(Q88623053)

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26 March 2020

title

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis (English)

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26 March 2020

1 reference

1 reference

1

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26 March 2020

Garrett A Sessions

2

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26 March 2020

John A Collins

3

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26 March 2020

Cathy S Carlson

7

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26 March 2020

Richard F Loeser

8

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26 March 2020

Norman Sharpless

9

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26 March 2020

author name string

Anne K Knecht

4

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26 March 2020

Susan L Strum

5

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26 March 2020

Natalia K Mitin

6

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26 March 2020

publication date

9 May 2018

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26 March 2020

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26 March 2020

volume

17

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26 March 2020

issue

4

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26 March 2020

page(s)

e12771

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

26 March 2020

cites work

1 reference

12 December 2020

Stage-and tissue-specific expression of a Col2a1-Cre fusion gene in transgenic mice

1 reference

12 December 2020

Telomere erosion and senescence in human articular cartilage chondrocytes.

1 reference

12 December 2020

Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee

1 reference

12 December 2020

The role of chondrocyte senescence in osteoarthritis

1 reference

12 December 2020

The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes

1 reference

12 December 2020

Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro

1 reference

12 December 2020

Ink4a/Arf expression is a biomarker of aging

1 reference

12 December 2020

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

1 reference

12 December 2020

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

1 reference

12 December 2020

p16INK4a induces an age-dependent decline in islet regenerative potential

1 reference

12 December 2020

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

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12 December 2020

The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse

1 reference

12 December 2020

Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation

1 reference

12 December 2020

Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging

1 reference

12 December 2020

Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage

1 reference

12 December 2020

The senescence-associated secretory phenotype: the dark side of tumor suppression

1 reference

12 December 2020

Cartilage cell clusters.

1 reference

12 December 2020

Somatic p16(INK4a) loss accelerates melanomagenesis

1 reference

12 December 2020

Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes

1 reference

12 December 2020

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype

1 reference

12 December 2020

Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice

1 reference

12 December 2020

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

1 reference

12 December 2020

DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes

1 reference

12 December 2020

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

1 reference

12 December 2020

p16(INK4a) exerts an anti-inflammatory effect through accelerated IRAK1 degradation in macrophages.

1 reference

12 December 2020

Aging processes and the development of osteoarthritis

1 reference

12 December 2020

Geriatric muscle stem cells switch reversible quiescence into senescence.

1 reference

12 December 2020

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis.

1 reference

12 December 2020

Mouse models of osteoarthritis: modelling risk factors and assessing outcomes.

1 reference

12 December 2020

Cellular senescence: from physiology to pathology

1 reference

12 December 2020

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

1 reference

12 December 2020

Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice

1 reference

12 December 2020

Identification of a Prg4-expressing articular cartilage progenitor cell population in mice

1 reference

12 December 2020

A Comprehensive Histological Assessment of Osteoarthritis Lesions in Mice

1 reference

12 December 2020

Forging a signature of in vivo senescence

1 reference

12 December 2020

Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration

1 reference

12 December 2020

Cellular senescence in aging and age-related disease: from mechanisms to therapy

1 reference

12 December 2020

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

1 reference

12 December 2020

Ageing and the pathogenesis of osteoarthritis.

1 reference

12 December 2020

Identification of Senescent Cells in the Bone Microenvironment

1 reference

12 December 2020

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

1 reference

12 December 2020

Reduced Osteoarthritis Severity in Aged Mice With Deletion of Macrophage Migration Inhibitory Factor

1 reference

12 December 2020

Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging

1 reference

12 December 2020

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

1 reference

12 December 2020

Cellular senescence in osteoarthritis pathology.

1 reference

12 December 2020

Cell cycle proteins as promising targets in cancer therapy

1 reference

12 December 2020

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

1 reference

12 December 2020

Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs

1 reference

12 December 2020

Senescence in Health and Disease.

1 reference

12 December 2020

CDK4/6 inhibition triggers anti-tumour immunity.

1 reference

12 December 2020

Targeting cellular senescence prevents age-related bone loss in mice.

1 reference

12 December 2020

The Clinical Potential of Senolytic Drugs

1 reference

12 December 2020

Targeting aging for disease modification in osteoarthritis

1 reference

12 December 2020

Identifiers

DOI

10.1111/ACEL.12771

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744983%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

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26 March 2020

PubMed publication ID

29744983

1 reference