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English
Ageing and the pathogenesis of osteoarthritis.
scientific article published on 19 May 2016
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
review article
1 reference
stated in
Europe PubMed Central
title
Ageing and the pathogenesis of osteoarthritis
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
main subject
pathogenesis
0 references
osteoarthritis
0 references
author
Brian O Diekman
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
Richard F Loeser
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1
object named as
Richard F Loeser
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
author name string
John A Collins
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
language of work or name
English
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publication date
19 May 2016
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Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
published in
Nature Reviews Rheumatology
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
volume
12
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
issue
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
page(s)
412-420
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Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
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Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI.
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Longitudinal study of muscle strength, quality, and adipose tissue infiltration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Growth stimulation leads to cellular senescence when the cell cycle is blocked
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Sirtuins in mammals: insights into their biological function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Basic FGF mediates an immediate response of articular cartilage to mechanical injury
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Inflamm-aging. An evolutionary perspective on immunosenescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Interleukin-6: a cytokine for gerontologists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
29 September 2017
Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
27 June 2018
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
27 June 2018
Aging and osteoarthritis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
27 June 2018
Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
27 June 2018
Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
27 June 2018
Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
27 June 2018
Economics of osteoarthritis: a global perspective
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
27 June 2018
Establishment of a rabbit model to study the influence of advanced glycation end products accumulation on osteoarthritis and the protective effect of pioglitazone.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Ageing is associated with reduction of mechanically-induced activation of Smad2/3P signaling in articular cartilage.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Editorial: inflammatory activity in symptomatic knee osteoarthritis: not all inflammation is local
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Inflamm-aging does not simply reflect increases in pro-inflammatory markers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Transient activation of p53 in G2 phase is sufficient to induce senescence.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Necessary and sufficient role for a mitosis skip in senescence induction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Is osteoarthritis a metabolic disease?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938009
retrieved
4 September 2018
Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRRHEUM.2016.65
retrieved
31 March 2020
Infrapatellar fat pad of patients with end-stage osteoarthritis inhibits catabolic mediators in cartilage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRRHEUM.2016.65
retrieved
31 March 2020
DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRRHEUM.2016.65
retrieved
31 March 2020
The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRRHEUM.2016.65
retrieved
31 March 2020
Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRRHEUM.2016.65
retrieved
31 March 2020
Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27192932
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NRRHEUM.2016.65
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
PMC publication ID
4938009
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
PubMed publication ID
27192932
1 reference
stated in
Europe PubMed Central
PMC publication ID
4938009
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
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