(Q97553514)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

title

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

1 reference

1 reference

1 reference

1 reference

1 reference

1

Andrea J Pruijssers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

29

Timothy P Sheahan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

27

Ralph S Baric

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

8

Maria L Agostini

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

28

Mark R Denison

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

10

James D Chappell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

26

Tomas Cihlar

1 reference

20 July 2020

4

Sarah R Leist

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

13

Kendra Gully

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

15

Ariane J Brown

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

5

Lisa E Gralinksi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

7

Boyd L Yount

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

3

Alexandra Schäfer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

9

Laura J Stevens

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

14

David R Martinez

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

2

Amelia S George

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

12

Tia M Hughes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

16

Rachel L Graham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

17

Jason K Perry

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

6

Kenneth H Dinnon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

18

Venice Du Pont

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

19

Jared Pitts

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

21

Darius Babusis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

22

Eisuke Murakami

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

23

Joy Y Feng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

24

John P Bilello

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

author name string

Xiaotao Lu

series ordinal

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

Bin Ma

series ordinal

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

Danielle P Porter

series ordinal

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

publication date

7 July 2020

1 reference

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20 July 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

page(s)

107940

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

20 July 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Remdesivir for the Treatment of Covid-19 — Final Report

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Compassionate Use of Remdesivir for Patients with Severe Covid-19

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Virological assessment of hospitalized patients with COVID-2019

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with 2019 Novel Coronavirus Disease, United States

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Viral load of SARS-CoV-2 in clinical samples

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

A pneumonia outbreak associated with a new coronavirus of probable bat origin

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

First Case of 2019 Novel Coronavirus in the United States

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Small-Molecule Antiviral β-d--Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Data, disease and diplomacy: GISAID's innovative contribution to global health

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Cell-line dependent antiviral activity of sofosbuvir against Zika virus

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

The ProTide Prodrug Technology: From the Concept to the Clinic

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

GISAID: Global initiative on sharing all influenza data - from vision to reality

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Middle East Respiratory Syndrome.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

SARS and MERS: recent insights into emerging coronaviruses

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

SARS-like WIV1-CoV poised for human emergence

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

New Metrics for Evaluating Viral Respiratory Pathogenesis

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Is the expression of deoxynucleoside kinases and 5'-nucleotidases in animal tissues related to the biological effects of nucleoside analogs?

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

The role of transporters in the toxicity of nucleoside and nucleotide analogs

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Severe acute respiratory syndrome

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Viral loads in clinical specimens and SARS manifestations.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Well-differentiated human airway epithelial cell cultures.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7340027

10.1016/J.CELREP.2020.107940

10 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32668216%20AND%20SRC:MED&resulttype=core&format=json

20 July 2020

PubMed publication ID

32668216

1 reference