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Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
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scholarly article
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review article
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title
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
(English)
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main subject
hypoxia
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author name string
Caroline Wigerup
series ordinal
1
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Sven Påhlman
series ordinal
2
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Daniel Bexell
series ordinal
3
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language of work or name
English
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publication date
August 2016
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published in
Pharmacology & Therapeutics
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volume
164
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page(s)
152-69
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cites work
Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis.
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Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
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Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma
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Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients
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Hypoxia inducible factor-1alpha is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response
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Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X.
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Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours
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A group of novel HIF-1α inhibitors, glyceollins, blocks HIF-1α synthesis and decreases its stability via inhibition of the PI3K/AKT/mTOR pathway and Hsp90 binding
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High levels of HIF-2α highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche
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Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma
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Phase 1 evaluation of EZN-2208, a polyethylene glycol conjugate of SN38, in children adolescents and young adults with relapsed or refractory solid tumors
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Endogenous hypoxia markers: case not proven!
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A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma
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Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters
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A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination.
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Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors
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Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs
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Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice.
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Hypoxia inducible factor-1α correlates with VEGF-C expression and lymphangiogenesis in breast cancer
1 reference
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https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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inferred from DOI database lookup
Hypoxia in cancer: significance and impact on clinical outcome
1 reference
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https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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Targeting hypoxia cell signaling for cancer therapy
1 reference
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A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer
1 reference
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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors
1 reference
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7 January 2021
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Murine models and cell lines for the investigation of pheochromocytoma: applications for future therapies?
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Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix
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Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
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https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
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inferred from DOI database lookup
Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
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Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading
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7 January 2021
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Hif-1α and Hif-2α differentially regulate Notch signaling through competitive interaction with the intracellular domain of Notch receptors in glioma stem cells
1 reference
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7 January 2021
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2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2
1 reference
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7 January 2021
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inferred from DOI database lookup
Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
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inferred from DOI database lookup
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
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inferred from DOI database lookup
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
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inferred from DOI database lookup
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factors, stem cells, and cancer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hallmarks of Cancer: The Next Generation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
based on heuristic
inferred from DOI database lookup
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia requires notch signaling to maintain the undifferentiated cell state
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF targets in bone remodeling and metastatic disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
based on heuristic
inferred from DOI database lookup
The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
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7 January 2021
based on heuristic
inferred from DOI database lookup
Passing the baton: the HIF switch
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-2alpha expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia Attenuates the Expression of E-Cadherin via Up-Regulation of SNAIL in Ovarian Carcinoma Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor hypoxia and malignant progression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Significant correlation of hypoxia-inducible factor-1alpha with treatment outcome in cervical cancer treated with radical radiotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of hypoxia-activated prodrugs in cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one surgical cohort study
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of chemokine receptors in breast cancer metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies with bleomycin and misonidazole on aerated and hypoxic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia signalling in cancer and approaches to enforce tumour regression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An oxygen-regulated switch in the protein synthesis machinery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct regulation of TWIST by HIF-1alpha promotes metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of the VHL tumour suppressor gene in renal carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting HIF-1 for cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exploiting tumour hypoxia in cancer treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interplay between MYC and HIF in cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
VEGF-targeted therapy: mechanisms of anti-tumour activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The impact of O2 availability on human cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting hypoxia in cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deconvoluting the context-dependent role for autophagy in cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunity, inflammation and cancer: a leading role for adenosine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
bHLH-PAS proteins in cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxygen sensing by HIF hydroxylases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Relationship of hypoxia to metastatic ability in rodent tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Artificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Digoxin, HIF-1, and cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human cancers converge at the HIF-2alpha oncogenic axis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted expression of MYCN causes neuroblastoma in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1 alpha is required for solid tumor formation and embryonic vascularization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumoral EPAS1 (HIF2A) mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prognostic Significance of Hypoxia-Inducible Factor Expression in Renal Cell Carcinoma: A PRISMA-compliant Systematic Review and Meta-Analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human cancer growth and therapy in immunodeficient mouse models
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Downregulating hypoxia-inducible factor-2α improves the efficacy of doxorubicin in the treatment of hepatocellular carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
EO9 (Apaziquone): from the clinic to the laboratory and back again
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of HIF-1 inhibitors for cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Understanding the Warburg effect: the metabolic requirements of cell proliferation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Release of dopamine and norepinephrine by hypoxia from PC-12 cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MicroRNA regulation of DNA repair gene expression in hypoxic stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Collagen prolyl hydroxylases are essential for breast cancer metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-Inducible Factor-1 Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pseudohypoxic pathways in renal cell carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular pathways: hypoxia response in immune cells fighting or promoting cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RARα and PLZF-RARα-Driven Leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metastatic pheochromocytoma/paraganglioma related to primary tumor development in childhood or adolescence: significant link to SDHB mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase III randomized trial of weekly cisplatin and irradiation versus cisplatin and tirapazamine and irradiation in stages IB2, IIA, IIB, IIIB, and IVA cervical carcinoma limited to the pelvis: a Gynecologic Oncology Group study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Succinate Dehydrogenase B Gene Mutations Predict Survival in Patients with Malignant Pheochromocytomas or Paragangliomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
First report of bilateral pheochromocytoma in the clinical spectrum of HIF2A-related polycythemia-paraganglioma syndrome.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Warburg effect is genetically determined in inherited pheochromocytomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The histone deacetylase inhibitor, Vorinostat, represses hypoxia inducible factor 1 alpha expression through translational inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia inducible factor-2alpha in cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.PHARMTHERA.2016.04.009
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/J.PHARMTHERA.2016.04.009
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
481422
OpenCitations bibliographic resource ID
481422
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
481422
PubMed ID
27139518
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
481422
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