(Q88355598)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29654217%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

The role of mitochondria in stem cell fate and aging (English)

1 reference

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23 March 2020

1

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23 March 2020

Johan Auwerx

series ordinal

3

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23 March 2020

author name string

Keir J Menzies

series ordinal

2

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23 March 2020

publication date

13 April 2018

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23 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29654217%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

volume

145

1 reference

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23 March 2020

issue

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29654217%20AND%20SRC:MED&resulttype=core&format=json

Low oxygen concentration extends the lifespan of cultured human diploid cells

23 March 2020

cites work

1 reference

12 December 2020

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1 reference

12 December 2020

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging.

1 reference

12 December 2020

The biologic clock: the mitochondria?

1 reference

12 December 2020

The aging of hematopoietic stem cells

1 reference

12 December 2020

Age changes in stem cells of murine small intestinal crypts

1 reference

12 December 2020

Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells.

1 reference

12 December 2020

Age-associated characteristics of murine hematopoietic stem cells

1 reference

12 December 2020

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

1 reference

12 December 2020

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

1 reference

12 December 2020

The role of stem cells in aging

1 reference

12 December 2020

Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction

1 reference

12 December 2020

Mitochondrial DNA mutations in human colonic crypt stem cells

1 reference

12 December 2020

Cancer metabolism: facts, fantasy, and fiction

1 reference

12 December 2020

Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice.

1 reference

12 December 2020

Premature ageing in mice expressing defective mitochondrial DNA polymerase

1 reference

12 December 2020

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

1 reference

12 December 2020

Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche

1 reference

12 December 2020

Low O2 tensions and the prevention of differentiation of hES cells

1 reference

12 December 2020

Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity.

1 reference

12 December 2020

Cell intrinsic alterations underlie hematopoietic stem cell aging.

1 reference

12 December 2020

Clustering of mutant mitochondrial DNA copies suggests stem cells are common in human bronchial epithelium

1 reference

12 December 2020

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

1 reference

12 December 2020

The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells

1 reference

12 December 2020

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

1 reference

12 December 2020

Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells

1 reference

12 December 2020

High oxidative damage levels in the longest-living rodent, the naked mole-rat

1 reference

12 December 2020

Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells

1 reference

12 December 2020

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

1 reference

12 December 2020

Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway.

1 reference

12 December 2020

DNA damage, cellular senescence and organismal ageing: causal or correlative?

1 reference

12 December 2020

Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells

1 reference

12 December 2020

Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells

1 reference

12 December 2020

1 reference

12 December 2020

JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut.

1 reference

12 December 2020

Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells

1 reference

12 December 2020

Bmi1 regulates mitochondrial function and the DNA damage response pathway

1 reference

12 December 2020

ATP-citrate lyase links cellular metabolism to histone acetylation

1 reference

12 December 2020

Hypoxia enhances the generation of induced pluripotent stem cells

1 reference

12 December 2020

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction

1 reference

12 December 2020

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

1 reference

12 December 2020

Carbon metabolism-mediated myogenic differentiation

1 reference

12 December 2020

PTEN inhibition improves muscle regeneration in mice fed a high-fat diet

1 reference

12 December 2020

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells

1 reference

12 December 2020

Metabolic oxidation regulates embryonic stem cell differentiation

1 reference

12 December 2020

Dietary restriction enhances germline stem cell maintenance

1 reference

12 December 2020

Mitochondrial dysfunction in obesity

1 reference

12 December 2020

Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells

1 reference

12 December 2020

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini

1 reference

12 December 2020

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

1 reference

12 December 2020

Histone methyl transferases and demethylases; can they link metabolism and transcription?

1 reference

12 December 2020

Epigenetic modifications and human disease

1 reference

12 December 2020

Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells

1 reference

12 December 2020

A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans

1 reference

12 December 2020

The cell-non-autonomous nature of electron transport chain-mediated longevity

1 reference

12 December 2020

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging

1 reference

12 December 2020

Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation

1 reference

12 December 2020

Mitochondrial DNA damage level determines neural stem cell differentiation fate.

1 reference

12 December 2020

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

1 reference

12 December 2020

Impaired muscle regeneration in ob/ob and db/db mice

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12 December 2020

Reduced oxygen concentration enhances conversion of embryonic stem cells to epiblast stem cells.

1 reference

12 December 2020

Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism

1 reference

12 December 2020

Metabolic state of glioma stem cells and nontumorigenic cells

1 reference

12 December 2020

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

1 reference

12 December 2020

Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.

1 reference

12 December 2020

Mitochondrial complex III ROS regulate adipocyte differentiation

1 reference

12 December 2020

Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.

1 reference

12 December 2020

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.

1 reference

12 December 2020

Autophagy is required for self-renewal and differentiation of adult human stem cells

1 reference

12 December 2020

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

1 reference

12 December 2020

Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

1 reference

12 December 2020

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

1 reference

12 December 2020

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

1 reference

12 December 2020

Energy metabolism plasticity enables stemness programs

1 reference

12 December 2020

Short-term calorie restriction enhances skeletal muscle stem cell function

1 reference

12 December 2020

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

1 reference

12 December 2020

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

1 reference

12 December 2020

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

1 reference

12 December 2020

Influence of threonine metabolism on S-adenosylmethionine and histone methylation

1 reference

12 December 2020

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

1 reference

12 December 2020

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells

1 reference

12 December 2020

Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation

1 reference

12 December 2020

SIRT3 reverses aging-associated degeneration

1 reference

12 December 2020

FOXO3A directs a protective autophagy program in haematopoietic stem cells.

1 reference

12 December 2020

Mechanisms that regulate stem cell aging and life span

1 reference

12 December 2020

Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate

1 reference

12 December 2020

Pharmacological approaches to restore mitochondrial function

1 reference

12 December 2020

Mitonuclear protein imbalance as a conserved longevity mechanism

1 reference

12 December 2020

Polycomb complexes in stem cells and embryonic development.

1 reference

12 December 2020

Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.

1 reference

12 December 2020

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

1 reference

12 December 2020

Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells

1 reference

12 December 2020

Muscle mitohormesis promotes longevity via systemic repression of insulin signaling

1 reference

12 December 2020

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

1 reference

12 December 2020

Derivation of naive human embryonic stem cells.

1 reference

12 December 2020

Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.

1 reference

12 December 2020

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

1 reference

12 December 2020

Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

1 reference

12 December 2020

Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.

1 reference

12 December 2020

Mitochondrial proteostasis in the control of aging and longevity

1 reference

12 December 2020

Stem cell aging: mechanisms, regulators and therapeutic opportunities

1 reference

12 December 2020

Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells

1 reference

12 December 2020

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

1 reference

12 December 2020

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

1 reference

12 December 2020

Stem cells and the impact of ROS signaling

1 reference

12 December 2020

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.

1 reference

12 December 2020

Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling

1 reference

12 December 2020

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

1 reference

12 December 2020

In vivo single-cell detection of metabolic oscillations in stem cells

1 reference

12 December 2020

The mitochondrial unfolded protein response—synchronizing genomes

1 reference

12 December 2020

The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells

1 reference

12 December 2020

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.

1 reference

12 December 2020

Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.

1 reference

12 December 2020

Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

1 reference

12 December 2020

Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

1 reference

12 December 2020

ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency

1 reference

12 December 2020

Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming.

1 reference

12 December 2020

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling

1 reference

12 December 2020

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

1 reference

12 December 2020

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

1 reference

12 December 2020

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

1 reference

12 December 2020

Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain

1 reference

12 December 2020

Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

1 reference

12 December 2020

Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming

1 reference

12 December 2020

Protein acetylation in metabolism - metabolites and cofactors

1 reference

12 December 2020

Measuring In Vivo Mitophagy

1 reference

12 December 2020

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

1 reference

12 December 2020

Metabolic control of methylation and acetylation

1 reference

12 December 2020

Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation.

1 reference

12 December 2020

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.

1 reference

12 December 2020

Autophagy maintains stemness by preventing senescence

1 reference

12 December 2020

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila

1 reference

12 December 2020

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

1 reference

12 December 2020

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

1 reference

12 December 2020

Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency.

1 reference

12 December 2020

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

1 reference

12 December 2020

The Mitochondrial Basis of Aging

1 reference

12 December 2020

Metabolism and the UPR(mt).

1 reference

12 December 2020

Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

1 reference

12 December 2020

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

1 reference

12 December 2020

1 reference

12 December 2020

Mitochondrial aerobic respiration is activated during hair follicle stem cell differentiation, and its dysfunction retards hair regeneration

1 reference

12 December 2020

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

1 reference

12 December 2020

1 reference

12 December 2020

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

1 reference

12 December 2020

Systems proteomics of liver mitochondria function

1 reference

12 December 2020

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.

1 reference

12 December 2020

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

1 reference

12 December 2020

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction.

1 reference

12 December 2020

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.

1 reference

12 December 2020

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation.

1 reference

12 December 2020

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

1 reference

12 December 2020

Mitochondrial function controls intestinal epithelial stemness and proliferation

1 reference

12 December 2020

Metabolic regulation of gene expression through histone acylations

1 reference

12 December 2020

Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1.

1 reference

12 December 2020

Rejuvenating stem cells to restore muscle regeneration in aging

1 reference

12 December 2020

Metabolic remodeling during the loss and acquisition of pluripotency.

1 reference

12 December 2020

Autophagy maintains the metabolism and function of young and old stem cells.

1 reference

12 December 2020

Interplay between metabolic identities in the intestinal crypt supports stem cell function

1 reference

12 December 2020

Mitochondria and Epigenetics - Crosstalk in Homeostasis and Stress

1 reference

12 December 2020

The mitochondrial respiratory chain is essential for haematopoietic stem cell function.

1 reference

12 December 2020

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

1 reference

12 December 2020

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis.

1 reference

12 December 2020

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

1 reference

12 December 2020

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.

1 reference

12 December 2020

Repairing Mitochondrial Dysfunction in Disease

1 reference

12 December 2020

Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells

1 reference

12 December 2020

Identifiers

DOI

10.1242/DEV.143420

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29654217%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29654217%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

PubMed publication ID

29654217

1 reference