(Q26781613)

8

0 references

Eugene Muratov

5

0 references

Rajarshi Guha

2

object named as

Rajarshi Guha

0 references

Richard Lewis

1 reference

ORCID Public Data File 2021

author name string

Krishna C Bulusu

1

0 references

Rajarshi Guha

2

0 references

Daniel J Mason

3

0 references

Richard P I Lewis

4

0 references

Yasaman Kalantar Motamedi

6

0 references

Murat Cokol

WOMBAT: World of Molecular Bioactivity

7

0 references

language of work or name

English

0 references

publication date

February 2016

0 references

published in

Drug Discovery Today

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volume

21

0 references

issue

2

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page(s)

225-38

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Arrhenius thermodynamics and birth defects: chemical teratogen synergy. Untested, testable, and projected relevance

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Molecular-targeted agents combination therapy for cancer: developments and potentials

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Existing and Developing Approaches for QSAR Analysis of Mixtures.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

QSPR Approach to Predict Nonadditive Properties of Mixtures. Application to Bubble Point Temperatures of Binary Mixtures of Liquids

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Effective elimination of cancer stem cells by a novel drug combination strategy

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Systems approaches and algorithms for discovery of combinatorial therapies

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Hierarchical QSAR technology based on the Simplex representation of molecular structure

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Review and management of side effects associated with antiplatelet therapy for prevention of recurrent cerebrovascular events

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Multi-target therapeutics: when the whole is greater than the sum of the parts

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Using transcriptomics to guide lead optimization in drug discovery projects: Lessons learned from the QSTAR project.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

A lethal combination for cancer cells: synthetic lethality screenings for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Topical methadone and meperidine analgesic synergy in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Combination therapy in hypertension

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Monotherapy versus combination therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Computational analysis of image-based drug profiling predicts synergistic drug combinations: applications in triple-negative breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Combination approaches to combat multidrug-resistant bacteria

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Informatics confronts drug-drug interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. FIN-RACo trial group

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Carbamazepine toxicity during combination therapy with levetiracetam: a pharmacodynamic interaction

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Abiraterone acetate plus prednisone versus prednisone alone in chemotherapy-naive men with metastatic castration-resistant prostate cancer: patient-reported outcome results of a randomised phase 3 trial.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Cell-based drug combination screening with a microfluidic droplet array system

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Network-based analysis and characterization of adverse drug-drug interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Target-independent prediction of drug synergies using only drug lipophilicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Rational approaches to improving selectivity in drug design

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Multitarget drug discovery for tuberculosis and other infectious diseases

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Quantitative prediction of antitarget interaction profiles for chemical compounds

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Systems toxicology: from basic research to risk assessment

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Chemogenomic profiling predicts antifungal synergies.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

A side effect resource to capture phenotypic effects of drugs

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Systematic exploration of synergistic drug pairs

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Chemical combination effects predict connectivity in biological systems

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Networks from drug-drug surfaces

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

All for one, one for all: new combinatorial RNAi therapies combat hepatitis C virus evolution

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Clonal evolution in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Synergistic drug combinations tend to improve therapeutically relevant selectivity

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

A community effort to assess and improve drug sensitivity prediction algorithms.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Combination chemical genetics

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Integrating high-content screening and ligand-target prediction to identify mechanism of action

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Drug discovery: engineering drug combinations

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

1 reference

7 January 2021

Functional classification of drugs by properties of their pairwise interactions.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Data integration: challenges for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Multicomponent therapeutics for networked systems

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Mechanisms of drug combinations: interaction and network perspectives

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Predicting cooperative drug effects through the quantitative cellular profiling of response to individual drugs

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Intestinal drug transporter expression and the impact of grapefruit juice in humans

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Combinatorial RNAi: a winning strategy for the race against evolving targets?

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Grapefruit juice-drug interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Combinatorial RNAi for quantitative protein network analysis

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Systematic discovery of multicomponent therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

A model-based approach for assessing in vivo combination therapy interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Two-Stage Model-Free Tests of Synergy in Drug Combinations

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

DCDB: drug combination database

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Discovering drug-drug interactions: a text-mining and reasoning approach based on properties of drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

DrugComboRanker: drug combination discovery based on target network analysis

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Augmentin (amoxicillin/clavulanate) in the treatment of community-acquired respiratory tract infection: a review of the continuing development of an innovative antimicrobial agent

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Pharmacokinetics and pharmacodynamics of drug interactions involving rifampicin, rifabutin and antimalarial drugs

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Update of TTD: Therapeutic Target Database

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

ChEMBL: a large-scale bioactivity database for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

NCBI GEO: archive for functional genomics data sets--update

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

DrugBank 4.0: shedding new light on drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

STITCH 4: integration of protein-chemical interactions with user data

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

The ToxCast program for prioritizing toxicity testing of environmental chemicals

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

An Integrated Approach to Anti-Cancer Drug Sensitivity Prediction

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Combine and conquer: advantages and disadvantages of fixed-dose combination therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Biogeographical analysis of chemical co-occurrence data to identify priorities for mixtures research.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

THE TOXICITY OF POISONS APPLIED JOINTLY

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Systematic genetic analysis with ordered arrays of yeast deletion mutants

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Global mapping of the yeast genetic interaction network

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Data-driven prediction of drug effects and interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Evaluation of the novel combination of high-dose daptomycin plus trimethoprim-sulfamethoxazole against daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus using an in vitro pharmacokinetic/pharmacodynamic model of simulated endocar

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Combination therapy for treatment of infections with gram-negative bacteria

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Gene expression studies using microarrays: principles, problems, and prospects

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Understanding synergy

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Accelerating cancer therapy development: the importance of combination strategies and collaboration. Summary of an Institute of Medicine workshop.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Prediction of drug combination chemosensitivity in human bladder cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Systematic error detection in experimental high-throughput screening

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

SignaLink 2 - a signaling pathway resource with multi-layered regulatory networks

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Systems biology approaches for advancing the discovery of effective drug combinations

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Carbamazepine toxicity induced by lopinavir/ritonavir and nelfinavir.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Systematic prediction of pharmacodynamic drug-drug interactions through protein-protein-interaction network

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Computational analyses of synergism in small molecular network motifs

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Searching for synergies: matrix algebraic approaches for efficient pair screening

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

ASDCD: antifungal synergistic drug combination database

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Visualization of network target crosstalk optimizes drug synergism in myocardial ischemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Combination antifungals: an update

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Interactions between herbal medicines and prescribed drugs: an updated systematic review

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Drug interactions with herbal medicines

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Quantitative phenotypic and pathway profiling guides rational drug combination strategies

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Herbo-mineral ayurvedic treatment in a high risk acute promyelocytic leukemia patient with second relapse: 12 years follow up.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Artemisinin-based combination treatment of falciparum malaria.

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021

Utilization of translational bioinformatics to identify novel biomarkers of bortezomib resistance in multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FJ.DRUDIS.2015.09.003

7 January 2021