections and immunodeficiency in Down syndrome

31 March 2020

1 reference

T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome).

31 March 2020

1 reference

Decreased AIRE expression and global thymic hypofunction in Down syndrome.

31 March 2020

1 reference

Down syndrome (DS) peripheral blood contains phenotypically mature CD3+TCR alpha, beta+ cells but abnormal proportions of TCR alpha, beta+, TCR gamma, delta+, and CD4+ CD45RA+ cells: evidence for an inefficient release of mature T cells by the DS th

31 March 2020

1 reference

Gammadelta T cells and the lymphoid stress-surveillance response

31 March 2020

1 reference

Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome

31 March 2020

1 reference

Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans.

31 March 2020

1 reference

High seroprevalence of Helicobacter pylori infection in non-institutionalised children with mental retardation.

31 March 2020

1 reference

Clinical audit of gastrointestinal conditions occurring among adults with Down syndrome attending a specialist clinic

31 March 2020

1 reference

Trisomy 21 as the only recurrent chromosomal anomaly in a clinically aggressive ovarian carcinoma

31 March 2020

1 reference

Acute lymphoblastic leukemia and chromosome 21.

31 March 2020

1 reference

Further correlations of morphology according to FAB and WHO classification to cytogenetics in de novo acute myeloid leukemia: a study on 2,235 patients.

31 March 2020

1 reference

Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance

31 March 2020

1 reference

The proto-oncogene ERG in megakaryoblastic leukemias

31 March 2020

1 reference

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia

31 March 2020

1 reference

ERG is a megakaryocytic oncogene.

31 March 2020

1 reference

ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells

31 March 2020

1 reference

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome

31 March 2020

1 reference

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

31 March 2020

1 reference

Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.

31 March 2020

1 reference

Chromosome 21 and down syndrome: from genomics to pathophysiology

31 March 2020

1 reference

Amplified segment in the 'Down syndrome critical region' on HSA21 shared between Down syndrome and euploid AML-M0 excludes RUNX1, ERG and ETS2

31 March 2020

1 reference

Genome wide molecular analysis of minimally differentiated acute myeloid leukemia

31 March 2020

1 reference

Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix

31 March 2020

1 reference

Proliferation dynamics in cultured skin fibroblasts from Down syndrome subjects

31 March 2020

1 reference

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

31 March 2020

1 reference

Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc.

31 March 2020

1 reference

ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

31 March 2020

1 reference

Ets-2 is induced by oxidative stress and sensitizes cells to H(2)O(2)-induced apoptosis: implications for Down's syndrome

31 March 2020

1 reference

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development

31 March 2020

1 reference

Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells

31 March 2020

1 reference

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

31 March 2020

1 reference

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

31 March 2020

1 reference

DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome

31 March 2020

1 reference

A genetic screen for candidate tumor suppressors identifies REST

31 March 2020

1 reference

Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer

31 March 2020

1 reference

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis

31 March 2020

1 reference

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome.

31 March 2020

1 reference

REST regulates DYRK1A transcription in a negative feedback loop

31 March 2020

1 reference

p53 downregulates Down syndrome-associated DYRK1A through miR-1246.

31 March 2020

1 reference

DYRK1A in Down syndrome: an oncogene or tumor suppressor?

31 March 2020

1 reference

High serum endostatin levels in Down syndrome: implications for improved treatment and prevention of solid tumours

31 March 2020

1 reference

Phase I study of recombinant human endostatin in patients with advanced solid tumors

31 March 2020

1 reference

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

31 March 2020

1 reference

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

31 March 2020

1 reference

Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome

31 March 2020

1 reference

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

31 March 2020

1 reference

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

31 March 2020

1 reference

Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome

31 March 2020

1 reference

Fetal cervico-mediastinal cystic hygroma associated with maternal serum screening positive for Down syndrome

31 March 2020

1 reference

Extragonadal choriocarcinoma in a patient with Down syndrome.

31 March 2020

1 reference

Tuberous sclerosis with intracardiac rhabdomyoma in a fetus with trisomy 21: case report and review of literature

31 March 2020

1 reference

Pineal yolk sac tumour with a solid pattern: a case report in a Chinese adult man with Down's syndrome

31 March 2020

1 reference

Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome

31 March 2020

1 reference

Prenatal origin of acute lymphoblastic leukaemia in children

31 March 2020

1 reference

What is the true fetal loss rate in pregnancies affected by trisomy 21 and how does this influence whether first trimester detection rates are superior to those in the second trimester?

31 March 2020

1 reference

Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance

31 March 2020

1 reference

An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model

31 March 2020

1 reference

Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study

31 March 2020

1 reference

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

31 March 2020

1 reference

Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors.

31 March 2020

1 reference

Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome

31 March 2020

1 reference

Trisomy 21 enhances human fetal erythro-megakaryocytic development

31 March 2020

1 reference

Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations

31 March 2020

1 reference

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1

31 March 2020

1 reference

Megakaryocyte hyperproliferation without GATA1 mutation in foetal liver of a case of Down syndrome with hydrops foetalis

31 March 2020

1 reference

Myeloid proliferation without GATA1 mutations in a fetus with Down syndrome presenting in utero as a pericardial effusion

31 March 2020

1 reference

Hematological abnormalities during the first week of life among neonates with Down syndrome: data from a multihospital healthcare system

31 March 2020

1 reference

Loss-of-function JAK3 mutations in TMD and AMKL of Down syndrome

31 March 2020

1 reference

Independent clones at separable stages of differentiation, bearing different GATA1 mutations, in the same TMD patient with Down syndrome.

31 March 2020

1 reference

Activating alleles of JAK3 in acute megakaryoblastic leukemia

31 March 2020

1 reference

Hematopoietic progenitor cell deficiency in fetuses and children affected by Down's syndrome

31 March 2020

1 reference

Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress

31 March 2020

1 reference

Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?

31 March 2020

1 reference

Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.

31 March 2020

1 reference

The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls

31 March 2020

1 reference

Transcription factor GATA-1 and Down syndrome leukemogenesis

31 March 2020

1 reference

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

1 reference

A DNA damage checkpoint response in telomere-initiated senescence

31 March 2020

1 reference

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

1 reference

DNA damage foci at dysfunctional telomeres

31 March 2020

1 reference

DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

31 March 2020

1 reference

Immune dysfunction in Down's syndrome: primary immune deficiency or early senescence of the immune system?

31 March 2020

1 reference

Bone mineral density and respiratory muscle strength in male individuals with mental retardation (with and without Down Syndrome).

31 March 2020

1 reference

31 March 2020

1 reference

Leukemogenesis and ageing: 'fit for transformation'?

31 March 2020

1 reference

An E mu-BCL-2 transgene facilitates leukaemogenesis by ionizing radiation

31 March 2020

1 reference

Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987.

31 March 2020

2 references

31 March 2020

12 December 2020

Incidence of female breast cancer among atomic bomb survivors, 1950-1985

1 reference

Genetic variegation of clonal architecture and propagating cells in leukaemia

31 March 2020

1 reference

Hematological abnormalities in adult patients with Down's syndrome

31 March 2020

1 reference

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

31 March 2020

1 reference

Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.

31 March 2020

1 reference

RAS is regulated by the let-7 microRNA family

31 March 2020

1 reference

Analysis of the ANA gene as a candidate for the chromosome 21q oral cancer susceptibility locus

31 March 2020

1 reference

Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

31 March 2020

1 reference

Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment

31 March 2020

1 reference

Chromosome translocations and covert leukemic clones are generated during normal fetal development

31 March 2020

1 reference

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia

31 March 2020

1 reference

Ha-Ras transformation of MCF10A cells leads to repression of Singleminded-2s through NOTCH and C/EBPbeta.

31 March 2020

1 reference

Stem cell gene expression programs influence clinical outcome in human leukemia.

31 March 2020

1 reference

EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma.

31 March 2020

1 reference

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

31 March 2020

1 reference

Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein

31 March 2020

1 reference

An ovarian dysgerminoma in Down syndrome. Hypothesis about the association

31 March 2020

1 reference

12 December 2020

High frequency of copy number alterations in myeloid leukaemia of Down syndrome.

1 reference

12 December 2020

Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment.

1 reference

12 December 2020

Persons with Down syndrome in residential care in Israel: trends for 1998-2006.

1 reference

12 December 2020

A lack of neuroblastoma in Down syndrome: a study from 11 European countries

1 reference

12 December 2020

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes

1 reference

12 December 2020

Aneuploidy, the somatic mutation that makes cancer a species of its own.

1 reference

12 December 2020

MiR-125 in normal and malignant hematopoiesis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3355

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22996602%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 February 2020

0 references

1 reference