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Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
title
Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
main subject
sirolimus
1 reference
based on heuristic
inferred from title
author
Dudley W Lamming
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
author name string
Dudley W Lamming
series ordinal
1
0 references
language of work or name
English
0 references
publication date
2 May 2016
1 reference
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
published in
Cold Spring Harbor Perspectives in Medicine
1 reference
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
volume
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
issue
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
page(s)
a025924
0 references
cites work
mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity
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PubMed Central
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7 April 2017
Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
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7 April 2017
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
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PubMed Central
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7 April 2017
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
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PubMed Central
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7 April 2017
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
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PubMed Central
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7 April 2017
Efficacy and safety of sirolimus in lymphangioleiomyomatosis
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Activation of mTORC2 by association with the ribosome
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7 April 2017
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
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PubMed Central
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7 April 2017
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
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PubMed Central
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7 April 2017
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
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PubMed Central
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7 April 2017
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
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7 April 2017
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Extension of chronological life span in yeast by decreased TOR pathway signaling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Phosphorylation of Akt at the C-terminal tail triggers Akt activation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Regulation of mTORC1 by amino acids
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
STAT6-dependent and -independent mechanisms in Th2 polarization
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PubMed Central
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7 April 2017
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.
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PubMed Central
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7 April 2017
Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib
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7 April 2017
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.
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7 April 2017
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
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7 April 2017
The Roles of mTOR Complexes in Lipid Metabolism
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PubMed Central
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7 April 2017
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Haploinsufficiency of akt1 prolongs the lifespan of mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Rapalogs and mTOR inhibitors as anti-aging therapeutics
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
1 reference
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PubMed Central
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7 April 2017
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
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7 April 2017
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
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7 April 2017
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
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7 April 2017
Genetics: influence of TOR kinase on lifespan in C. elegans
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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7 April 2017
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
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PubMed Central
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7 April 2017
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
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PubMed Central
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28 September 2017
Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model
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28 September 2017
Promoting health and longevity through diet: from model organisms to humans
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28 September 2017
Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice.
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28 September 2017
Rapamycin-induced metabolic defects are reversible in both lean and obese mice
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PubMed Central
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28 September 2017
mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity
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PubMed Central
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28 September 2017
Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset
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28 September 2017
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
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28 September 2017
The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice
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28 September 2017
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
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28 September 2017
Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver
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28 September 2017
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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28 September 2017
XPLN is an endogenous inhibitor of mTORC2.
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28 September 2017
The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1
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PubMed Central
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28 September 2017
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
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28 September 2017
Remodeling of lipid metabolism by dietary restriction of essential amino acids
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28 September 2017
Rapamycin extends murine lifespan but has limited effects on aging
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PubMed Central
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28 September 2017
Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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28 September 2017
Rapamycin extends life and health in C57BL/6 mice
1 reference
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PubMed Central
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28 September 2017
Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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28 September 2017
Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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28 September 2017
mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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28 September 2017
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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28 September 2017
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
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28 September 2017
Rapamycin slows aging in mice
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
A unifying model for mTORC1-mediated regulation of mRNA translation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Regulation of immune responses by mTOR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Leucine nutrition in animals and humans: mTOR signaling and beyond
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Role of autophagy in suppression of inflammation and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Sirolimus is associated with new-onset diabetes in kidney transplant recipients.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Autophagy and aging: the importance of maintaining "clean" cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 September 2017
The TSC-mTOR pathway regulates macrophage polarization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
31 May 2018
Pet dogs set to test anti-ageing drug.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
Everolimus in advanced solid tumors: when to start, early or late?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
Rapamycin impairs beta-cell proliferation in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4852795
retrieved
28 November 2018
Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27048303
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/CSHPERSPECT.A025924
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
5013868
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
OpenCitations bibliographic resource ID
5013868
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
5013868
PMC publication ID
4852795
1 reference
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
PubMed publication ID
27048303
1 reference
stated in
Europe PubMed Central
PMC publication ID
4852795
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
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