(Q26269843)

GOA release 2020-03-11

author

Thomas C. Südhof

3

0 references

Sang Hun Lee

object named as

Sang Hun Lee

1

0 references

Manu Sharma

2

object named as

Manu Sharma

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author name string

Jie Shen

Proceedings of the National Academy of Sciences of the United States of America

4

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language of work or name

English

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publication date

17 June 2014

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published in

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volume

111

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issue

24

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page(s)

8973-8

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describes a project that uses

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4066509/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Presenilins are essential for regulating neurotransmitter release

7 April 2017

1 reference

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Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration

7 April 2017

1 reference

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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

7 April 2017

1 reference

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

7 April 2017

1 reference

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γ-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis

7 April 2017

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

7 April 2017

1 reference

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

7 April 2017

1 reference

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Skeletal and CNS defects in Presenilin-1-deficient mice

7 April 2017

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

7 April 2017

1 reference

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Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

7 April 2017

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APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

7 April 2017

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Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

7 April 2017

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Presenilin-1 regulates neuronal differentiation during neurogenesis

7 April 2017

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

7 April 2017

1 reference

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Essential functions of synapsins I and II in synaptic vesicle regulation

7 April 2017

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Notch1 functions as a tumor suppressor in mouse skin

7 April 2017

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Long-term potentiation--a decade of progress?

7 April 2017

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Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production.

7 April 2017

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Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins

28 September 2017

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28 September 2017

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A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity

28 September 2017

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28 September 2017

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ER calcium and Alzheimer's disease: in a state of flux

28 September 2017

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Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase

28 September 2017

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28 September 2017

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Augmentation is a potentiation of the exocytotic process

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Notch1 is essential for postimplantation development in mice.

31 May 2018

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Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model

31 May 2018

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Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

21 January 2018

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Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons

21 January 2018

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The NMDA-to-AMPA ratio at synapses onto layer 2/3 pyramidal neurons is conserved across prefrontal and visual cortices

21 January 2018

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21 January 2018

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Gamma-secretase gene mutations in familial acne inversa

21 January 2018

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A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa

21 January 2018

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Two novel mutations of the nicastrin gene in Chinese patients with acne inversa

21 January 2018

1 reference

PubMed

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